The genetics and immunopathogenesis of inflammatory bowel disease

Key Points The central challenge of the intestinal immune system is balancing the need to respond to pathogens while co-existing with commensal bacteria and food antigens. Data from genome-wide association (GWA) studies support the concept that dysregulation of the normally controlled immune respons...

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Bibliographic Details
Published in:	Nature reviews. Immunology Vol. 8; no. 6; pp. 458 - 466
Main Author:	Cho, Judy H
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-06-2008 Nature Publishing Group
Subjects:	Animals Biomedical and Life Sciences Biomedicine Colitis, Ulcerative - genetics Colitis, Ulcerative - immunology Colitis, Ulcerative - metabolism Colitis, Ulcerative - pathology Crohn Disease - genetics Crohn Disease - immunology Crohn Disease - metabolism Crohn Disease - pathology Genetic aspects Genetic diversity Genetic Predisposition to Disease - genetics Genetics Health aspects Humans Immune response Immunology Inflammatory bowel diseases Inflammatory Bowel Diseases - epidemiology Inflammatory Bowel Diseases - genetics Inflammatory Bowel Diseases - immunology Inflammatory Bowel Diseases - pathology review-article Risk factors Single nucleotide polymorphisms United States
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