Enhanced germinal center reaction by targeting vaccine antigen to major histocompatibility complex class II molecules

Enhancing the germinal center (GC) reaction is a prime objective in vaccine development. Targeting of antigen to MHCII on APCs has previously been shown to increase antibody responses, but the underlying mechanism has been unclear. We have here investigated the GC reaction after targeting antigen to...

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Bibliographic Details

Published in:	npj vaccines Vol. 4; no. 1; p. 9
Main Authors:	Andersen, Tor Kristian, Huszthy, Peter C., Gopalakrishnan, Ramakrishna P., Jacobsen, Johanne T., Fauskanger, Marte, Tveita, Anders A., Grødeland, Gunnveig, Bogen, Bjarne
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 11-02-2019 Nature Publishing Group
Subjects:	631/250/2152/2153/1291 631/250/2152/2153/1982 631/250/255/1578 631/250/590/1991 Antigens Biomedical and Life Sciences Biomedicine Immunoglobulins Infectious Diseases Medical Microbiology Multiple myeloma Public Health Vaccine Vaccines Virology
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