Regeneration of ovine articular cartilage defects by cell-free polymer-based implants
Abstract The aim of our study was the evaluation of a cell-free cartilage implant that allows the recruitment of mesenchymal stem and progenitor cells by chemo-attractants and subsequent guidance of the progenitors to form cartilage repair tissue after microfracture. Chemotactic activity of human se...
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| Published in: | Biomaterials Vol. 28; no. 36; pp. 5570 - 5580 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
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01-12-2007
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| Abstract | Abstract The aim of our study was the evaluation of a cell-free cartilage implant that allows the recruitment of mesenchymal stem and progenitor cells by chemo-attractants and subsequent guidance of the progenitors to form cartilage repair tissue after microfracture. Chemotactic activity of human serum on human mesenchymal progenitors was tested in 96-well chemotaxis assays and chondrogenic differentiation was assessed by gene expression profiling after stimulating progenitors with hyaluronan in high-density cultures. Autologous serum and hyaluronan were combined with polyglycolic acid (PGA) scaffolds and were implanted into full-thickness articular cartilage defects of the sheep pre-treated with microfracture. Defects treated with microfracture served as controls. Human serum was a potent chemo-attractant and efficiently recruited mesenchymal progenitors. Chondrogenic differentiation of progenitors upon stimulation with hyaluronan was shown by the induction of typical chondrogenic marker genes like type II collagen and aggrecan. Three months after implantation of the cell-free implant, histological analysis documented the formation of a cartilaginous repair tissue. Controls treated with microfracture showed no formation of repair tissue. The cell-free cartilage implant consisting of autologous serum, hyaluronan and PGA utilizes the migration and differentiation potential of mesenchymal progenitors for cartilage regeneration and is well suited for the treatment of cartilage defects after microfracture. |
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| AbstractList | The aim of our study was the evaluation of a cell-free cartilage implant that allows the recruitment of mesenchymal stem and progenitor cells by chemo-attractants and subsequent guidance of the progenitors to form cartilage repair tissue after microfracture. Chemotactic activity of human serum on human mesenchymal progenitors was tested in 96-well chemotaxis assays and chondrogenic differentiation was assessed by gene expression profiling after stimulating progenitors with hyaluronan in high-density cultures. Autologous serum and hyaluronan were combined with polyglycolic acid (PGA) scaffolds and were implanted into full-thickness articular cartilage defects of the sheep pre-treated with microfracture. Defects treated with microfracture served as controls. Human serum was a potent chemo-attractant and efficiently recruited mesenchymal progenitors. Chondrogenic differentiation of progenitors upon stimulation with hyaluronan was shown by the induction of typical chondrogenic marker genes like type II collagen and aggrecan. Three months after implantation of the cell-free implant, histological analysis documented the formation of a cartilaginous repair tissue. Controls treated with microfracture showed no formation of repair tissue. The cell-free cartilage implant consisting of autologous serum, hyaluronan and PGA utilizes the migration and differentiation potential of mesenchymal progenitors for cartilage regeneration and is well suited for the treatment of cartilage defects after microfracture. Abstract The aim of our study was the evaluation of a cell-free cartilage implant that allows the recruitment of mesenchymal stem and progenitor cells by chemo-attractants and subsequent guidance of the progenitors to form cartilage repair tissue after microfracture. Chemotactic activity of human serum on human mesenchymal progenitors was tested in 96-well chemotaxis assays and chondrogenic differentiation was assessed by gene expression profiling after stimulating progenitors with hyaluronan in high-density cultures. Autologous serum and hyaluronan were combined with polyglycolic acid (PGA) scaffolds and were implanted into full-thickness articular cartilage defects of the sheep pre-treated with microfracture. Defects treated with microfracture served as controls. Human serum was a potent chemo-attractant and efficiently recruited mesenchymal progenitors. Chondrogenic differentiation of progenitors upon stimulation with hyaluronan was shown by the induction of typical chondrogenic marker genes like type II collagen and aggrecan. Three months after implantation of the cell-free implant, histological analysis documented the formation of a cartilaginous repair tissue. Controls treated with microfracture showed no formation of repair tissue. The cell-free cartilage implant consisting of autologous serum, hyaluronan and PGA utilizes the migration and differentiation potential of mesenchymal progenitors for cartilage regeneration and is well suited for the treatment of cartilage defects after microfracture. |
| Author | Endres, Michaela Neumann, Katja Haberstroh, Kathrin Sittinger, Michael Kaps, Christian Erggelet, Christoph |
| Author_xml | – sequence: 1 fullname: Erggelet, Christoph – sequence: 2 fullname: Neumann, Katja – sequence: 3 fullname: Endres, Michaela – sequence: 4 fullname: Haberstroh, Kathrin – sequence: 5 fullname: Sittinger, Michael – sequence: 6 fullname: Kaps, Christian |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17897710$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1097/00003086-200110001-00033 10.1186/ar623 10.2106/00004623-200403000-00001 10.1002/jcb.21172 10.1182/blood-2004-09-3507 10.1097/00003086-200005000-00020 10.1016/j.tice.2004.07.003 10.1053/jars.2002.32839 10.1016/8756-3282(92)90364-3 10.1016/j.biomaterials.2006.01.008 10.1007/s00018-005-5527-z 10.1053/jars.2003.50112 10.1002/jor.1100180516 10.1089/ten.2006.12.1787 10.2519/jospt.2006.2444 10.1002/jbm.b.30765 10.1002/jbm.820290915 10.1007/s00402-007-0348-1 10.1016/j.joca.2005.04.001 10.3928/0147-7447-20030901-28 10.2106/00004623-199304000-00009 10.1016/j.copbio.2004.08.010 10.1002/jor.20394 10.1053/jars.2003.50025 10.1097/00003086-200110001-00028 10.1007/s00441-004-1075-3 10.1016/j.joca.2005.11.007 10.1097/00003086-200302000-00031 10.1002/jcb.21319 10.1016/j.knee.2006.02.012 10.1016/S0749-8063(97)90124-9 10.1006/excr.1997.3858 10.1080/14653240600845070 10.1016/j.biomaterials.2006.01.041 10.1126/science.284.5411.143 10.1186/ar2180 10.1007/s001320050318 10.1097/00003086-200507000-00036 10.1002/1529-0131(199905)42:5<1033::AID-ANR24>3.0.CO;2-# 10.1016/j.arthro.2006.06.020 10.1002/jcb.10309 10.1016/j.biocel.2003.11.001 10.1089/107632702760240616 10.1002/jcp.10025 10.1097/01.blo.0000131638.81519.de 10.1007/s00142-005-0316-0 10.1016/j.biomaterials.2004.09.034 |
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| Keywords | Cartilage regeneration Microfracture Cell-free implant Chemotaxis Stem cells |
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| References | Kreuz, Erggelet, Steinwachs, Krause, Lahm, Niemeyer (bib12) 2006; 22 Roosendaal, TeKoppele, Vianen, van den Berg, Lafeber, Bijlsma (bib50) 1999; 42 Pittenger, Mackay, Beck, Jaiswal, Douglas, Mosca (bib6) 1999; 284 Sekiya, Larson, Vuoristo, Reger, Prockop (bib37) 2005; 320 Neumann K, Endres M, Ringe J, Flath B, Manz R, Haupl T, et al. BMP7 promotes adipogenic but not osteo-/chondrogenic differentiation of adult human bone marrow-derived stem cells in high-density micro-mass culture. J Cell Biochem 2007; Epub May 11. Minas (bib15) 2003; 26 Hollander, Dickinson, Sims, Brun, Cortivo, Kon (bib17) 2006; 12 Buckwalter, Brown (bib31) 2004; 423 Fiedler, Roderer, Gunther, Brenner (bib34) 2002; 87 Steadman, Rodkey, Rodrigo (bib5) 2001; 391 Gill, Asnis, Berkson (bib9) 2006; 36 Gotterbarm, Richter, Jung, Berardi Vilei, Mainil-Varlet, Yamashita (bib46) 2006; 27 Moreland (bib39) 2003; 5 Browne, Anderson, Arciero, Mandelbaum, Moseley, Micheli (bib14) 2005; 436 Knecht, Erggelet, Endres, Sittinger, Kaps, Stussi (bib48) 2007; 83 Barry, Murphy (bib36) 2004; 36 Erggelet, Sittinger, Lahm (bib29) 2003; 19 Ossendorf, Kaps, Kreuz, Burmester, Sittinger, Erggelet (bib19) 2007; 9 Knutsen, Engebretsen, Ludvigsen, Drogset, Grontvedt, Solheim (bib11) 2004; 86-A Dorotka, Windberger, Macfelda, Bindreiter, Toma, Nehrer (bib44) 2005; 26 Behrens, Bitter, Kurz, Russlies (bib18) 2006; 13 Dorotka, Bindreiter, Macfelda, Windberger, Nehrer (bib43) 2005; 13 Steadman, Briggs, Rodrigo, Kocher, Gill, Rodkey (bib10) 2003; 19 Ringe, Strassburg, Neumann, Endres, Notter, Burmester (bib33) 2007; 101 Haynesworth, Goshima, Goldberg, Caplan (bib25) 1992; 13 Chu, Coutts, Yoshioka, Harwood, Monosov, Amiel (bib20) 1995; 29 Peterson, Minas, Brittberg, Nilsson, Sjogren-Jansson, Lindahl (bib16) 2000; 374 Buckwalter, Martin, Olmstead, Athanasiou, Rosenwasser, Mow (bib30) 2003; 23 Kayakabe, Tsutsumi, Watanabe, Kato, Takagishi (bib41) 2006; 8 Behrens (bib45) 2005; 18 Johnstone, Hering, Caplan, Goldberg, Yoo (bib28) 1998; 238 Steadman, Rodkey, Briggs, Rodrigo (bib8) 1999; 28 Johnson (bib4) 2001; 391 Hegewald, Ringe, Bartel, Kruger, Notter, Barnewitz (bib40) 2004; 36 Pridie (bib3) 1959; 41 Hjelle, Solheim, Strand, Muri, Brittberg (bib2) 2002; 18 Barnewitz, Endres, Kruger, Becker, Zimmermann, Wilke (bib23) 2006; 27 Petersen W, Zelle S, Zantop T. Arthroscopic implantation of a three dimensional scaffold for autologous chondrocyte transplantation. Arch Orthop Trauma Surg 2007; Epub May 16. Liu, Chen, Liu, Cui, Shang, Xia (bib21) 2002; 8 Endres M, Neumann K, Haupl T, Erggelet C, Ringe J, Sittinger M, et al. Synovial fluid recruits human mesenchymal progenitors from subchondral spongious bone marrow. J Orthop Res 2007;Epub June 4. Kramer, Bohrnsen, Lindner, Behrens, Schlenke, Rohwedel (bib35) 2006; 63 Hooiveld, Roosendaal, Vianen, van den Berg, Bijlsma, Lafeber (bib51) 2003; 30 Curl, Krome, Gordon, Rushing, Smith, Poehling (bib1) 1997; 13 Sordi, Malosio, Marchesi, Mercalli, Melzi, Giordano (bib32) 2005; 106 Frisbie, Oxford, Southwood, Trotter, Rodkey, Steadman (bib13) 2003; 407 Drobnic, Radosavljevic, Ravnik, Pavlovcic, Hribernik (bib47) 2006; 14 Kaps, Frauenschuh, Endres, Ringe, Haisch, Lauber (bib22) 2006; 27 Sittinger, Hutmacher, Risbud (bib24) 2004; 15 Majumdar, Wang, Morris (bib38) 2001; 189 Shapiro, Koide, Glimcher (bib7) 1993; 75 Breinan, Martin, Hsu, Spector (bib42) 2000; 18 Barnewitz (10.1016/j.biomaterials.2007.09.005_bib23) 2006; 27 Johnson (10.1016/j.biomaterials.2007.09.005_bib4) 2001; 391 Hooiveld (10.1016/j.biomaterials.2007.09.005_bib51) 2003; 30 Gotterbarm (10.1016/j.biomaterials.2007.09.005_bib46) 2006; 27 Roosendaal (10.1016/j.biomaterials.2007.09.005_bib50) 1999; 42 Chu (10.1016/j.biomaterials.2007.09.005_bib20) 1995; 29 Haynesworth (10.1016/j.biomaterials.2007.09.005_bib25) 1992; 13 Sordi (10.1016/j.biomaterials.2007.09.005_bib32) 2005; 106 Shapiro (10.1016/j.biomaterials.2007.09.005_bib7) 1993; 75 Fiedler (10.1016/j.biomaterials.2007.09.005_bib34) 2002; 87 Sekiya (10.1016/j.biomaterials.2007.09.005_bib37) 2005; 320 Pittenger (10.1016/j.biomaterials.2007.09.005_bib6) 1999; 284 Hollander (10.1016/j.biomaterials.2007.09.005_bib17) 2006; 12 Kayakabe (10.1016/j.biomaterials.2007.09.005_bib41) 2006; 8 Browne (10.1016/j.biomaterials.2007.09.005_bib14) 2005; 436 10.1016/j.biomaterials.2007.09.005_bib49 Buckwalter (10.1016/j.biomaterials.2007.09.005_bib30) 2003; 23 Dorotka (10.1016/j.biomaterials.2007.09.005_bib43) 2005; 13 Steadman (10.1016/j.biomaterials.2007.09.005_bib10) 2003; 19 Steadman (10.1016/j.biomaterials.2007.09.005_bib5) 2001; 391 Kaps (10.1016/j.biomaterials.2007.09.005_bib22) 2006; 27 Hegewald (10.1016/j.biomaterials.2007.09.005_bib40) 2004; 36 Johnstone (10.1016/j.biomaterials.2007.09.005_bib28) 1998; 238 Erggelet (10.1016/j.biomaterials.2007.09.005_bib29) 2003; 19 Buckwalter (10.1016/j.biomaterials.2007.09.005_bib31) 2004; 423 Frisbie (10.1016/j.biomaterials.2007.09.005_bib13) 2003; 407 Kreuz (10.1016/j.biomaterials.2007.09.005_bib12) 2006; 22 Ringe (10.1016/j.biomaterials.2007.09.005_bib33) 2007; 101 Breinan (10.1016/j.biomaterials.2007.09.005_bib42) 2000; 18 Pridie (10.1016/j.biomaterials.2007.09.005_bib3) 1959; 41 Kramer (10.1016/j.biomaterials.2007.09.005_bib35) 2006; 63 Behrens (10.1016/j.biomaterials.2007.09.005_bib45) 2005; 18 Drobnic (10.1016/j.biomaterials.2007.09.005_bib47) 2006; 14 Gill (10.1016/j.biomaterials.2007.09.005_bib9) 2006; 36 Minas (10.1016/j.biomaterials.2007.09.005_bib15) 2003; 26 Sittinger (10.1016/j.biomaterials.2007.09.005_bib24) 2004; 15 Peterson (10.1016/j.biomaterials.2007.09.005_bib16) 2000; 374 Liu (10.1016/j.biomaterials.2007.09.005_bib21) 2002; 8 Moreland (10.1016/j.biomaterials.2007.09.005_bib39) 2003; 5 Curl (10.1016/j.biomaterials.2007.09.005_bib1) 1997; 13 Majumdar (10.1016/j.biomaterials.2007.09.005_bib38) 2001; 189 10.1016/j.biomaterials.2007.09.005_bib27 Knecht (10.1016/j.biomaterials.2007.09.005_bib48) 2007; 83 Steadman (10.1016/j.biomaterials.2007.09.005_bib8) 1999; 28 Dorotka (10.1016/j.biomaterials.2007.09.005_bib44) 2005; 26 Hjelle (10.1016/j.biomaterials.2007.09.005_bib2) 2002; 18 Ossendorf (10.1016/j.biomaterials.2007.09.005_bib19) 2007; 9 Behrens (10.1016/j.biomaterials.2007.09.005_bib18) 2006; 13 Knutsen (10.1016/j.biomaterials.2007.09.005_bib11) 2004; 86-A Barry (10.1016/j.biomaterials.2007.09.005_bib36) 2004; 36 10.1016/j.biomaterials.2007.09.005_bib26 |
| References_xml | – volume: 101 start-page: 135 year: 2007 end-page: 146 ident: bib33 article-title: Towards in situ tissue repair: human mesenchymal stem cells express chemokine receptors CXCR1, CXCR2 and CCR2, and migrate upon stimulation with CXCL8 but not CCL2 publication-title: J Cell Biochem contributor: fullname: Burmester – volume: 19 start-page: 477 year: 2003 end-page: 484 ident: bib10 article-title: Outcomes of microfracture for traumatic chondral defects of the knee: average 11-year follow-up publication-title: Arthroscopy contributor: fullname: Rodkey – volume: 12 start-page: 1787 year: 2006 end-page: 1798 ident: bib17 article-title: Maturation of tissue engineered cartilage implanted in injured and osteoarthritic human knees publication-title: Tissue Eng contributor: fullname: Kon – volume: 30 start-page: 339 year: 2003 end-page: 344 ident: bib51 article-title: Blood-induced joint damage: longterm effects in vitro and in vivo publication-title: J Rheumatol contributor: fullname: Lafeber – volume: 423 start-page: 7 year: 2004 end-page: 16 ident: bib31 article-title: Joint injury, repair, and remodeling: roles in post-traumatic osteoarthritis publication-title: Clin Orthop Relat Res contributor: fullname: Brown – volume: 36 start-page: 568 year: 2004 end-page: 584 ident: bib36 article-title: Mesenchymal stem cells: clinical applications and biological characterization publication-title: Int J Biochem Cell Biol contributor: fullname: Murphy – volume: 28 start-page: 26 year: 1999 end-page: 32 ident: bib8 article-title: The microfracture technic in the management of complete cartilage defects in the knee joint publication-title: Orthopade contributor: fullname: Rodrigo – volume: 36 start-page: 728 year: 2006 end-page: 738 ident: bib9 article-title: The treatment of articular cartilage defects using the microfracture technique publication-title: J Orthop Sports Phys Ther contributor: fullname: Berkson – volume: 8 start-page: 709 year: 2002 end-page: 721 ident: bib21 article-title: Repairing large porcine full-thickness defects of articular cartilage using autologous chondrocyte-engineered cartilage publication-title: Tissue Eng contributor: fullname: Xia – volume: 63 start-page: 616 year: 2006 end-page: 626 ident: bib35 article-title: In vivo matrix-guided human mesenchymal stem cells publication-title: Cell Mol Life Sci contributor: fullname: Rohwedel – volume: 36 start-page: 431 year: 2004 end-page: 438 ident: bib40 article-title: Hyaluronic acid and autologous synovial fluid induce chondrogenic differentiation of equine mesenchymal stem cells: a preliminary study publication-title: Tissue Cell contributor: fullname: Barnewitz – volume: 42 start-page: 1033 year: 1999 end-page: 1039 ident: bib50 article-title: Blood-induced joint damage: a canine in vivo study publication-title: Arthritis Rheum contributor: fullname: Bijlsma – volume: 29 start-page: 1147 year: 1995 end-page: 1154 ident: bib20 article-title: Articular cartilage repair using allogeneic perichondrocyte-seeded biodegradable porous polylactic acid (PLA): a tissue-engineering study publication-title: J Biomed Mater Res contributor: fullname: Amiel – volume: 8 start-page: 343 year: 2006 end-page: 353 ident: bib41 article-title: Transplantation of autologous rabbit BM-derived mesenchymal stromal cells embedded in hyaluronic acid gel sponge into osteochondral defects of the knee publication-title: Cytotherapy contributor: fullname: Takagishi – volume: 320 start-page: 269 year: 2005 end-page: 276 ident: bib37 article-title: Comparison of effect of BMP-2, -4, and -6 on in vitro cartilage formation of human adult stem cells from bone marrow stroma publication-title: Cell Tissue Res contributor: fullname: Prockop – volume: 18 start-page: 730 year: 2002 end-page: 734 ident: bib2 article-title: Articular cartilage defects in 1,000 knee arthroscopies publication-title: Arthroscopy contributor: fullname: Brittberg – volume: 5 start-page: 54 year: 2003 end-page: 67 ident: bib39 article-title: Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action publication-title: Arthritis Res Ther contributor: fullname: Moreland – volume: 391 start-page: S362 year: 2001 end-page: S369 ident: bib5 article-title: Microfracture: surgical technique and rehabilitation to treat chondral defects publication-title: Clin Orthop Relat Res contributor: fullname: Rodrigo – volume: 13 start-page: 81 year: 1992 end-page: 88 ident: bib25 article-title: Characterization of cells with osteogenic potential from human marrow publication-title: Bone contributor: fullname: Caplan – volume: 374 start-page: 212 year: 2000 end-page: 234 ident: bib16 article-title: Two- to 9-year outcome after autologous chondrocyte transplantation of the knee publication-title: Clin Orthop Relat Res contributor: fullname: Lindahl – volume: 86-A start-page: 455 year: 2004 end-page: 464 ident: bib11 article-title: Autologous chondrocyte implantation compared with microfracture in the knee. A randomized trial publication-title: J Bone Joint Surg Am contributor: fullname: Solheim – volume: 106 start-page: 419 year: 2005 end-page: 427 ident: bib32 article-title: Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets publication-title: Blood contributor: fullname: Giordano – volume: 18 start-page: 193 year: 2005 end-page: 197 ident: bib45 article-title: Matrix-coupled microfracture-a new concept for cartilage defect repair (in German) publication-title: Arthroskopie contributor: fullname: Behrens – volume: 15 start-page: 411 year: 2004 end-page: 418 ident: bib24 article-title: Current strategies for cell delivery in cartilage and bone regeneration publication-title: Curr Opin Biotechnol contributor: fullname: Risbud – volume: 23 start-page: 66 year: 2003 end-page: 74 ident: bib30 article-title: Osteochondral repair of primate knee femoral and patellar articular surfaces: implications for preventing post-traumatic osteoarthritis publication-title: Iowa Orthop J contributor: fullname: Mow – volume: 26 start-page: 945 year: 2003 end-page: 947 ident: bib15 article-title: Autologous chondrocyte implantation in the arthritic knee publication-title: Orthopedics contributor: fullname: Minas – volume: 27 start-page: 3387 year: 2006 end-page: 3395 ident: bib46 article-title: An in vivo study of a growth-factor enhanced, cell free, two-layered collagen–tricalcium phosphate in deep osteochondral defects publication-title: Biomaterials contributor: fullname: Yamashita – volume: 13 start-page: 655 year: 2005 end-page: 664 ident: bib43 article-title: Marrow stimulation and chondrocyte transplantation using a collagen matrix for cartilage repair publication-title: Osteoarthritis Cartil contributor: fullname: Nehrer – volume: 436 start-page: 237 year: 2005 end-page: 245 ident: bib14 article-title: Clinical outcome of autologous chondrocyte implantation at 5 years in US subjects publication-title: Clin Orthop Relat Res contributor: fullname: Micheli – volume: 83 start-page: 50 year: 2007 end-page: 57 ident: bib48 article-title: Mechanical testing of fixation techniques for scaffold-based tissue-engineered grafts publication-title: J Biomed Mater Res B Appl Biomater contributor: fullname: Stussi – volume: 189 start-page: 275 year: 2001 end-page: 284 ident: bib38 article-title: BMP-2 and BMP-9 promotes chondrogenic differentiation of human multipotential mesenchymal cells and overcomes the inhibitory effect of IL-1 publication-title: J Cell Physiol contributor: fullname: Morris – volume: 18 start-page: 781 year: 2000 end-page: 789 ident: bib42 article-title: Healing of canine articular cartilage defects treated with microfracture, a type-II collagen matrix, or cultured autologous chondrocytes publication-title: J Orthop Res contributor: fullname: Spector – volume: 27 start-page: 3617 year: 2006 end-page: 3630 ident: bib22 article-title: Gene expression profiling of human articular cartilage grafts generated by tissue engineering publication-title: Biomaterials contributor: fullname: Lauber – volume: 22 start-page: 1180 year: 2006 end-page: 1186 ident: bib12 article-title: Is microfracture of chondral defects in the knee associated with different results in patients aged 40 years or younger? publication-title: Arthroscopy contributor: fullname: Niemeyer – volume: 87 start-page: 305 year: 2002 end-page: 312 ident: bib34 article-title: BMP-2, BMP-4, and PDGF-bb stimulate chemotactic migration of primary human mesenchymal progenitor cells publication-title: J Cell Biochem contributor: fullname: Brenner – volume: 13 start-page: 456 year: 1997 end-page: 460 ident: bib1 article-title: Cartilage injuries: a review of 31,516 knee arthroscopies publication-title: Arthroscopy contributor: fullname: Poehling – volume: 238 start-page: 265 year: 1998 end-page: 272 ident: bib28 article-title: In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells publication-title: Exp Cell Res contributor: fullname: Yoo – volume: 407 start-page: 215 year: 2003 end-page: 227 ident: bib13 article-title: Early events in cartilage repair after subchondral bone microfracture publication-title: Clin Orthop Relat Res contributor: fullname: Steadman – volume: 13 start-page: 194 year: 2006 end-page: 202 ident: bib18 article-title: Matrix-associated autologous chondrocyte transplantation/implantation (MACT/MACI)—5-year follow-up publication-title: Knee contributor: fullname: Russlies – volume: 9 start-page: R41 year: 2007 ident: bib19 article-title: Treatment of posttraumatic and focal osteoarthritic cartilage defects of the knee with autologous polymer-based three-dimensional chondrocyte grafts: 2-year clinical results publication-title: Arthritis Res Ther contributor: fullname: Erggelet – volume: 19 start-page: 108 year: 2003 end-page: 110 ident: bib29 article-title: The arthroscopic implantation of autologous chondrocytes for the treatment of full-thickness cartilage defects of the knee joint publication-title: Arthroscopy contributor: fullname: Lahm – volume: 14 start-page: 337 year: 2006 end-page: 344 ident: bib47 article-title: Comparison of four techniques for the fixation of a collagen scaffold in the human cadaveric knee publication-title: Osteoarthritis Cartil contributor: fullname: Hribernik – volume: 391 start-page: S306 year: 2001 end-page: S317 ident: bib4 article-title: Arthroscopic abrasion arthroplasty: a review publication-title: Clin Orthop Relat Res contributor: fullname: Johnson – volume: 41 start-page: 418 year: 1959 end-page: 419 ident: bib3 article-title: A method of resurfacing osteoarthritic knee joints publication-title: J Bone Joint Surg [Br] contributor: fullname: Pridie – volume: 284 start-page: 143 year: 1999 end-page: 147 ident: bib6 article-title: Multilineage potential of adult human mesenchymal stem cells publication-title: Science contributor: fullname: Mosca – volume: 27 start-page: 2882 year: 2006 end-page: 2889 ident: bib23 article-title: Treatment of articular cartilage defects in horses with polymer-based cartilage tissue engineering grafts publication-title: Biomaterials contributor: fullname: Wilke – volume: 26 start-page: 3617 year: 2005 end-page: 3629 ident: bib44 article-title: Repair of articular cartilage defects treated by microfracture and a three-dimensional collagen matrix publication-title: Biomaterials contributor: fullname: Nehrer – volume: 75 start-page: 532 year: 1993 end-page: 553 ident: bib7 article-title: Cell origin and differentiation in the repair of full-thickness defects of articular cartilage publication-title: J Bone Joint Surg Am contributor: fullname: Glimcher – volume: 391 start-page: S362 year: 2001 ident: 10.1016/j.biomaterials.2007.09.005_bib5 article-title: Microfracture: surgical technique and rehabilitation to treat chondral defects publication-title: Clin Orthop Relat Res doi: 10.1097/00003086-200110001-00033 contributor: fullname: Steadman – volume: 5 start-page: 54 year: 2003 ident: 10.1016/j.biomaterials.2007.09.005_bib39 article-title: Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action publication-title: Arthritis Res Ther doi: 10.1186/ar623 contributor: fullname: Moreland – volume: 86-A start-page: 455 year: 2004 ident: 10.1016/j.biomaterials.2007.09.005_bib11 article-title: Autologous chondrocyte implantation compared with microfracture in the knee. A randomized trial publication-title: J Bone Joint Surg Am doi: 10.2106/00004623-200403000-00001 contributor: fullname: Knutsen – volume: 101 start-page: 135 year: 2007 ident: 10.1016/j.biomaterials.2007.09.005_bib33 article-title: Towards in situ tissue repair: human mesenchymal stem cells express chemokine receptors CXCR1, CXCR2 and CCR2, and migrate upon stimulation with CXCL8 but not CCL2 publication-title: J Cell Biochem doi: 10.1002/jcb.21172 contributor: fullname: Ringe – volume: 106 start-page: 419 year: 2005 ident: 10.1016/j.biomaterials.2007.09.005_bib32 article-title: Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets publication-title: Blood doi: 10.1182/blood-2004-09-3507 contributor: fullname: Sordi – volume: 374 start-page: 212 year: 2000 ident: 10.1016/j.biomaterials.2007.09.005_bib16 article-title: Two- to 9-year outcome after autologous chondrocyte transplantation of the knee publication-title: Clin Orthop Relat Res doi: 10.1097/00003086-200005000-00020 contributor: fullname: Peterson – volume: 36 start-page: 431 year: 2004 ident: 10.1016/j.biomaterials.2007.09.005_bib40 article-title: Hyaluronic acid and autologous synovial fluid induce chondrogenic differentiation of equine mesenchymal stem cells: a preliminary study publication-title: Tissue Cell doi: 10.1016/j.tice.2004.07.003 contributor: fullname: Hegewald – volume: 18 start-page: 730 year: 2002 ident: 10.1016/j.biomaterials.2007.09.005_bib2 article-title: Articular cartilage defects in 1,000 knee arthroscopies publication-title: Arthroscopy doi: 10.1053/jars.2002.32839 contributor: fullname: Hjelle – volume: 13 start-page: 81 year: 1992 ident: 10.1016/j.biomaterials.2007.09.005_bib25 article-title: Characterization of cells with osteogenic potential from human marrow publication-title: Bone doi: 10.1016/8756-3282(92)90364-3 contributor: fullname: Haynesworth – volume: 23 start-page: 66 year: 2003 ident: 10.1016/j.biomaterials.2007.09.005_bib30 article-title: Osteochondral repair of primate knee femoral and patellar articular surfaces: implications for preventing post-traumatic osteoarthritis publication-title: Iowa Orthop J contributor: fullname: Buckwalter – volume: 27 start-page: 2882 year: 2006 ident: 10.1016/j.biomaterials.2007.09.005_bib23 article-title: Treatment of articular cartilage defects in horses with polymer-based cartilage tissue engineering grafts publication-title: Biomaterials doi: 10.1016/j.biomaterials.2006.01.008 contributor: fullname: Barnewitz – volume: 63 start-page: 616 year: 2006 ident: 10.1016/j.biomaterials.2007.09.005_bib35 article-title: In vivo matrix-guided human mesenchymal stem cells publication-title: Cell Mol Life Sci doi: 10.1007/s00018-005-5527-z contributor: fullname: Kramer – volume: 19 start-page: 477 year: 2003 ident: 10.1016/j.biomaterials.2007.09.005_bib10 article-title: Outcomes of microfracture for traumatic chondral defects of the knee: average 11-year follow-up publication-title: Arthroscopy doi: 10.1053/jars.2003.50112 contributor: fullname: Steadman – volume: 18 start-page: 781 year: 2000 ident: 10.1016/j.biomaterials.2007.09.005_bib42 article-title: Healing of canine articular cartilage defects treated with microfracture, a type-II collagen matrix, or cultured autologous chondrocytes publication-title: J Orthop Res doi: 10.1002/jor.1100180516 contributor: fullname: Breinan – volume: 30 start-page: 339 year: 2003 ident: 10.1016/j.biomaterials.2007.09.005_bib51 article-title: Blood-induced joint damage: longterm effects in vitro and in vivo publication-title: J Rheumatol contributor: fullname: Hooiveld – volume: 12 start-page: 1787 year: 2006 ident: 10.1016/j.biomaterials.2007.09.005_bib17 article-title: Maturation of tissue engineered cartilage implanted in injured and osteoarthritic human knees publication-title: Tissue Eng doi: 10.1089/ten.2006.12.1787 contributor: fullname: Hollander – volume: 27 start-page: 3617 year: 2006 ident: 10.1016/j.biomaterials.2007.09.005_bib22 article-title: Gene expression profiling of human articular cartilage grafts generated by tissue engineering publication-title: Biomaterials contributor: fullname: Kaps – volume: 36 start-page: 728 year: 2006 ident: 10.1016/j.biomaterials.2007.09.005_bib9 article-title: The treatment of articular cartilage defects using the microfracture technique publication-title: J Orthop Sports Phys Ther doi: 10.2519/jospt.2006.2444 contributor: fullname: Gill – volume: 83 start-page: 50 year: 2007 ident: 10.1016/j.biomaterials.2007.09.005_bib48 article-title: Mechanical testing of fixation techniques for scaffold-based tissue-engineered grafts publication-title: J Biomed Mater Res B Appl Biomater doi: 10.1002/jbm.b.30765 contributor: fullname: Knecht – volume: 29 start-page: 1147 year: 1995 ident: 10.1016/j.biomaterials.2007.09.005_bib20 article-title: Articular cartilage repair using allogeneic perichondrocyte-seeded biodegradable porous polylactic acid (PLA): a tissue-engineering study publication-title: J Biomed Mater Res doi: 10.1002/jbm.820290915 contributor: fullname: Chu – ident: 10.1016/j.biomaterials.2007.09.005_bib49 doi: 10.1007/s00402-007-0348-1 – volume: 13 start-page: 655 year: 2005 ident: 10.1016/j.biomaterials.2007.09.005_bib43 article-title: Marrow stimulation and chondrocyte transplantation using a collagen matrix for cartilage repair publication-title: Osteoarthritis Cartil doi: 10.1016/j.joca.2005.04.001 contributor: fullname: Dorotka – volume: 26 start-page: 945 year: 2003 ident: 10.1016/j.biomaterials.2007.09.005_bib15 article-title: Autologous chondrocyte implantation in the arthritic knee publication-title: Orthopedics doi: 10.3928/0147-7447-20030901-28 contributor: fullname: Minas – volume: 75 start-page: 532 year: 1993 ident: 10.1016/j.biomaterials.2007.09.005_bib7 article-title: Cell origin and differentiation in the repair of full-thickness defects of articular cartilage publication-title: J Bone Joint Surg Am doi: 10.2106/00004623-199304000-00009 contributor: fullname: Shapiro – volume: 15 start-page: 411 year: 2004 ident: 10.1016/j.biomaterials.2007.09.005_bib24 article-title: Current strategies for cell delivery in cartilage and bone regeneration publication-title: Curr Opin Biotechnol doi: 10.1016/j.copbio.2004.08.010 contributor: fullname: Sittinger – ident: 10.1016/j.biomaterials.2007.09.005_bib27 doi: 10.1002/jor.20394 – volume: 19 start-page: 108 year: 2003 ident: 10.1016/j.biomaterials.2007.09.005_bib29 article-title: The arthroscopic implantation of autologous chondrocytes for the treatment of full-thickness cartilage defects of the knee joint publication-title: Arthroscopy doi: 10.1053/jars.2003.50025 contributor: fullname: Erggelet – volume: 391 start-page: S306 year: 2001 ident: 10.1016/j.biomaterials.2007.09.005_bib4 article-title: Arthroscopic abrasion arthroplasty: a review publication-title: Clin Orthop Relat Res doi: 10.1097/00003086-200110001-00028 contributor: fullname: Johnson – volume: 320 start-page: 269 year: 2005 ident: 10.1016/j.biomaterials.2007.09.005_bib37 article-title: Comparison of effect of BMP-2, -4, and -6 on in vitro cartilage formation of human adult stem cells from bone marrow stroma publication-title: Cell Tissue Res doi: 10.1007/s00441-004-1075-3 contributor: fullname: Sekiya – volume: 14 start-page: 337 year: 2006 ident: 10.1016/j.biomaterials.2007.09.005_bib47 article-title: Comparison of four techniques for the fixation of a collagen scaffold in the human cadaveric knee publication-title: Osteoarthritis Cartil doi: 10.1016/j.joca.2005.11.007 contributor: fullname: Drobnic – volume: 407 start-page: 215 year: 2003 ident: 10.1016/j.biomaterials.2007.09.005_bib13 article-title: Early events in cartilage repair after subchondral bone microfracture publication-title: Clin Orthop Relat Res doi: 10.1097/00003086-200302000-00031 contributor: fullname: Frisbie – ident: 10.1016/j.biomaterials.2007.09.005_bib26 doi: 10.1002/jcb.21319 – volume: 13 start-page: 194 year: 2006 ident: 10.1016/j.biomaterials.2007.09.005_bib18 article-title: Matrix-associated autologous chondrocyte transplantation/implantation (MACT/MACI)—5-year follow-up publication-title: Knee doi: 10.1016/j.knee.2006.02.012 contributor: fullname: Behrens – volume: 13 start-page: 456 year: 1997 ident: 10.1016/j.biomaterials.2007.09.005_bib1 article-title: Cartilage injuries: a review of 31,516 knee arthroscopies publication-title: Arthroscopy doi: 10.1016/S0749-8063(97)90124-9 contributor: fullname: Curl – volume: 238 start-page: 265 year: 1998 ident: 10.1016/j.biomaterials.2007.09.005_bib28 article-title: In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells publication-title: Exp Cell Res doi: 10.1006/excr.1997.3858 contributor: fullname: Johnstone – volume: 8 start-page: 343 year: 2006 ident: 10.1016/j.biomaterials.2007.09.005_bib41 article-title: Transplantation of autologous rabbit BM-derived mesenchymal stromal cells embedded in hyaluronic acid gel sponge into osteochondral defects of the knee publication-title: Cytotherapy doi: 10.1080/14653240600845070 contributor: fullname: Kayakabe – volume: 27 start-page: 3387 year: 2006 ident: 10.1016/j.biomaterials.2007.09.005_bib46 article-title: An in vivo study of a growth-factor enhanced, cell free, two-layered collagen–tricalcium phosphate in deep osteochondral defects publication-title: Biomaterials doi: 10.1016/j.biomaterials.2006.01.041 contributor: fullname: Gotterbarm – volume: 284 start-page: 143 year: 1999 ident: 10.1016/j.biomaterials.2007.09.005_bib6 article-title: Multilineage potential of adult human mesenchymal stem cells publication-title: Science doi: 10.1126/science.284.5411.143 contributor: fullname: Pittenger – volume: 9 start-page: R41 year: 2007 ident: 10.1016/j.biomaterials.2007.09.005_bib19 article-title: Treatment of posttraumatic and focal osteoarthritic cartilage defects of the knee with autologous polymer-based three-dimensional chondrocyte grafts: 2-year clinical results publication-title: Arthritis Res Ther doi: 10.1186/ar2180 contributor: fullname: Ossendorf – volume: 28 start-page: 26 year: 1999 ident: 10.1016/j.biomaterials.2007.09.005_bib8 article-title: The microfracture technic in the management of complete cartilage defects in the knee joint publication-title: Orthopade doi: 10.1007/s001320050318 contributor: fullname: Steadman – volume: 436 start-page: 237 year: 2005 ident: 10.1016/j.biomaterials.2007.09.005_bib14 article-title: Clinical outcome of autologous chondrocyte implantation at 5 years in US subjects publication-title: Clin Orthop Relat Res doi: 10.1097/00003086-200507000-00036 contributor: fullname: Browne – volume: 42 start-page: 1033 year: 1999 ident: 10.1016/j.biomaterials.2007.09.005_bib50 article-title: Blood-induced joint damage: a canine in vivo study publication-title: Arthritis Rheum doi: 10.1002/1529-0131(199905)42:5<1033::AID-ANR24>3.0.CO;2-# contributor: fullname: Roosendaal – volume: 22 start-page: 1180 year: 2006 ident: 10.1016/j.biomaterials.2007.09.005_bib12 article-title: Is microfracture of chondral defects in the knee associated with different results in patients aged 40 years or younger? publication-title: Arthroscopy doi: 10.1016/j.arthro.2006.06.020 contributor: fullname: Kreuz – volume: 87 start-page: 305 year: 2002 ident: 10.1016/j.biomaterials.2007.09.005_bib34 article-title: BMP-2, BMP-4, and PDGF-bb stimulate chemotactic migration of primary human mesenchymal progenitor cells publication-title: J Cell Biochem doi: 10.1002/jcb.10309 contributor: fullname: Fiedler – volume: 36 start-page: 568 year: 2004 ident: 10.1016/j.biomaterials.2007.09.005_bib36 article-title: Mesenchymal stem cells: clinical applications and biological characterization publication-title: Int J Biochem Cell Biol doi: 10.1016/j.biocel.2003.11.001 contributor: fullname: Barry – volume: 8 start-page: 709 year: 2002 ident: 10.1016/j.biomaterials.2007.09.005_bib21 article-title: Repairing large porcine full-thickness defects of articular cartilage using autologous chondrocyte-engineered cartilage publication-title: Tissue Eng doi: 10.1089/107632702760240616 contributor: fullname: Liu – volume: 189 start-page: 275 year: 2001 ident: 10.1016/j.biomaterials.2007.09.005_bib38 article-title: BMP-2 and BMP-9 promotes chondrogenic differentiation of human multipotential mesenchymal cells and overcomes the inhibitory effect of IL-1 publication-title: J Cell Physiol doi: 10.1002/jcp.10025 contributor: fullname: Majumdar – volume: 423 start-page: 7 year: 2004 ident: 10.1016/j.biomaterials.2007.09.005_bib31 article-title: Joint injury, repair, and remodeling: roles in post-traumatic osteoarthritis publication-title: Clin Orthop Relat Res doi: 10.1097/01.blo.0000131638.81519.de contributor: fullname: Buckwalter – volume: 41 start-page: 418 year: 1959 ident: 10.1016/j.biomaterials.2007.09.005_bib3 article-title: A method of resurfacing osteoarthritic knee joints publication-title: J Bone Joint Surg [Br] contributor: fullname: Pridie – volume: 18 start-page: 193 year: 2005 ident: 10.1016/j.biomaterials.2007.09.005_bib45 article-title: Matrix-coupled microfracture-a new concept for cartilage defect repair (in German) publication-title: Arthroskopie doi: 10.1007/s00142-005-0316-0 contributor: fullname: Behrens – volume: 26 start-page: 3617 year: 2005 ident: 10.1016/j.biomaterials.2007.09.005_bib44 article-title: Repair of articular cartilage defects treated by microfracture and a three-dimensional collagen matrix publication-title: Biomaterials doi: 10.1016/j.biomaterials.2004.09.034 contributor: fullname: Dorotka |
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| Snippet | Abstract The aim of our study was the evaluation of a cell-free cartilage implant that allows the recruitment of mesenchymal stem and progenitor cells by... The aim of our study was the evaluation of a cell-free cartilage implant that allows the recruitment of mesenchymal stem and progenitor cells by... |
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| SubjectTerms | Advanced Basic Science Animals Arthroplasty, Subchondral Cartilage regeneration Cartilage, Articular - drug effects Cartilage, Articular - injuries Cartilage, Articular - pathology Cartilage, Articular - surgery Cell Movement Cell-free implant Cell-Free System Cells, Cultured Chemotaxis Dentistry Extracellular Matrix - metabolism Gene Expression Regulation - drug effects Humans Hyaluronic Acid - pharmacology Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - drug effects Microfracture Polymers - chemistry Polymers - pharmacology Prostheses and Implants Regeneration - drug effects Serum Sheep Stem cells |
| Title | Regeneration of ovine articular cartilage defects by cell-free polymer-based implants |
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