Use of cervicovaginal PAMG-1 protein as a predictor of delivery within seven days in pregnancies at risk of premature birth

• Published in: BMC pregnancy and childbirth Vol. 17; no. 1; p. 246
• Main Authors: Çekmez, Yasemin, Kıran, Gürkan, Haberal, Esra Tuştaş, Dizdar, Merve
• Format: Journal Article
• Language: English
• Published: England BioMed Central 26-07-2017; BMC
• Subjects: Biomarkers; Biomarkers - analysis; Cervical Length Measurement - nursing; Cervix Uteri - metabolism; Cervix Uteri - secretion; Committees; Female; Fibronectin; Fibronectins - analysis; Gynecology; Humans; Infections; Insulin-Like Growth Factor Binding Protein 1 - analysis; Intensive care; Membranes; Newborn babies; Obstetric Labor, Premature - diagnosis; Obstetric Labor, Premature - metabolism; Obstetrics; PAMG-1; Patients; Pregnancy; Premature birth; Prematurity; Prenatal Care - methods; Preterm labour; Prospective Studies; Risk Factors; Systematic review; Ultrasonic imaging; Istanbul Turkey; Preterm labour; PAMG-1; Prematurity; Fibronectin
• ISSN: 1471-2393; 1471-2393
• DOI: 10.1186/s12884-017-1427-0

To investigate the utility of vaginal placental alpha microglobulin-1 (PAMG-1) protein as a predictor of preterm delivery within 7 days in pregnancies at risk of premature birth.
This prospective study was performed in women at risk of premature birth. The levels of vaginal PAMG-1 and foetal fibronectin (fFN) and the transvaginal cervical length measurement (CLM) were investigated and compared.
Seventy-two pregnant women were included in this study. The sensitivities of PAMG-1, fFN and CLM were 73.3, 73.6%, and 52.9%, respectively, while the specificities of PAMG-1, fFN and CLM were 92.9%, 94.3%, and 90.9%, respectively. The positive predictive values of PAMG-1, fFN and CLM were 73.3%, 82.3%, and 64.2%, respectively, and the negative predictive values of PAMG-1, fFN and CLM were 92.9%, 90.9%, and 86.2%, respectively.
The diagnostic accuracy of PAMG-1 is similar to that of fFN in terms of preterm labour detection within 7 days.