Direct Assessment of Single-Cell DNA Using Crudely Purified Live Cells: A Proof of Concept for Noninvasive Prenatal Definitive Diagnosis

Noninvasive testing techniques are often used for fetal diagnosis of genetic abnormalities but are limited by certain characteristics, including noninformative results. Thus, novel methods of noninvasive definitive diagnosis of fetal genetic abnormalities are needed. The aim of this study was to dev...

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Bibliographic Details
Published in:	The Journal of molecular diagnostics : JMD Vol. 22; no. 2; pp. 132 - 140
Main Authors:	Sato, Taisuke, Ito, Yuki, Samura, Osamu, Aoki, Hiroaki, Uchiyama, Toru, Okamoto, Aikou, Hata, Kenichiro
Format:	Journal Article
Language:	English Japanese
Published:	United States Elsevier Inc 01-02-2020
Subjects:	Adult Blood Cells - metabolism DNA Female Fetal Blood - cytology Fetus - cytology Gestational Age Humans Immunomagnetic Separation - methods Liquid Biopsy - methods Male Noninvasive Prenatal Testing - methods Noninvasive Prenatal Testing - standards Pregnancy Real-Time Polymerase Chain Reaction - methods Sensitivity and Specificity Single-Cell Analysis - methods Single-Cell Analysis - standards SOX Transcription Factors - genetics
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