Murine coronavirus infection: a paradigm for virus-induced demyelinating disease

A variety of neurological diseases in humans, including multiple sclerosis (MS), have been postulated to have a viral etiology. The use of animal models provides insights into potential mechanism(s) involved in the disease process. The murine coronavirus-induced demyelinating disease in rodents is o...

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Bibliographic Details
Published in:	Trends in microbiology (Regular ed.) Vol. 5; no. 1; pp. 9 - 14
Main Authors:	Lane, Thomas E., Buchmeier, Michael J.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 1997 Published by Elsevier Ltd
Subjects:	Animals Chronic Disease coronavirus Coronavirus Infections - etiology Coronavirus Infections - immunology Demyelinating Diseases - epidemiology Demyelinating Diseases - etiology Demyelinating Diseases - immunology Disease Models, Animal Humans Mice Molecular Biology - methods Multiple Sclerosis - epidemiology Multiple Sclerosis - virology Murine hepatitis virus - immunology Murine hepatitis virus - pathogenicity Murine hepatitis virus - physiology Rats Virus Diseases - diagnosis Virus Diseases - genetics Virus Latency
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Summary:	A variety of neurological diseases in humans, including multiple sclerosis (MS), have been postulated to have a viral etiology. The use of animal models provides insights into potential mechanism(s) involved in the disease process. The murine coronavirus-induced demyelinating disease in rodents is one such model for demyelinating disease in humans.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 ObjectType-Feature-3 ObjectType-Review-1 tel:+1 619 784 7056, fax:+1 619 784 7369
ISSN:	0966-842X 1878-4380
DOI:	10.1016/S0966-842X(97)81768-4