Conjugation of Triterpenic Acids of Ursane and Oleanane Types with Mitochondria-Targeting Cation F16 Synergistically Enhanced Their Cytotoxicity against Tumor Cells

The present work shows the cytotoxic effects of novel conjugates of ursolic, oleanolic, maslinic, and corosolic acids with the penetrating cation F16 on cancer cells (lung adenocarcinoma A549 and H1299, breast cancer cell lines MCF-7 and BT474) and non-tumor human fibroblasts. It has been establishe...

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Bibliographic Details
Published in:	Membranes (Basel) Vol. 13; no. 6; p. 563
Main Authors:	Dubinin, Mikhail V, Nedopekina, Darya A, Ilzorkina, Anna I, Semenova, Alena A, Sharapov, Vyacheslav A, Davletshin, Eldar V, Mikina, Natalia V, Belsky, Yuri P, Spivak, Anna Yu, Akatov, Vladimir S, Belosludtseva, Natalia V, Liu, Jiankang, Belosludtsev, Konstantin N
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 30-05-2023 MDPI
Subjects:	Acids Adenocarcinoma Apoptosis Breast cancer Cancer Cations Cell cycle Chromatography Comparative analysis Conjugates Conjugation Cytotoxicity F16 Fibroblasts Liver diseases Lung cancer Membrane potential mitocans Mitochondria Molecular structure Organelles Oxidative phosphorylation Phosphorylation Toxicity triterpenic acids Tumor cell lines Tumor cells Tumors Massachusetts Russia Germany mitocans mitochondria ROS F16 cancer cytotoxicity oxidative phosphorylation triterpenic acids
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