Extrapulmonary onset manifestations of COVID-19

Coronavirus disease (COVID-19) usually starts with pulmonary signs and symptoms. However, in some cases, the initial clinical presentations are extrapulmonary. This literature review aimed at summarizing and discussing the extrapulmonary onset manifestations of COVID-19. The most frequent initial ex...

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Published in:Clinics (São Paulo, Brazil) Vol. 76; p. e2900
Main Authors: Finsterer, Josef, Scorza, Fulvio A., Scorza, Carla A., Fiorini, Ana C.
Format: Journal Article
Language:English
Published: United States Elsevier España, S.L.U 01-01-2021
Faculdade de Medicina / USP
Elsevier España
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Abstract Coronavirus disease (COVID-19) usually starts with pulmonary signs and symptoms. However, in some cases, the initial clinical presentations are extrapulmonary. This literature review aimed at summarizing and discussing the extrapulmonary onset manifestations of COVID-19. The most frequent initial extrapulmonary manifestations include hypogeusia, hyposmia, non-specific abdominal symptoms, corneal congestion, and deep venous thrombosis. Several rarer extrapulmonary manifestations in locations such as the brain, peripheral nerves, muscles, eyes, ears, myocardium, intestines, skin, or vessels have been additionally reported as onset presentations of COVID-19. In conclusion, it is crucial for clinicians and health care providers to consider extrapulmonary presentations at the onset of COVID-19 to avoid overlooking the infection and contributing to the spread of the disease.
AbstractList Coronavirus disease (COVID-19) usually starts with pulmonary signs and symptoms. However, in some cases, the initial clinical presentations are extrapulmonary. This literature review aimed at summarizing and discussing the extrapulmonary onset manifestations of COVID-19. The most frequent initial extrapulmonary manifestations include hypogeusia, hyposmia, non-specific abdominal symptoms, corneal congestion, and deep venous thrombosis. Several rarer extrapulmonary manifestations in locations such as the brain, peripheral nerves, muscles, eyes, ears, myocardium, intestines, skin, or vessels have been additionally reported as onset presentations of COVID-19. In conclusion, it is crucial for clinicians and health care providers to consider extrapulmonary presentations at the onset of COVID-19 to avoid overlooking the infection and contributing to the spread of the disease.
ArticleNumber e2900
Author Fiorini, Ana C.
Scorza, Carla A.
Finsterer, Josef
Scorza, Fulvio A.
AuthorAffiliation II Disciplina de Neurociencia, Escola Paulista de Medicina/Universidade Federal de Sao Paulo (EPM/UNIFESP), Sao Paulo, SP, BR
I Klinik Landstrasse, Messerli Institute, Vienna, Austria
III Programa de Estudos Pos-Graduados em Fonoaudiologia, Pontificia Universidade Catolica de Sao Paulo (PUC-SP), Sao Paulo, SP, BR, Departamento de Fonoaudiologia, Escola Paulista de Medicina/Universidade Federal de Sao Paulo (EPM/UNIFESP), Sao Paulo, SP, BR
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Keywords COVID-19
SARS-CoV-2
Variability
Clinical Presentation
Onset
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SubjectTerms Clinical Presentation
COVID-19
Humans
Lung
MEDICINE, GENERAL & INTERNAL
Onset
Review
SARS-CoV-2
Variability
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Title Extrapulmonary onset manifestations of COVID-19
URI https://dx.doi.org/10.6061/clinics/2021/e2900
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