Engineering of a Potent Recombinant Lectin-Toxin Fusion Protein to Eliminate Human Pluripotent Stem Cells

The use of human pluripotent stem cells (hPSCs) such as human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) in regenerative medicine is hindered by their tumorigenic potential. Previously, we developed a recombinant lectin-toxin fusion protein of the hPSC-specific le...

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Bibliographic Details
Published in:	Molecules (Basel, Switzerland) Vol. 22; no. 7; p. 1151
Main Authors:	Tateno, Hiroaki, Saito, Sayoko
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 10-07-2017 MDPI
Subjects:	ADP Ribose Transferases - genetics Bacterial Toxins - genetics Cell culture Cell Culture Techniques Cell Line Cell Survival Collagen - chemistry Domains Embryo cells Embryos Escherichia coli Exotoxin A Exotoxins - genetics Fibroblasts - cytology Fusion protein Glycosaminoglycans - chemistry Hepatocytes Humans lectin Lectins Lectins - genetics Mesenchyme Mixed culture Pluripotency pluripotent stem cells Pluripotent Stem Cells - cytology Proteins Pseudomonas aeruginosa Pseudomonas aeruginosa Exotoxin A Reagents Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - pharmacology Regenerative medicine Stem cells Transplantation tumorigenicity Virulence Factors - genetics tumorigenicity pluripotent stem cells lectin regenerative medicine
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