Conserved Bacterial RNase YbeY Plays Key Roles in 70S Ribosome Quality Control and 16S rRNA Maturation

Quality control of ribosomes is critical for cellular function since protein mistranslation leads to severe physiological consequences. We report evidence of a previously unrecognized ribosome quality control system in bacteria that operates at the level of 70S to remove defective ribosomes. YbeY, a...

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Bibliographic Details
Published in:	Molecular cell Vol. 49; no. 3; pp. 427 - 438
Main Authors:	Jacob, Asha Ivy, Köhrer, Caroline, Davies, Bryan William, RajBhandary, Uttam Lal, Walker, Graham Charles
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 07-02-2013
Subjects:	Arginine - metabolism Bacteria Base Sequence Conserved Sequence Drugs Escherichia coli - drug effects Escherichia coli - enzymology Escherichia coli Proteins - chemistry Escherichia coli Proteins - metabolism Exoribonucleases - metabolism Histidine - metabolism Hot Temperature Metalloproteins - chemistry Metalloproteins - metabolism Metals - pharmacology Models, Biological Molecular Sequence Data Mutation - genetics Protein Biosynthesis - drug effects Ribosome Subunits, Small, Bacterial - metabolism Ribosomes - drug effects Ribosomes - metabolism RNA Processing, Post-Transcriptional - drug effects RNA, Ribosomal, 16S - genetics RNA, Ribosomal, 16S - metabolism Stress, Physiological - drug effects Substrate Specificity - drug effects
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