Effects of the acute and chronic restraint stresses on the central histaminergic neuron system of Fischer rat

• Published in: Neuroscience letters Vol. 262; no. 2; pp. 143 - 145
• Main Authors: Ito, Chihiro, Shen, Haowei, Toyota, Hiroshi, Kubota, Yasuhiko, Sakurai, Eiko, Watanabe, Takehiko, Sato, Mitsumoto
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 05-03-1999; Elsevier
• Subjects: Acute Disease; Analysis of Variance; Animals; Behavioral psychophysiology; Biological and medical sciences; Brain - cytology; Brain - enzymology; Brain - metabolism; Chronic Disease; Corpus Striatum - enzymology; Corpus Striatum - metabolism; Diencephalon - enzymology; Diencephalon - metabolism; Fischer rat brain; Fundamental and applied biological sciences. Psychology; Histamine; Histamine - metabolism; Histamine N-methyltransferase; Histamine N-Methyltransferase - metabolism; Male; Neurotransmission and behavior; Nucleus Accumbens - enzymology; Nucleus Accumbens - metabolism; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Rats; Rats, Inbred F344; Restraint stresses; Restraint, Physical; Space life sciences; Stress vulnerability; Stress, Physiological - enzymology; Stress, Physiological - metabolism; Stress, Physiological - physiopathology; Histamine; Fischer rat brain; Histamine N-methyltransferase; Restraint stresses; Stress vulnerability; Rat; Enzyme; Transferases; Rodentia; Central nervous system; Vertebrata; Histaminergic neuron; Restraint stress; Mammalia; Methyltransferases; Enzymatic activity; Animal; Brain (vertebrata)
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/S0304-3940(99)00052-X

The effects of acute and chronic restraint stresses on the brain histamine level and histamine
N-methyltransferase activity in Fischer rat brain were studied. The acute restraint stress increased the histamine levels in the diencephalon and nucleus accumbens, and increased the histamine
N-methyltransferase activities in the nucleus accumbens and striatum. The chronic restraint stress also increased histamine
N-methyltransferase activities in the nucleus accumbens and striatum. These results indicate that the acute and chronic restraint stresses increase the brain histamine turnover, which may partly relate to the vulnerability for stress-induced anxiety and depression.