Anthracycline Cardiomyopathy Is Mediated by Depletion of the Cardiac Stem Cell Pool and Is Rescued by Restoration of Progenitor Cell Function

Anthracyclines are the most effective drugs available in the treatment of neoplastic diseases; however, they have profound consequences on the structure and function of the heart, which over time cause a cardiomyopathy that leads to congestive heart failure. Administration of doxorubicin in rats led...

Full description

Saved in:

Bibliographic Details
Published in:	Circulation (New York, N.Y.) Vol. 121; no. 2; pp. 276 - 292
Main Authors:	DE ANGELIS, Antonella, PIEGARI, Elena, URBANEK, Konrad, KAJSTURA, Jan, LERI, Annarosa, ROSSI, Francesco, ANVERSA, Piero, CAPPETTA, Donato, MARINO, Laura, FILIPPELLI, Amelia, BERRINO, Liberato, FERREIRA-MARTINS, Joao, HANQIAO ZHENG, HOSODA, Toru, ROTA, Marcello
Format:	Journal Article
Language:	English
Published:	Hagerstown, MD Lippincott Williams & Wilkins 19-01-2010
Subjects:	Animals Anthracyclines - adverse effects Biological and medical sciences Blood and lymphatic vessels Blood vessels and receptors Cardiology. Vascular system Cardiomyopathies - chemically induced Cardiomyopathies - pathology Cardiomyopathies - therapy Cardiomyopathy, Dilated - chemically induced Cardiomyopathy, Dilated - pathology Cardiomyopathy, Dilated - therapy Cell Count Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Doxorubicin - adverse effects Fundamental and applied biological sciences. Psychology Heart Failure - chemically induced Heart Failure - pathology Heart Failure - therapy Humans Medical sciences Myocytes, Cardiac Neoplasms - complications Neoplasms - drug therapy Rats Regeneration Stem Cell Transplantation Stem Cells - drug effects Stem Cells - physiology Vertebrates: cardiovascular system Antineoplastic agent Heart failure stem cells antineoplastic agents cardiotoxicity Depletion Cardiomyopathy Heart disease Stem cell Cardiovascular disease Myocardial disease Progenitor cell
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!