Elucidating the putative link between prefrontal neurotransmission, functional connectivity, and affective symptoms in irritable bowel syndrome

Altered neural mechanisms are well-acknowledged in irritable bowel syndrome (IBS), a disorder of brain-gut-communication highly comorbid with anxiety and depression. As a key hub in corticolimbic inhibition, medial prefrontal cortex (mPFC) may be involved in disturbed emotion regulation in IBS. Howe...

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Bibliographic Details
Published in:	Scientific reports Vol. 9; no. 1; p. 13590
Main Authors:	Icenhour, Adriane, Tapper, Sofie, Bednarska, Olga, Witt, Suzanne T., Tisell, Anders, Lundberg, Peter, Elsenbruch, Sigrid, Walter, Susanna
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 19-09-2019 Nature Publishing Group
Subjects:	140/131 59/36 59/57 631/477/2811 692/1807/4024 Adult Affective Symptoms - diagnostic imaging Affective Symptoms - etiology Affective Symptoms - metabolism Anxiety Brain mapping Case-Control Studies Cortex (cingulate) Female Functional magnetic resonance imaging gamma-Aminobutyric Acid - metabolism Glutamic Acid - metabolism Glutamine Glutamine - metabolism Humanities and Social Sciences Humans Intestine Irritable bowel syndrome Irritable Bowel Syndrome - diagnostic imaging Irritable Bowel Syndrome - metabolism Irritable Bowel Syndrome - psychology Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Mental depression multidisciplinary Neural networks Neuroimaging Neurotransmission Prefrontal cortex Prefrontal Cortex - diagnostic imaging Prefrontal Cortex - metabolism Science Science (multidisciplinary) Young Adult γ-Aminobutyric acid
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