Characterization of thalassemia major and diabetes mellitus patients at a reference center in Brazil
This is a quantitative transversal study that aimed to analyze the sociodemographic and clinical characteristics of thalassemia major patients with and without diabetes mellitus. The cohort consisted of 31 thalassemia major patients from a reference center of treatment in Brazil in 2016. The data we...
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| Published in: | Hematology, Transfusion and Cell Therapy Vol. 41; no. 2; pp. 139 - 144 |
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| Format: | Journal Article |
| Language: | English |
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Brazil
Sociedade Brasileira de Hematologia e Hemoterapia
01-04-2019
Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular (ABHH) Elsevier |
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| Abstract | This is a quantitative transversal study that aimed to analyze the sociodemographic and clinical characteristics of thalassemia major patients with and without diabetes mellitus.
The cohort consisted of 31 thalassemia major patients from a reference center of treatment in Brazil in 2016. The data were obtained from an interview using a questionnaire containing demographic and clinical variables. The results show that 16.1% of the participants with thalassemia major had diabetes mellitus. The participants' ages ranged from 20 to 48 years, with an average of 35 years, mostly students and starting in the formal job market. The most commonly used treatment was the oral desferasirox and the transfusion treatment interval was 15-22 days.
Patients with thalassemia major and diabetes mellitus presented altered values of fasting glycemia, serum alanine transaminase, magnetic resonance imaging and bone densitometry.
It was concluded that knowledge of the characteristics of this population contributes in the proposal of effective educational strategies in light of the complexity of care and the progression of the disease. |
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| AbstractList | OBJECTIVEThis is a quantitative transversal study that aimed to analyze the sociodemographic and clinical characteristics of thalassemia major patients with and without diabetes mellitus. METHODThe cohort consisted of 31 thalassemia major patients from a reference center of treatment in Brazil in 2016. The data were obtained from an interview using a questionnaire containing demographic and clinical variables. The results show that 16.1% of the participants with thalassemia major had diabetes mellitus. The participants' ages ranged from 20 to 48 years, with an average of 35 years, mostly students and starting in the formal job market. The most commonly used treatment was the oral desferasirox and the transfusion treatment interval was 15-22 days. RESULTSPatients with thalassemia major and diabetes mellitus presented altered values of fasting glycemia, serum alanine transaminase, magnetic resonance imaging and bone densitometry. CONCLUSIONIt was concluded that knowledge of the characteristics of this population contributes in the proposal of effective educational strategies in light of the complexity of care and the progression of the disease. Objective: This is a quantitative transversal study that aimed to analyze the sociodemographic and clinical characteristics of thalassemia major patients with and without diabetes mellitus. Method: The cohort consisted of 31 thalassemia major patients from a reference center of treatment in Brazil in 2016. The data were obtained from an interview using a questionnaire containing demographic and clinical variables. The results show that 16.1% of the participants with thalassemia major had diabetes mellitus. The participants’ ages ranged from 20 to 48 years, with an average of 35 years, mostly students and starting in the formal job market. The most commonly used treatment was the oral desferasirox and the transfusion treatment interval was 15–22 days. Results: Patients with thalassemia major and diabetes mellitus presented altered values of fasting glycemia, serum alanine transaminase, magnetic resonance imaging and bone densitometry. Conclusion: It was concluded that knowledge of the characteristics of this population contributes in the proposal of effective educational strategies in light of the complexity of care and the progression of the disease. Keywords: Thalassemia, Beta-thalassemia, Diabetes mellitus, Iron overload This is a quantitative transversal study that aimed to analyze the sociodemographic and clinical characteristics of thalassemia major patients with and without diabetes mellitus. The cohort consisted of 31 thalassemia major patients from a reference center of treatment in Brazil in 2016. The data were obtained from an interview using a questionnaire containing demographic and clinical variables. The results show that 16.1% of the participants with thalassemia major had diabetes mellitus. The participants' ages ranged from 20 to 48 years, with an average of 35 years, mostly students and starting in the formal job market. The most commonly used treatment was the oral desferasirox and the transfusion treatment interval was 15-22 days. Patients with thalassemia major and diabetes mellitus presented altered values of fasting glycemia, serum alanine transaminase, magnetic resonance imaging and bone densitometry. It was concluded that knowledge of the characteristics of this population contributes in the proposal of effective educational strategies in light of the complexity of care and the progression of the disease. ABSTRACT Objective: This is a quantitative transversal study that aimed to analyze the sociodemographic and clinical characteristics of thalassemia major patients with and without diabetes mellitus. Method: The cohort consisted of 31 thalassemia major patients from a reference center of treatment in Brazil in 2016. The data were obtained from an interview using a questionnaire containing demographic and clinical variables. The results show that 16.1% of the participants with thalassemia major had diabetes mellitus. The participants' ages ranged from 20 to 48 years, with an average of 35 years, mostly students and starting in the formal job market. The most commonly used treatment was the oral desferasirox and the transfusion treatment interval was 15-22 days. Results: Patients with thalassemia major and diabetes mellitus presented altered values of fasting glycemia, serum alanine transaminase, magnetic resonance imaging and bone densitometry. Conclusion: It was concluded that knowledge of the characteristics of this population contributes in the proposal of effective educational strategies in light of the complexity of care and the progression of the disease. |
| Author | Gonçalves, Claudio Vinicius Teixeira, Carla Regina de Souza Zanetti, Maria Lúcia Olivatto, Gabriela Marsola Sisdelli, Marcela Ganzella Silveira, Renata Cristina de Campos Pereira |
| AuthorAffiliation | a Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo (EERP-USP), Ribeirão Preto, SP, Brazil b Instituto de Ciências Matemáticas e de Computação da Universidade de São Paulo (ICMC-USP), São Carlos, SP, Brazil |
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| Author_xml | – sequence: 1 givenname: Gabriela Marsola surname: Olivatto fullname: Olivatto, Gabriela Marsola email: gabriela.olivatto@usp.br organization: Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo (EERP-USP), Ribeirão Preto, SP, Brazil. Electronic address: gabriela.olivatto@usp.br – sequence: 2 givenname: Carla Regina de Souza surname: Teixeira fullname: Teixeira, Carla Regina de Souza organization: Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo (EERP-USP), Ribeirão Preto, SP, Brazil – sequence: 3 givenname: Marcela Ganzella surname: Sisdelli fullname: Sisdelli, Marcela Ganzella organization: Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo (EERP-USP), Ribeirão Preto, SP, Brazil – sequence: 4 givenname: Maria Lúcia surname: Zanetti fullname: Zanetti, Maria Lúcia organization: Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo (EERP-USP), Ribeirão Preto, SP, Brazil – sequence: 5 givenname: Renata Cristina de Campos Pereira surname: Silveira fullname: Silveira, Renata Cristina de Campos Pereira organization: Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo (EERP-USP), Ribeirão Preto, SP, Brazil – sequence: 6 givenname: Claudio Vinicius surname: Gonçalves fullname: Gonçalves, Claudio Vinicius organization: Instituto de Ciências Matemáticas e de Computação da Universidade de São Paulo (ICMC-USP), São Carlos, SP, Brazil |
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| Keywords | Iron overload Beta-thalassemia Thalassemia Diabetes mellitus |
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| References | Vardaki, MA; Philalithis, AE; Vlachonikolis, I 2004; 18 Cappellini, MD; Cohen, A; Porter, J; Taher, A; Viprakasit, V 2014 Au, WY; Lam, WW; Chu, W; Tam, S; Wong, WK; Liang, R 2008; 93 Ladis, V; Chouliaras, G; Berdoukas, V; Chatziliami, A; Fragodimitri, C; Karabatsos, F 2011; 86 Aimiuwu, E 2013 Thuret, I; Pondarré, C; Loundou, A; Steschenko, D; Girot, R; Bachir, D 2010; 95 De Sanctis, V; Soliman, AT; Wali, Y; Elsedfy, H; Daar, S; Al-Yaarubi, SA 2015; 12 de Assis, RA; Ribeiro, AA; Kay, FU; Rosemberg, LA; Nomura, CH; Loggetto, SR 2012; 81 Old, J; Harteveld, CL; Traeger-Synodinos, J; Petrou, M; Angastiniotis, M; Galanello, R 2013 Orlando, GM; Naoum, PC; Siqueira, FA; Bonini-Domingos, CR 2000; 22 Ganzella, M; Zago, MM 2011; 19 2016 Matter, RM; Allam, KE; Sadony, AM 2010; 2 Au, WY; Lee, V; Lau, CW; Yau, J; Chan, D; Chan, EY 2011; 17 Hashemizadeh, H; Noori, R; Kolagari, S 2012; 2 Skordis, N; Ioannou, YS; Kyriakou, A; Savva, SC; Efstathiou, E; Savvides, I 2008; 6 Tzoulis, P; Shah, F; Jones, R; Prescott, E; Barnard, M 2014; 38 |
| References_xml | – volume: 93 start-page: 116 issue: 1 year: 2008 end-page: 119 article-title: A T2* magnetic resonance imaging study of pancreatic iron overload in thalassemia major publication-title: Haematologica contributor: fullname: Au, WY; Lam, WW; Chu, W; Tam, S; Wong, WK; Liang, R – volume: 81 start-page: 1465 issue: 7 year: 2012 end-page: 1470 article-title: Pancreatic iron stores assessed by magnetic resonance imaging (MRI) in beta thalassemic publication-title: Eur J Radiol contributor: fullname: de Assis, RA; Ribeiro, AA; Kay, FU; Rosemberg, LA; Nomura, CH; Loggetto, SR – volume: 19 start-page: 968 issue: 4 year: 2011 end-page: 976 article-title: A experiência dos talassêmicos adultos ao tratamento publication-title: Rev Latino-Am Enfermagem contributor: fullname: Ganzella, M; Zago, MM – volume: 17 start-page: 261 issue: 4 year: 2011 end-page: 266 article-title: A synopsis of current care of thalassaemia major patients in Hong Kong publication-title: Hong Kong Med J contributor: fullname: Au, WY; Lee, V; Lau, CW; Yau, J; Chan, D; Chan, EY – volume: 6 start-page: 144 issue: Suppl. 1 year: 2008 end-page: 148 article-title: Effect of bisphosphonate treatment on bone mineral density in patients with thalassaemia major publication-title: Pediatr Endocrinol Rev contributor: fullname: Skordis, N; Ioannou, YS; Kyriakou, A; Savva, SC; Efstathiou, E; Savvides, I – year: 2014 publication-title: Guidelines for the management of transfusion dependent thalassemia contributor: fullname: Cappellini, MD; Cohen, A; Porter, J; Taher, A; Viprakasit, V – year: 2013 publication-title: A guide for the haemoglobinopathy nurse, no. 16 contributor: fullname: Aimiuwu, E – volume: 18 start-page: 177 issue: December (2) year: 2004 end-page: 187 article-title: Factors associated with the attitudes and expectations of patients suffering from beta-thalassaemia: a cross-sectional study publication-title: Scand J Caring Sci contributor: fullname: Vardaki, MA; Philalithis, AE; Vlachonikolis, I – volume: 2 start-page: 2310 year: 2010 article-title: Gradient-echo magnetic resonance imaging study of pancreatic iron overload in young Egyptian beta-thalassemia major patients and effect of splenectomy publication-title: Diabetol Metab Syndr contributor: fullname: Matter, RM; Allam, KE; Sadony, AM – year: 2016 publication-title: Talassemia – volume: 38 start-page: 104 issue: 2 year: 2014 end-page: 110 article-title: Joint diabetes thalassaemia clinic: an effective new model of care publication-title: Hemoglobin contributor: fullname: Tzoulis, P; Shah, F; Jones, R; Prescott, E; Barnard, M – volume: 2 start-page: 171 issue: 4 year: 2012 end-page: 177 article-title: Assessment hepatomegaly and liver enzymes in 100 patients with beta thalassemia major in Mashhad, Iran publication-title: Iran J Pediatr Hematol Oncol contributor: fullname: Hashemizadeh, H; Noori, R; Kolagari, S – volume: 95 start-page: 724 issue: 5 year: 2010 end-page: 729 article-title: Complications and treatment of patients with β-thalassemia in France: results of the National Registry publication-title: Haematologica contributor: fullname: Thuret, I; Pondarré, C; Loundou, A; Steschenko, D; Girot, R; Bachir, D – year: 2013 publication-title: Prevention of thalassaemias and other haemoglobin disorders, vol. 1: principles contributor: fullname: Old, J; Harteveld, CL; Traeger-Synodinos, J; Petrou, M; Angastiniotis, M; Galanello, R – volume: 22 start-page: 111 issue: 2 year: 2000 end-page: 121 article-title: Diagnóstico laboratorial de hemoglobinopatias em populações diferenciadas publication-title: Rev Bras Hematol Hemoter contributor: fullname: Orlando, GM; Naoum, PC; Siqueira, FA; Bonini-Domingos, CR – volume: 86 start-page: 332 issue: 4 year: 2011 end-page: 338 article-title: Survival in a large cohort of Greek patients with transfusion-dependent beta thalassaemia and mortality ratios compared to the general population publication-title: Eur J Haematol contributor: fullname: Ladis, V; Chouliaras, G; Berdoukas, V; Chatziliami, A; Fragodimitri, C; Karabatsos, F – volume: 12 start-page: 313 issue: 3 year: 2015 end-page: 322 article-title: Selected highlights of the VIII internacional symposium of clinicians for endocrinopathies in thalassemia and adolescent medicine (ICET-A) on growth puberty and endocrine complications in thalassaemia. Auditorium of the Sultan Qaboos University (SQU) Muscat, 20th of December 2014 publication-title: Pediatr Endocrinol Rev contributor: fullname: De Sanctis, V; Soliman, AT; Wali, Y; Elsedfy, H; Daar, S; Al-Yaarubi, SA |
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| Title | Characterization of thalassemia major and diabetes mellitus patients at a reference center in Brazil |
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