Study protocol for a multicenter randomized controlled trial to compare the efficacy of end-ischemic dual hypothermic oxygenated machine perfusion with static cold storage in preventing non-anastomotic biliary strictures after transplantation of liver grafts donated after circulatory death: DHOPE-DCD trial

The major concern in liver transplantation of grafts from donation after circulatory death (DCD) donors remains the high incidence of non-anastomotic biliary strictures (NAS). Machine perfusion has been proposed as an alternative strategy for organ preservation which reduces ischemia-reperfusion inj...

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Bibliographic Details
Published in:	BMC gastroenterology Vol. 19; no. 1; p. 40
Main Authors:	van Rijn, Rianne, van den Berg, Aad P, Erdmann, Joris I, Heaton, Nigel, van Hoek, Bart, de Jonge, Jeroen, Leuvenink, Henri G D, Mahesh, Shekar V K, Mertens, Sarah, Monbaliu, Diethard, Muiesan, Paolo, Perera, M Thamara P R, Polak, Wojciech G, Rogiers, Xavier, Troisi, Roberto I, de Vries, Yvonne, Porte, Robert J
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 12-03-2019 BioMed Central BMC
Subjects:	Adult Analysis Bile ducts Brain death Care and treatment Cholestasis - prevention & control Clinical trials Cost Cryopreservation Death Donation after circulatory death Donations Double-Blind Method Endothelium Gastroenterology Humans Hypothermia, Induced - methods Incidence Ischemia Ischemic type biliary lesions Kidneys Liver Liver transplantation Liver Transplantation - adverse effects Medical research Mitochondria Multicenter Studies as Topic Organ Preservation - methods Organ transplantation Perfusion Perfusion - methods Postoperative Complications Preservation Prevention Randomized Controlled Trials as Topic Reperfusion Reperfusion injury Reperfusion Injury - prevention & control Rodents Stricture Studies Study Protocol Surgery Survival Tissue and Organ Procurement - methods Tissue donation Tissue Donors Transplants & implants United States > US Adult Donation after circulatory death Cost Survival Ischemic type biliary lesions Incidence
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