The rat delta-1 and delta-2 subunits extend the excitatory amino acid receptor family

• Published in: FEBS letters Vol. 315; no. 3; pp. 318 - 322
• Main Authors: Lomeli, H., Sprengel, R., Laurie, D.J., Köhr, G., Herb, A., Seeburg, P.H., Wisden, W.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 11-01-1993; Elsevier
• Subjects: Amino Acid Sequence; Aminoacid receptors (glycine, glutamate, gaba); Animals; Autoradiography; Base Sequence; Biological and medical sciences; Brain - metabolism; Cell receptors; Cell structures and functions; DNA; Fundamental and applied biological sciences. Psychology; Glutamate receptor; In Situ Hybridization; Molecular and cellular biology; Molecular Sequence Data; Polymerase Chain Reaction; Purkinje cell; Rat brain; Rats; Receptors, Amino Acid - genetics; Receptors, Amino Acid - metabolism; RNA, Messenger - metabolism; Sequence Homology, Amino Acid; Glutamate receptor; Purkinje cell; Rat brain; Vertebrata; Mammalia; Messenger RNA; Rat; Rodentia; Sequence alignment; Purkinje neuron; Gene expression; Glutamate; Subunit; Brain (vertebrata); Biological receptor
• ISSN: 0014-5793; 1873-3468
• DOI: 10.1016/0014-5793(93)81186-4

We have characterized a second member (delta-2) of a new class of subunits for the ligand-gated excitatory amino acid receptor superfamily. The sequence of delta-2 exhibits an average identity of 25% and 18.5% to the non-NMDA and NMDA receptor subunits, respectively. The rat delta-2 gene is expressed predominantly in Purkinje cells of the cerebellum whereas only low levels of delta-1 transcripts are found in the adult brain. However, delta-1 gene expression undergoes a pronounced developmental peak, with particularly high mRNA levels in the caudate putamen of late embryonic/early postnatal stages.