Antioxidant and Anti-Osteoporosis Activities of Chemical Constituents of the Stems of Zanthoxylum piperitum

• Published in: Molecules (Basel, Switzerland) Vol. 23; no. 2; p. 457
• Main Authors: Yang, Seo Young, Lee, Sang-Hyun, Tai, Bui Huu, Jang, Hae-Dong, Kim, Young Ho
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 18-02-2018; MDPI
• Subjects: Acid phosphatase; Acid phosphatase (tartrate-resistant); Acid resistance; Anti-osteoporosis; Antioxidant; Antioxidants; Antioxidants - chemistry; Antioxidants - isolation & purification; Antioxidants - therapeutic use; Biocompatibility; CUPRAC; Flavonoids; Flavonoids - chemistry; Humans; Lignans; Lignans - chemistry; ORAC; Osteoporosis; Osteoporosis - drug therapy; Oxygen Radical Absorbance Capacity; Peroxides - chemistry; Peroxyl radicals; Phenols - chemistry; Plant Extracts - chemistry; Plant Extracts - therapeutic use; Tartrate-Resistant Acid Phosphatase - chemistry; TRAP; Zanthoxylum; Zanthoxylum - chemistry; Zanthoxylum piperitum; ORAC; TRAP; Zanthoxylum piperitum; Antioxidant; CUPRAC; Anti-osteoporosis
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules23020457

Two new lignans, zanthoxyloside C (
) and zanthoxyloside D (
), together with nine known compounds comprising lignans (
-
), flavonoids (
-
), and phenolics (
-
), were isolated from the methanol extract of the stems of
All isolates were evaluated for their antioxidant and anti-osteoporotic activities using oxygen radical absorbance capacity (ORAC), cupric reducing antioxidant capacity (CUPRAC), and tartrate-resistant acid phosphatase (TRAP) assays. Compounds
-
showed peroxyl radical-scavenging capacities and
,
-
, and
showed reducing capacities. Moreover, compounds
,
-
, and
significantly suppressed TRAP activities. These results indicated that the stems of
could be an excellent source for natural antioxidant and anti-osteoporosis.