Multiple evanescent white dot syndrome following rabies vaccination: a case report

• Published in: BMC ophthalmology Vol. 18; no. 1; p. 312
• Main Authors: Yang, Jia-Song, Chen, Chun-Li, Hu, Yu-Zhang, Zeng, Rui
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 07-12-2018; BioMed Central; BMC
• Subjects: Case Report; Case reports; Electrophysiology; Family medical history; Hepatitis; Medical imaging; Multiple evanescent white dot syndrome; Ophthalmology; Rabies; Rabies vaccine; Tomography; Tropical diseases; Vaccination; Vaccination/adverse events; Vaccines; China; Vaccination/adverse events; Multiple evanescent white dot syndrome; Rabies vaccine
• ISSN: 1471-2415; 1471-2415
• DOI: 10.1186/s12886-018-0968-y

To report a case of multiple evanescent white dot syndrome (MEWDS) following simultaneous rabies vaccination.
Review of the clinical, laboratory, photographic, optical coherence tomographic (OCT), fundus autofluorescent, angiographic, electrophysiologic, and perimetric records of a patient suffering from MEWDS.
A healthy 33-year-old Chinese female suffering from rapidly progressive visual loss of her left eye associated with photopsia and a para-central scotoma, seven days after receiving simultaneous rabies vaccination. Both anterior segments and fundus examination were unremarkable. The findings on OCT, electrophysiology, and perimetry were pathognomonic for MEWDS.
The clinical presentation and the benign course were consistent with the diagnosis of MEWDS. No other events could be identified as a cause, other than the rabies vaccination. This case may suggest an autoimmune basis for MEWDS in predisposed patients.