Characteristics of patients with oseltamivir-resistant pandemic (H1N1) 2009, United States

• Published in: Emerging infectious diseases Vol. 17; no. 2; pp. 255 - 257
• Main Authors: Graitcer, Samuel B, Gubareva, Larisa, Kamimoto, Laurie, Doshi, Saumil, Vandermeer, Meredith, Louie, Janice, Waters, Christine, Moore, Zack, Sleeman, Katrina, Okomo-Adhiambo, Margaret, Marshall, Steven A, St George, Kirsten, Pan, Chao Yang, LaPlante, Jennifer M, Klimov, Alexander, Fry, Alicia M
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01-02-2011; Centers for Disease Control and Prevention
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; antimicrobial resistance; Antiviral agents; Antiviral Agents - administration & dosage; Antiviral Agents - pharmacology; Child; Child, Preschool; Disease susceptibility; Dispatch; Drug Resistance, Viral; Enzyme Inhibitors - administration & dosage; Enzyme Inhibitors - pharmacology; Epidemics; Female; H1N1 subtype; Health aspects; Humans; Immunocompromised Host; Infant; influenza; influenza A; Influenza A Virus, H1N1 Subtype - drug effects; Influenza A Virus, H1N1 Subtype - pathogenicity; Influenza, Human - epidemiology; Influenza, Human - mortality; Influenza, Human - physiopathology; Influenza, Human - virology; Male; Medical research; Medicine, Experimental; Middle Aged; Neuraminidase - antagonists & inhibitors; Oseltamivir; Oseltamivir - administration & dosage; Oseltamivir - pharmacology; Pandemics; Population Surveillance - methods; Public health; Swine influenza; United States - epidemiology; viruses; Young Adult; United States
• ISSN: 1080-6040; 1080-6059
• DOI: 10.3201/eid1702.101724

During April 2009-June 2010, thirty-seven (0.5%) of 6,740 pandemic (H1N1) 2009 viruses submitted to a US surveillance system were oseltamivir resistant. Most patients with oseltamivir-resistant infections were severely immunocompromised (76%) and had received oseltamivir before specimen collection (89%). No evidence was found for community circulation of resistant viruses; only 4 (unlinked) patients had no oseltamivir exposure.