Tertiary Lymphoid Structures in Cancers: Prognostic Value, Regulation, and Manipulation for Therapeutic Intervention

Tertiary Lymphoid Structures in Cancers: Prognostic Value, Regulation, and Manipulation for Therapeutic Intervention

Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates that reflect lymphoid neogenesis occurring in tissues at sites of inflammation. They are detected in tumors where they orchestrate local and systemic anti-tumor responses. A correlation has been found between high densities of TLS an...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in immunology Vol. 7; p. 407
Main Authors: Sautès-Fridman, Catherine, Lawand, Myriam, Giraldo, Nicolas A, Kaplon, Hélène, Germain, Claire, Fridman, Wolf Herman, Dieu-Nosjean, Marie-Caroline
Format: Journal Article
Language:English
Published: Switzerland Frontiers 03-10-2016
Frontiers Media S.A
Subjects:
adaptive immune response
Cancer
chemokine
Immunology
Life Sciences
tertiary lymphoid structure
Tumor Microenvironment
tertiary lymphoid structure
chemokine
cancer
adaptive immune response
tumor microenvironment
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates that reflect lymphoid neogenesis occurring in tissues at sites of inflammation. They are detected in tumors where they orchestrate local and systemic anti-tumor responses. A correlation has been found between high densities of TLS and prolonged patient's survival in more than 10 different types of cancer. TLS can be regulated by the same set of chemokines and cytokines that orchestrate lymphoid organogenesis and by regulatory T cells. Thus, TLS offer a series of putative new targets that could be used to develop therapies aiming to increase the anti-tumor immune response.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Edited by: Andreas Habenicht, Ludwig Maximilian University of Munich, Germany
Specialty section: This article was submitted to Inflammation, a section of the journal Frontiers in Immunology
Reviewed by: Jo A. Van Ginderachter, Vrije Universiteit Brussel, Belgium; Yong-Gil Kim, University of Ulsan College of Medicine, South Korea
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2016.00407