Chitosan-Based Ciprofloxacin Extended Release Systems: Combined Synthetic and Pharmacological (In Vitro and In Vivo) Studies

Ciprofloxacin is one of the most effective antibiotics, but it is characterized by a range of side effects. Elaboration of drug-releasing systems which allow to diminish toxicity of ciprofloxacin is a challenging task in medicinal chemistry. The current study is focused on development of new ciprofl...

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Bibliographic Details
Published in:	Molecules (Basel, Switzerland) Vol. 27; no. 24; p. 8865
Main Authors:	Egorov, Anton R, Kurliuk, Aleh V, Rubanik, Vasili V, Kirichuk, Anatoly A, Khubiev, Omar, Golubev, Roman, Lobanov, Nikolai N, Tskhovrebov, Alexander G, Kritchenkov, Andreii S
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01-12-2022 MDPI
Subjects:	Acoustics Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial activity Antibiotics Antiinfectives and antibacterials Aqueous solutions Biocompatibility Biopolymers Carbodiimide Chemistry, Pharmaceutical Chitosan Chitosan - chemistry Chitosan - pharmacology Ciprofloxacin Ciprofloxacin - chemistry Ciprofloxacin - pharmacology Conjugation Drug Liberation In vivo methods and tests Infectious diseases Molecular weight Nanoparticles Nanoparticles - chemistry Polymers Rats Self-assembly Side effects Subacute toxicity Ultrasonic imaging antibacterial activity chitosan ciprofloxacin
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