An Implanted Closed-loop Chip System for Heart Rate Control： System Design and Effects in Conscious Rats

• Published in: Journal of biomedical research Vol. 24; no. 2; pp. 107 - 114
• Main Authors: Zhou, Yuxuan, Yuan, Yuan, Gao, Juan, Yang, Ling, Zhang, Feng, Zhu, Guoqing, Gao, Xingya
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01-03-2010; Editorial Department of Journal of Biomedical Research
• Subjects: closed-loop regulation; heart rate; implanted chip system; Remote-controlled animal; Research Paper; set point; vagus nerve stimulation; 人力资源; 植入式; 率控制; 系统单晶片; 芯片系统; 设计规范; Remote-controlled animal; set point; heart rate; vagus nerve stimulation; implanted chip system; closed-loop regulation
• ISSN: 1674-8301
• DOI: 10.1016/S1674-8301(10)60018-8

Objective： To evaluate the efficiency of an implanted chip system for the control of heart rate （HR）. Methods： The HR was recorded in six conscious Sprague-Dawley （SD） rats. An implanted chip system was designed to regulate the HR by stimulating the right cervical vagus nerve according to the feedback of real time HR. Each rat was subjected to 30-min regulation and 30-min recovery. The change of HR during the regulation period was compared with the control. The ECG was recorded during the experiment for 24 h. Results： The ECG signals were successfully recorded during the experiment. The HR was significantly decreased during the period of regulation compared with control （-79.3 ± 34.5, P 〈 0.01, n = 6） and then recovered to normal after regulation. Conclusion： The described implanted chip system can regulate the HR to a designated set point.