Spa-RQ: an Image Analysis Tool to Visualise and Quantify Spatial Phenotypes Applied to Non-Small Cell Lung Cancer

To facilitate analysis of spatial tissue phenotypes, we created an open-source tool package named ‘Spa-RQ’ for ‘Spatial tissue analysis: image Registration & Quantification’. Spa-RQ contains software for image registration (Spa-R) and quantitative analysis of DAB staining overlap (Spa-Q). It pro...

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Bibliographic Details
Published in:	Scientific reports Vol. 9; no. 1; pp. 17613 - 11
Main Authors:	Bao, Jie, Walliander, Margarita, Kovács, Ferenc, Nagaraj, Ashwini S., Hemmes, Annabrita, Sarhadi, Virinder Kaur, Knuutila, Sakari, Lundin, Johan, Horvath, Peter, Verschuren, Emmy W.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 26-11-2019 Nature Publishing Group
Subjects:	1-Phosphatidylinositol 3-kinase 13/51 14/105 3,3'-Diaminobenzidine 631/67/1612/1350 631/67/2329 64/110 96/1 96/63 AKT protein Biomarkers, Tumor Carcinoma, Non-Small-Cell Lung - chemistry Carcinoma, Non-Small-Cell Lung - pathology Genes, ras Hematoxylin Histopathology Humanities and Social Sciences Humans Image processing Image Processing, Computer-Assisted - methods Immunoenzyme Techniques Lung cancer Lung Neoplasms - chemistry Lung Neoplasms - pathology MAP kinase MAP Kinase Signaling System Medicin och hälsovetenskap Mitogen-Activated Protein Kinase Kinases - analysis multidisciplinary Neoplasm Proteins - analysis Non-small cell lung carcinoma p53 Protein Phenotype Phenotypes Phenotyping Phosphoproteins - analysis Proof of Concept Study Proto-Oncogene Proteins c-akt - analysis Science Science (multidisciplinary) Sectioning Signal Transduction Small cell lung carcinoma Software Spatial analysis Staining and Labeling - methods Tissue analysis TOR protein TOR Serine-Threonine Kinases - analysis Tumors
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