Specificity of the chromophore-binding site in human cone opsins

The variable composition of the chromophore-binding pocket in visual receptors is essential for vision. The visual phototransduction starts with the cis-trans isomerization of the retinal chromophore upon absorption of photons. Despite sharing the common 11-cis-retinal chromophore, rod and cone phot...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 294; no. 15; pp. 6082 - 6093
Main Authors:	Katayama, Kota, Gulati, Sahil, Ortega, Joseph T., Alexander, Nathan S., Sun, Wenyu, Shenouda, Marina M., Palczewski, Krzysztof, Jastrzebska, Beata
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 12-04-2019 American Society for Biochemistry and Molecular Biology
Subjects:	11-cis-6mr-retinal Cone Opsins - chemistry Cone Opsins - genetics Cone Opsins - metabolism G protein-coupled receptor (GPCR) HEK293 Cells Humans membrane protein Models, Molecular Molecular Biophysics photoreceptor Protein Binding protein structure retinal pigment Retinaldehyde - chemistry Retinaldehyde - metabolism retinoid rhodopsin vision rhodopsin protein structure vision 11-cis-6mr-retinal photoreceptor G protein-coupled receptor (GPCR) membrane protein retinal pigment retinoid
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