RNA Secondary Structure-Based Design of Antisense Peptide Nucleic Acids for Modulating Disease-Associated Aberrant Tau Pre-mRNA Alternative Splicing

Alternative splicing of tau pre-mRNA is regulated by a 5' splice site (5'ss) hairpin present at the exon 10-intron 10 junction. Single mutations within the hairpin sequence alter hairpin structural stability and/or the binding of splicing factors, resulting in disease-causing aberrant spli...

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Bibliographic Details
Published in:	Molecules (Basel, Switzerland) Vol. 24; no. 16; p. 3020
Main Authors:	Ong, Alan Ann Lerk, Tan, Jiazi, Bhadra, Malini, Dezanet, Clément, Patil, Kiran M, Chong, Mei Sian, Kierzek, Ryszard, Decout, Jean-Luc, Roca, Xavier, Chen, Gang
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 20-08-2019 MDPI
Subjects:	Alternative Splicing antisense Antisense therapy Binding Cell culture Conjugation Disease Electrophoretic mobility exon inclusion exon skipping Exons HEK293 Cells Humans Molecular Conformation mRNA Mutants Mutation Neamine Nucleic acids Oligonucleotides, Antisense - genetics Peptide nucleic acids Peptide Nucleic Acids - genetics Peptides Plasmids PNA Protein structure Proteins Reagents Regulatory sequences RNA Precursors RNA Splice Sites RNA structure RNA, Messenger - genetics Secondary structure Splicing Splicing factors strand invasion Structural stability tau Proteins - genetics Transfection PNA strand invasion exon inclusion exon skipping RNA structure antisense
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