Duffy antigen receptor for chemokines (Darc) polymorphism regulates circulating concentrations of monocyte chemoattractant protein-1 and other inflammatory mediators
To identify the genetic basis of circulating concentrations of monocyte chemoattractant protein-1 (MCP-1), we conducted genome-wide association analyses for MCP-1 in 3 independent cohorts (n = 9598). The strongest association was for serum MCP-1 with a nonsynonymous polymorphism, rs12075 (Asp42Gly)...
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| Published in: | Blood Vol. 115; no. 26; pp. 5289 - 5299 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier Inc
01-07-2010
Americain Society of Hematology American Society of Hematology |
| Series: | Plenary Paper |
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| Abstract | To identify the genetic basis of circulating concentrations of monocyte chemoattractant protein-1 (MCP-1), we conducted genome-wide association analyses for MCP-1 in 3 independent cohorts (n = 9598). The strongest association was for serum MCP-1 with a nonsynonymous polymorphism, rs12075 (Asp42Gly) in DARC, the gene for Duffy antigen receptor for chemokines, a known vascular reservoir of proinflammatory cytokines (minor allele frequency, 45.6%; P < 1.0 * 10−323). This association was supported by family-based genetic linkage at a locus encompassing the DARC gene (genome-wide P = 8.0 * 10−13). Asp42Gly accounted for approximately 20% of the variability in serum MCP-1 concentrations and also was associated with serum concentrations of interleukin-8 and RANTES. While exploring a lack of association between this polymorphism and EDTA plasma MCP-1 concentrations (P = .82), we determined that both clotting and exogenous heparan sulfate (unfractionated heparin) released substantial amounts of MCP-1 from Darc. Quantitative immunoflow cytometry failed to identify meaningful Asp42Gly-associated differences in Darc expression, suggesting that a functional change is responsible for the differential cytokine binding. We conclude that Asp42Gly is a major regulator of erythrocyte Darc-mediated cytokine binding and thereby the circulating concentrations of several proinflammatory cytokines. We have also identified for the first time 2 mechanisms for the release of reservoir chemokines with possible clinical implications. |
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| AbstractList | To identify the genetic basis of circulating concentrations of monocyte chemoattractant protein-1 (MCP-1), we conducted genome-wide association analyses for MCP-1 in 3 independent cohorts (n = 9598). The strongest association was for serum MCP-1 with a nonsynonymous polymorphism, rs12075 (Asp42Gly) in
DARC
, the gene for Duffy antigen receptor for chemokines, a known vascular reservoir of proinflammatory cytokines (minor allele frequency, 45.6%;
P
< 1.0 * 10
−323
). This association was supported by family-based genetic linkage at a locus encompassing the
DARC
gene (genome-wide
P
= 8.0 * 10
−13
). Asp42Gly accounted for approximately 20% of the variability in serum MCP-1 concentrations and also was associated with serum concentrations of interleukin-8 and RANTES. While exploring a lack of association between this polymorphism and EDTA plasma MCP-1 concentrations (
P
= .82), we determined that both clotting and exogenous heparan sulfate (unfractionated heparin) released substantial amounts of MCP-1 from Darc. Quantitative immunoflow cytometry failed to identify meaningful Asp42Gly-associated differences in Darc expression, suggesting that a functional change is responsible for the differential cytokine binding. We conclude that Asp42Gly is a major regulator of erythrocyte Darc-mediated cytokine binding and thereby the circulating concentrations of several proinflammatory cytokines. We have also identified for the first time 2 mechanisms for the release of reservoir chemokines with possible clinical implications. To identify the genetic basis of circulating concentrations of monocyte chemoattractant protein-1 (MCP-1), we conducted genome-wide association analyses for MCP-1 in 3 independent cohorts (n = 9598). The strongest association was for serum MCP-1 with a nonsynonymous polymorphism, rs12075 (Asp42Gly) in DARC, the gene for Duffy antigen receptor for chemokines, a known vascular reservoir of proinflammatory cytokines (minor allele frequency, 45.6%; P < 1.0 * 10−323). This association was supported by family-based genetic linkage at a locus encompassing the DARC gene (genome-wide P = 8.0 * 10−13). Asp42Gly accounted for approximately 20% of the variability in serum MCP-1 concentrations and also was associated with serum concentrations of interleukin-8 and RANTES. While exploring a lack of association between this polymorphism and EDTA plasma MCP-1 concentrations (P = .82), we determined that both clotting and exogenous heparan sulfate (unfractionated heparin) released substantial amounts of MCP-1 from Darc. Quantitative immunoflow cytometry failed to identify meaningful Asp42Gly-associated differences in Darc expression, suggesting that a functional change is responsible for the differential cytokine binding. We conclude that Asp42Gly is a major regulator of erythrocyte Darc-mediated cytokine binding and thereby the circulating concentrations of several proinflammatory cytokines. We have also identified for the first time 2 mechanisms for the release of reservoir chemokines with possible clinical implications. To identify the genetic basis of circulating concentrations of monocyte chemoattractant protein-1 (MCP-1), we conducted genome-wide association analyses for MCP-1 in 3 independent cohorts (n = 9598). The strongest association was for serum MCP-1 with a nonsynonymous polymorphism, rs12075 (Asp42Gly) in DARC, the gene for Duffy antigen receptor for chemokines, a known vascular reservoir of proinflammatory cytokines (minor allele frequency, 45.6%; P < 1.0 * 10(-323)). This association was supported by family-based genetic linkage at a locus encompassing the DARC gene (genome-wide P = 8.0 * 10(-13)). Asp42Gly accounted for approximately 20% of the variability in serum MCP-1 concentrations and also was associated with serum concentrations of interleukin-8 and RANTES. While exploring a lack of association between this polymorphism and EDTA plasma MCP-1 concentrations (P = .82), we determined that both clotting and exogenous heparan sulfate (unfractionated heparin) released substantial amounts of MCP-1 from Darc. Quantitative immunoflow cytometry failed to identify meaningful Asp42Gly-associated differences in Darc expression, suggesting that a functional change is responsible for the differential cytokine binding. We conclude that Asp42Gly is a major regulator of erythrocyte Darc-mediated cytokine binding and thereby the circulating concentrations of several proinflammatory cytokines. We have also identified for the first time 2 mechanisms for the release of reservoir chemokines with possible clinical implications. |
| Author | Vasan, Ramachandran S. Ballantyne, Christie M. Psaty, Bruce M. Schnabel, Renate B. Heiss, Gerardo Illig, Thomas Baumert, Jens Boerwinkle, Eric Zhu, Yanyan Witteman, Jacqueline C.M. Dehghan, Abbas Gieger, Christian Benjamin, Emelia J. Durda, Peter Tilley, Cathy Khuseyinova, Natalie Yamamoto, Jennifer F. Morrison, Alanna C. Larson, Martin G. Bis, Joshua C. Hoogeveen, Ron C. Koenig, Wolfgang Peters, Annette Tracy, Russell P. Jenny, Nancy S. Keaney, John F. Blankenberg, Stefan Doyle, Margaret Walston, Jeremy D. Ellinor, Patrick T. Barbalic, Maja Dupuis, Josée Klopp, Norman Herder, Christian |
| Author_xml | – sequence: 1 givenname: Renate B. surname: Schnabel fullname: Schnabel, Renate B. organization: National Heart, Lung, and Blood Institute and Boston University Framingham Heart Study, MA – sequence: 2 givenname: Jens surname: Baumert fullname: Baumert, Jens organization: Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany – sequence: 3 givenname: Maja surname: Barbalic fullname: Barbalic, Maja organization: Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center at Houston – sequence: 4 givenname: Josée surname: Dupuis fullname: Dupuis, Josée organization: National Heart, Lung, and Blood Institute and Boston University Framingham Heart Study, MA – sequence: 5 givenname: Patrick T. surname: Ellinor fullname: Ellinor, Patrick T. organization: Cardiovascular Research Center, Massachusetts General Hospital, Boston – sequence: 6 givenname: Peter surname: Durda fullname: Durda, Peter organization: Department of Pathology, University of Vermont College of Medicine, Burlington – sequence: 7 givenname: Abbas surname: Dehghan fullname: Dehghan, Abbas organization: Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands – sequence: 8 givenname: Joshua C. surname: Bis fullname: Bis, Joshua C. organization: Department of Medicine, University of Washington, Seattle – sequence: 9 givenname: Thomas surname: Illig fullname: Illig, Thomas organization: Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany – sequence: 10 givenname: Alanna C. surname: Morrison fullname: Morrison, Alanna C. organization: Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center at Houston – sequence: 11 givenname: Nancy S. surname: Jenny fullname: Jenny, Nancy S. organization: Department of Pathology, University of Vermont College of Medicine, Burlington – sequence: 12 givenname: John F. surname: Keaney fullname: Keaney, John F. organization: National Heart, Lung, and Blood Institute and Boston University Framingham Heart Study, MA – sequence: 13 givenname: Christian surname: Gieger fullname: Gieger, Christian organization: Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany – sequence: 14 givenname: Cathy surname: Tilley fullname: Tilley, Cathy organization: Department of Pathology, University of Vermont College of Medicine, Burlington – sequence: 15 givenname: Jennifer F. surname: Yamamoto fullname: Yamamoto, Jennifer F. organization: National Heart, Lung, and Blood Institute and Boston University Framingham Heart Study, MA – sequence: 16 givenname: Natalie surname: Khuseyinova fullname: Khuseyinova, Natalie organization: Department of Internal Medicine II–Cardiology, University of Ulm Medical Center, Ulm, Germany – sequence: 17 givenname: Gerardo surname: Heiss fullname: Heiss, Gerardo organization: Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center at Houston – sequence: 18 givenname: Margaret surname: Doyle fullname: Doyle, Margaret organization: Department of Pathology, University of Vermont College of Medicine, Burlington – sequence: 19 givenname: Stefan surname: Blankenberg fullname: Blankenberg, Stefan organization: Gutenberg Heart Study, Johannes Gutenberg-University, Mainz, Germany – sequence: 20 givenname: Christian surname: Herder fullname: Herder, Christian organization: Institute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Duesseldorf, Germany – sequence: 21 givenname: Jeremy D. surname: Walston fullname: Walston, Jeremy D. organization: Department of Medicine and Johns Hopkins Geriatrics Center, Johns Hopkins University, Baltimore, MD – sequence: 22 givenname: Yanyan surname: Zhu fullname: Zhu, Yanyan organization: Department of Biostatistics, Boston University School of Public Health, MA – sequence: 23 givenname: Ramachandran S. surname: Vasan fullname: Vasan, Ramachandran S. organization: National Heart, Lung, and Blood Institute and Boston University Framingham Heart Study, MA – sequence: 24 givenname: Norman surname: Klopp fullname: Klopp, Norman organization: Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany – sequence: 25 givenname: Eric surname: Boerwinkle fullname: Boerwinkle, Eric organization: Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center at Houston – sequence: 26 givenname: Martin G. surname: Larson fullname: Larson, Martin G. organization: National Heart, Lung, and Blood Institute and Boston University Framingham Heart Study, MA – sequence: 27 givenname: Bruce M. surname: Psaty fullname: Psaty, Bruce M. organization: Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington and Center for Health Studies, Group Health, Seattle – sequence: 28 givenname: Annette surname: Peters fullname: Peters, Annette organization: Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany – sequence: 29 givenname: Christie M. surname: Ballantyne fullname: Ballantyne, Christie M. organization: Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center at Houston – sequence: 30 givenname: Jacqueline C.M. surname: Witteman fullname: Witteman, Jacqueline C.M. organization: Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands – sequence: 31 givenname: Ron C. surname: Hoogeveen fullname: Hoogeveen, Ron C. email: emelia@bu.edu, ronh@bcm.tmc.edu, wolfgang.koenig@uniklinik-ulm.de, russell.tracy@uvm.edu organization: Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center at Houston – sequence: 32 givenname: Emelia J. surname: Benjamin fullname: Benjamin, Emelia J. organization: National Heart, Lung, and Blood Institute and Boston University Framingham Heart Study, MA – sequence: 33 givenname: Wolfgang surname: Koenig fullname: Koenig, Wolfgang organization: Department of Internal Medicine II–Cardiology, University of Ulm Medical Center, Ulm, Germany – sequence: 34 givenname: Russell P. surname: Tracy fullname: Tracy, Russell P. organization: Department of Pathology, University of Vermont College of Medicine, Burlington |
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| Cites_doi | 10.1182/blood.V86.10.3841.bloodjournal86103841 10.1378/chest.124.3_suppl.49S 10.1038/sj.gene.6364434 10.1038/29788 10.1124/mol.107.040915 10.1038/35006097 10.1038/nm1444 10.1093/oxfordjournals.aje.a115184 10.1055/s-2005-858226 10.1042/BST0341005 10.1046/j.1523-1755.2000.00316.x 10.1055/s-0037-1613858 10.1002/art.20266 10.1016/S0021-9258(18)31379-6 10.1161/ATVBAHA.108.169417 10.1161/hq0701.093686 10.1073/pnas.0707138105 10.1371/journal.pgen.1000360 10.1016/j.atherosclerosis.2005.02.015 10.1016/j.cytogfr.2005.05.011 10.1182/blood.V85.3.622.bloodjournal853622 10.1073/pnas.91.7.2752 10.1161/CIRCULATIONAHA.105.543579 10.1074/jbc.M601284200 10.1111/j.1744-313X.2007.00734.x 10.1097/01.TP.0000061228.38243.26 10.1161/01.ATV.0000038486.48400.E7 10.1016/j.cca.2007.03.017 10.1016/S0006-291X(03)00293-6 10.1111/j.1365-2958.2004.04478.x 10.1038/ng2088 10.1038/ng1847 10.1182/blood.V96.5.1681 10.1371/journal.pgen.0010054 10.1096/fj.05-4764com 10.1182/blood.V96.1.34.013a49_34_40 10.1016/j.jacc.2007.06.057 10.1182/blood-2007-10-118497 10.1182/blood-2007-08-108316 10.1093/oxfordjournals.aje.a112813 10.1016/j.cca.2005.12.014 10.1016/j.biocel.2008.07.018 10.1101/gr.6009507 10.1172/JCI29919 10.1259/bjr/88469693 |
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| Copyright | 2010 American Society of Hematology 2015 INIST-CNRS 2010 by The American Society of Hematology |
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| Keywords | Antigen Chemokine Blood group Genetic variability Hematology Genotype Duffy system Inflammation Chemokine receptor Monocyte chemoattractant protein 1 Polymorphism |
| Language | English |
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| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 A.D. and J.C.M.W. are members of The Netherlands Consortium on Healthy Aging (NCHA). R.B.S., J.B., M.B., J.D., P.T.E., R.C.H., E.J.B., W.K., and R.P.T. contributed equally to this study. |
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| Publisher | Elsevier Inc Americain Society of Hematology American Society of Hematology |
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| References | McDermott, Yang, Kathiresan (bib13) 2005; 112 Shen, Schuster, Stringer, Waltz, Lentsch (bib38) 2006; 20 Tucci, Barnes, Sobel (bib10) 2004; 50 Ohta, Kitadai, Tanaka (bib9) 2003; 22 Cardona, Sasse, Liu (bib43) 2008; 112 Price, Patterson, Plenge, Weinblatt, Shadick, Reich (bib24) 2006; 38 Tracy (bib1) 2003; 124 Neote, Darbonne, Ogez, Horuk, Schall (bib5) 1993; 268 Wang, Yang, Gao, Gao, Li, Liu (bib16) 2008; 35 Segerer, Regele, Mack (bib39) 2000; 58 Bossink, Paemen, Jansen, Hack, Thijs, Van (bib8) 1995; 86 Tsou, Peters, Si (bib42) 2007; 117 Bonecchi, Borroni, Anselmo (bib44) 2008; 112 Bandyopadhyay, Zhan, Chaudhuri (bib37) 2006; 12 Wichmann, Gieger, Illig (bib20) 2005; 6 Rot (bib27) 2005; 16 Marchini, Howie, Myers, McVean, Donnelly (bib21) 2007; 39 Joven, Coll, Tous (bib17) 2006; 368 Choe, Moore, Owens (bib36) 2005; 55 Dawson, Lentsch, Wang (bib32) 2000; 96 Gleissner, von, Ley (bib2) 2008; 28 Reich, Nalls, Kao (bib30) 2009; 5 Edderkaoui, Baylink, Beamer (bib34) 2007; 17 de Lemos, Morrow, Blazing (bib40) 2007; 50 Salcedo, Ponce, Young (bib6) 2000; 96 Valdes, Wolfe, O'Brien (bib45) 2002; 22 Fukuma, Akimitsu, Hamamoto, Kusuhara, Sugiyama, Sekimizu (bib33) 2003; 303 Gu, Tseng, Horner, Tam, Loda, Rollins (bib7) 2000; 404 Kamei, Tobe, Suzuki (bib11) 2006; 281 Chakera, Seeber, John, Eidne, Greaves (bib28) 2008; 73 Akalin, Neylan (bib31) 2003; 75 Dupuis, Larson, Vasan (bib15) 2005; 182 Bielinski, Pankow, Miller (bib14) 2007; 8 McVean, Spencer, Chaix (bib35) 2005; 1 van Aken, den, Bos, van Deventer, Reitsma (bib41) 2000; 83 Boring, Gosling, Cleary, Charo (bib12) 1998; 394 (bib18) 1989; 129 Dupuis, Siegmund, Yakir (bib23) 2007; 104 Pruenster, Rot (bib29) 2006; 34 Cha, Lee, Lee (bib46) 2007; 382 Hirsh, Anand, Halperin, Fuster (bib25) 2001; 21 Melgarejo, Medina, Sanchez-Jimenez, Urdiales (bib3) 2009; 41 Kannel, Feinleib, McNamara, Garrison, Castelli (bib19) 1979; 110 Iwamoto, Omi, Kajii, Ikemoto (bib26) 1995; 85 Charo, Myers, Herman, Franci, Connolly, Coughlin (bib4) 1994; 91 Li, Wong, Wong, Lee, Au Yeung (bib22) 2006; 79 20595521 - Blood. 2010 Jul 1;115(26):5285-6 de Lemos (2019111815483296500_B40) 2007; 50 Shen (2019111815483296500_B38) 2006; 20 Tucci (2019111815483296500_B10) 2004; 50 McDermott (2019111815483296500_B13) 2005; 112 Reich (2019111815483296500_B30) 2009; 5 Marchini (2019111815483296500_B21) 2007; 39 Charo (2019111815483296500_B4) 1994; 91 Cha (2019111815483296500_B46) 2007; 382 Tracy (2019111815483296500_B1) 2003; 124 Kannel (2019111815483296500_B19) 1979; 110 Ohta (2019111815483296500_B9) 2003; 22 Rot (2019111815483296500_B27) 2005; 16 Gu (2019111815483296500_B7) 2000; 404 Bandyopadhyay (2019111815483296500_B37) 2006; 12 (2019111815483296500_B18) 1989; 129 Pruenster (2019111815483296500_B29) 2006; 34 Price (2019111815483296500_B24) 2006; 38 Bonecchi (2019111815483296500_B44) 2008; 112 Boring (2019111815483296500_B12) 1998; 394 Tsou (2019111815483296500_B42) 2007; 117 Li (2019111815483296500_B22) 2006; 79 Akalin (2019111815483296500_B31) 2003; 75 Cardona (2019111815483296500_B43) 2008; 112 Dupuis (2019111815483296500_B23) 2007; 104 Wang (2019111815483296500_B16) 2008; 35 Melgarejo (2019111815483296500_B3) 2009; 41 Valdes (2019111815483296500_B45) 2002; 22 Wichmann (2019111815483296500_B20) 2005; 6 Dawson (2019111815483296500_B32) 2000; 96 Kamei (2019111815483296500_B11) 2006; 281 Joven (2019111815483296500_B17) 2006; 368 Dupuis (2019111815483296500_B15) 2005; 182 McVean (2019111815483296500_B35) 2005; 1 Choe (2019111815483296500_B36) 2005; 55 Bielinski (2019111815483296500_B14) 2007; 8 Neote (2019111815483296500_B5) 1993; 268 Fukuma (2019111815483296500_B33) 2003; 303 Iwamoto (2019111815483296500_B26) 1995; 85 Chakera (2019111815483296500_B28) 2008; 73 Segerer (2019111815483296500_B39) 2000; 58 van Aken (2019111815483296500_B41) 2000; 83 Hirsh (2019111815483296500_B25) 2001; 21 Gleissner (2019111815483296500_B2) 2008; 28 Bossink (2019111815483296500_B8) 1995; 86 Salcedo (2019111815483296500_B6) 2000; 96 Edderkaoui (2019111815483296500_B34) 2007; 17 |
| References_xml | – volume: 38 start-page: 904 year: 2006 end-page: 909 ident: bib24 article-title: Principal components analysis corrects for stratification in genome-wide association studies publication-title: Nat Genet contributor: fullname: Reich – volume: 73 start-page: 1362 year: 2008 end-page: 1370 ident: bib28 article-title: The duffy antigen/receptor for chemokines exists in an oligomeric form in living cells and functionally antagonizes CCR5 signaling through hetero-oligomerization publication-title: Mol Pharmacol contributor: fullname: Greaves – volume: 34 start-page: 1005 year: 2006 end-page: 1008 ident: bib29 article-title: Throwing light on DARC publication-title: Biochem Soc Trans contributor: fullname: Rot – volume: 17 start-page: 577 year: 2007 end-page: 585 ident: bib34 article-title: Identification of mouse Duffy antigen receptor for chemokines (Darc) as a BMD QTL gene publication-title: Genome Res contributor: fullname: Beamer – volume: 368 start-page: 114 year: 2006 end-page: 119 ident: bib17 article-title: The influence of HIV infection on the correlation between plasma concentrations of monocyte chemoattractant protein-1 and carotid atherosclerosis publication-title: Clin Chim Acta contributor: fullname: Tous – volume: 75 start-page: 1496 year: 2003 end-page: 1500 ident: bib31 article-title: The influence of Duffy blood group on renal allograft outcome in African Americans publication-title: Transplantation contributor: fullname: Neylan – volume: 12 start-page: 933 year: 2006 end-page: 938 ident: bib37 article-title: Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression publication-title: Nat Med contributor: fullname: Chaudhuri – volume: 96 start-page: 1681 year: 2000 end-page: 1684 ident: bib32 article-title: Exaggerated response to endotoxin in mice lacking the Duffy antigen/receptor for chemokines (DARC) publication-title: Blood contributor: fullname: Wang – volume: 85 start-page: 622 year: 1995 end-page: 626 ident: bib26 article-title: Genomic organization of the glycoprotein D gene: Duffy blood group Fya/Fyb alloantigen system is associated with a polymorphism at the 44-amino acid residue publication-title: Blood contributor: fullname: Ikemoto – volume: 124 start-page: 49S year: 2003 end-page: 57S ident: bib1 article-title: Thrombin, inflammation, and cardiovascular disease: an epidemiologic perspective publication-title: Chest contributor: fullname: Tracy – volume: 96 start-page: 34 year: 2000 end-page: 40 ident: bib6 article-title: Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression publication-title: Blood contributor: fullname: Young – volume: 91 start-page: 2752 year: 1994 end-page: 2756 ident: bib4 article-title: Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails publication-title: Proc Natl Acad Sci U S A contributor: fullname: Coughlin – volume: 55 start-page: 1413 year: 2005 end-page: 1422 ident: bib36 article-title: Sulphated tyrosines mediate association of chemokines and Plasmodium vivax Duffy binding protein with the Duffy antigen/receptor for chemokines (DARC) publication-title: Mol Microbiol contributor: fullname: Owens – volume: 268 start-page: 12247 year: 1993 end-page: 12249 ident: bib5 article-title: Identification of a promiscuous inflammatory peptide receptor on the surface of red blood cells publication-title: J Biol Chem contributor: fullname: Schall – volume: 8 start-page: 684 year: 2007 end-page: 690 ident: bib14 article-title: Circulating MCP-1 levels shows linkage to chemokine receptor gene cluster on chromosome 3: the NHLBI family heart study follow-up examination publication-title: Genes Immun contributor: fullname: Miller – volume: 110 start-page: 281 year: 1979 end-page: 290 ident: bib19 article-title: An investigation of coronary heart disease in families. The Framingham offspring study publication-title: Am J Epidemiol contributor: fullname: Castelli – volume: 382 start-page: 129 year: 2007 end-page: 133 ident: bib46 article-title: Association of CCR2 polymorphisms with the number of closed coronary artery vessels in coronary artery disease publication-title: Clin Chim Acta contributor: fullname: Lee – volume: 39 start-page: 906 year: 2007 end-page: 913 ident: bib21 article-title: A new multipoint method for genome-wide association studies by imputation of genotypes publication-title: Nat Genet contributor: fullname: Donnelly – volume: 50 start-page: 2117 year: 2007 end-page: 2124 ident: bib40 article-title: Serial measurement of monocyte chemoattractant protein-1 after acute coronary syndromes: results from the A to Z trial publication-title: J Am Coll Cardiol contributor: fullname: Blazing – volume: 50 start-page: 1842 year: 2004 end-page: 1849 ident: bib10 article-title: Strong association of a functional polymorphism in the monocyte chemoattractant protein 1 promoter gene with lupus nephritis publication-title: Arthritis Rheum contributor: fullname: Sobel – volume: 1 start-page: e54 year: 2005 ident: bib35 article-title: Perspectives on human genetic variation from the HapMap Project publication-title: PLoS Genet contributor: fullname: Chaix – volume: 112 start-page: 493 year: 2008 end-page: 503 ident: bib44 article-title: Regulation of D6 chemokine scavenging activity by ligand- and Rab11-dependent surface up-regulation publication-title: Blood contributor: fullname: Anselmo – volume: 303 start-page: 137 year: 2003 end-page: 139 ident: bib33 article-title: A role of the Duffy antigen for the maintenance of plasma chemokine concentrations publication-title: Biochem Biophys Res Commun contributor: fullname: Sekimizu – volume: 5 start-page: e1000360 year: 2009 ident: bib30 article-title: Reduced neutrophil count in people of African descent is due to a regulatory variant in the duffy antigen receptor for chemokines gene publication-title: PLoS Genet contributor: fullname: Kao – volume: 104 start-page: 20210 year: 2007 end-page: 20215 ident: bib23 article-title: A unified framework for linkage and association analysis of quantitative traits publication-title: Proc Natl Acad Sci U S A contributor: fullname: Yakir – volume: 112 start-page: 256 year: 2008 end-page: 263 ident: bib43 article-title: Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues publication-title: Blood contributor: fullname: Liu – volume: 404 start-page: 407 year: 2000 end-page: 411 ident: bib7 article-title: Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1 publication-title: Nature contributor: fullname: Rollins – volume: 117 start-page: 902 year: 2007 end-page: 909 ident: bib42 article-title: Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites publication-title: J Clin Invest contributor: fullname: Si – volume: 28 start-page: 1920 year: 2008 end-page: 1927 ident: bib2 article-title: Platelet chemokines in vascular disease publication-title: Arterioscler Thromb Vasc Biol contributor: fullname: Ley – volume: 83 start-page: 536 year: 2000 end-page: 539 ident: bib41 article-title: Recurrent venous thrombosis and markers of inflammation publication-title: Thromb Haemost contributor: fullname: Reitsma – volume: 182 start-page: 307 year: 2005 end-page: 314 ident: bib15 article-title: Genome scan of systemic biomarkers of vascular inflammation in the Framingham Heart Study: evidence for susceptibility loci on 1q publication-title: Atherosclerosis contributor: fullname: Vasan – volume: 6 start-page: S26 year: 2005 end-page: S30 ident: bib20 article-title: KORA-gen: resource for population genetics, controls and a broad spectrum of disease phenotypes publication-title: Gesundheitswesen contributor: fullname: Illig – volume: 86 start-page: 3841 year: 1995 end-page: 3847 ident: bib8 article-title: Plasma levels of the chemokines monocyte chemotactic proteins-1 and -2 are elevated in human sepsis publication-title: Blood contributor: fullname: Van – volume: 281 start-page: 26602 year: 2006 end-page: 26614 ident: bib11 article-title: Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance publication-title: J Biol Chem contributor: fullname: Suzuki – volume: 35 start-page: 45 year: 2008 end-page: 49 ident: bib16 article-title: A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with psoriasis publication-title: Int J Immunogenet contributor: fullname: Liu – volume: 22 start-page: 773 year: 2003 end-page: 778 ident: bib9 article-title: Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human gastric carcinomas publication-title: Int J Oncol contributor: fullname: Tanaka – volume: 16 start-page: 687 year: 2005 end-page: 694 ident: bib27 article-title: Contribution of Duffy antigen to chemokine function publication-title: Cytokine Growth Factor Rev contributor: fullname: Rot – volume: 79 start-page: 368 year: 2006 end-page: 371 ident: bib22 article-title: Acute adverse reactions to magnetic resonance contrast media–gadolinium chelates publication-title: Br J Radiol contributor: fullname: Au Yeung – volume: 22 start-page: 1924 year: 2002 end-page: 1928 ident: bib45 article-title: Val64Ile polymorphism in the C-C chemokine receptor 2 is associated with reduced coronary artery calcification publication-title: Arterioscler Thromb Vasc Biol contributor: fullname: O'Brien – volume: 112 start-page: 1113 year: 2005 end-page: 1120 ident: bib13 article-title: CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart Study publication-title: Circulation contributor: fullname: Kathiresan – volume: 20 start-page: 59 year: 2006 end-page: 64 ident: bib38 article-title: The Duffy antigen/receptor for chemokines (DARC) regulates prostate tumor growth publication-title: FASEB J contributor: fullname: Lentsch – volume: 58 start-page: 1546 year: 2000 end-page: 1556 ident: bib39 article-title: The Duffy antigen receptor for chemokines is up-regulated during acute renal transplant rejection and crescentic glomerulonephritis publication-title: Kidney Int contributor: fullname: Mack – volume: 394 start-page: 894 year: 1998 end-page: 897 ident: bib12 article-title: Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis publication-title: Nature contributor: fullname: Charo – volume: 41 start-page: 998 year: 2009 end-page: 1001 ident: bib3 article-title: Monocyte chemoattractant protein-1: a key mediator in inflammatory processes publication-title: Int J Biochem Cell Biol contributor: fullname: Urdiales – volume: 129 start-page: 687 year: 1989 end-page: 702 ident: bib18 article-title: The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. The ARIC investigators publication-title: Am J Epidemiol – volume: 21 start-page: 1094 year: 2001 end-page: 1096 ident: bib25 article-title: Mechanism of action and pharmacology of unfractionated heparin publication-title: Arterioscler Thromb Vasc Biol contributor: fullname: Fuster – volume: 86 start-page: 3841 issue: 10 year: 1995 ident: 2019111815483296500_B8 article-title: Plasma levels of the chemokines monocyte chemotactic proteins-1 and -2 are elevated in human sepsis. publication-title: Blood doi: 10.1182/blood.V86.10.3841.bloodjournal86103841 contributor: fullname: Bossink – volume: 124 start-page: 49S year: 2003 ident: 2019111815483296500_B1 article-title: Thrombin, inflammation, and cardiovascular disease: an epidemiologic perspective. publication-title: Chest doi: 10.1378/chest.124.3_suppl.49S contributor: fullname: Tracy – volume: 8 start-page: 684 issue: 8 year: 2007 ident: 2019111815483296500_B14 article-title: Circulating MCP-1 levels shows linkage to chemokine receptor gene cluster on chromosome 3: the NHLBI family heart study follow-up examination. publication-title: Genes Immun doi: 10.1038/sj.gene.6364434 contributor: fullname: Bielinski – volume: 394 start-page: 894 issue: 6696 year: 1998 ident: 2019111815483296500_B12 article-title: Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis. publication-title: Nature doi: 10.1038/29788 contributor: fullname: Boring – volume: 73 start-page: 1362 issue: 5 year: 2008 ident: 2019111815483296500_B28 article-title: The duffy antigen/receptor for chemokines exists in an oligomeric form in living cells and functionally antagonizes CCR5 signaling through hetero-oligomerization. publication-title: Mol Pharmacol doi: 10.1124/mol.107.040915 contributor: fullname: Chakera – volume: 404 start-page: 407 issue: 6776 year: 2000 ident: 2019111815483296500_B7 article-title: Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1. publication-title: Nature doi: 10.1038/35006097 contributor: fullname: Gu – volume: 12 start-page: 933 issue: 8 year: 2006 ident: 2019111815483296500_B37 article-title: Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression. publication-title: Nat Med doi: 10.1038/nm1444 contributor: fullname: Bandyopadhyay – volume: 129 start-page: 687 issue: 4 year: 1989 ident: 2019111815483296500_B18 article-title: The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. The ARIC investigators. publication-title: Am J Epidemiol doi: 10.1093/oxfordjournals.aje.a115184 – volume: 6 start-page: S26 year: 2005 ident: 2019111815483296500_B20 article-title: KORA-gen: resource for population genetics, controls and a broad spectrum of disease phenotypes. publication-title: Gesundheitswesen doi: 10.1055/s-2005-858226 contributor: fullname: Wichmann – volume: 34 start-page: 1005 issue: Pt 6 year: 2006 ident: 2019111815483296500_B29 article-title: Throwing light on DARC. publication-title: Biochem Soc Trans doi: 10.1042/BST0341005 contributor: fullname: Pruenster – volume: 58 start-page: 1546 issue: 4 year: 2000 ident: 2019111815483296500_B39 article-title: The Duffy antigen receptor for chemokines is up-regulated during acute renal transplant rejection and crescentic glomerulonephritis. publication-title: Kidney Int doi: 10.1046/j.1523-1755.2000.00316.x contributor: fullname: Segerer – volume: 83 start-page: 536 issue: 4 year: 2000 ident: 2019111815483296500_B41 article-title: Recurrent venous thrombosis and markers of inflammation. publication-title: Thromb Haemost doi: 10.1055/s-0037-1613858 contributor: fullname: van Aken – volume: 50 start-page: 1842 issue: 6 year: 2004 ident: 2019111815483296500_B10 article-title: Strong association of a functional polymorphism in the monocyte chemoattractant protein 1 promoter gene with lupus nephritis. publication-title: Arthritis Rheum doi: 10.1002/art.20266 contributor: fullname: Tucci – volume: 268 start-page: 12247 issue: 17 year: 1993 ident: 2019111815483296500_B5 article-title: Identification of a promiscuous inflammatory peptide receptor on the surface of red blood cells. publication-title: J Biol Chem doi: 10.1016/S0021-9258(18)31379-6 contributor: fullname: Neote – volume: 28 start-page: 1920 issue: 11 year: 2008 ident: 2019111815483296500_B2 article-title: Platelet chemokines in vascular disease. publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.108.169417 contributor: fullname: Gleissner – volume: 21 start-page: 1094 issue: 7 year: 2001 ident: 2019111815483296500_B25 article-title: Mechanism of action and pharmacology of unfractionated heparin. publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/hq0701.093686 contributor: fullname: Hirsh – volume: 104 start-page: 20210 issue: 51 year: 2007 ident: 2019111815483296500_B23 article-title: A unified framework for linkage and association analysis of quantitative traits. publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0707138105 contributor: fullname: Dupuis – volume: 5 start-page: e1000360 issue: 1 year: 2009 ident: 2019111815483296500_B30 article-title: Reduced neutrophil count in people of African descent is due to a regulatory variant in the duffy antigen receptor for chemokines gene. publication-title: PLoS Genet doi: 10.1371/journal.pgen.1000360 contributor: fullname: Reich – volume: 182 start-page: 307 issue: 2 year: 2005 ident: 2019111815483296500_B15 article-title: Genome scan of systemic biomarkers of vascular inflammation in the Framingham Heart Study: evidence for susceptibility loci on 1q. publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2005.02.015 contributor: fullname: Dupuis – volume: 16 start-page: 687 issue: 6 year: 2005 ident: 2019111815483296500_B27 article-title: Contribution of Duffy antigen to chemokine function. publication-title: Cytokine Growth Factor Rev doi: 10.1016/j.cytogfr.2005.05.011 contributor: fullname: Rot – volume: 85 start-page: 622 issue: 3 year: 1995 ident: 2019111815483296500_B26 article-title: Genomic organization of the glycoprotein D gene: Duffy blood group Fya/Fyb alloantigen system is associated with a polymorphism at the 44-amino acid residue. publication-title: Blood doi: 10.1182/blood.V85.3.622.bloodjournal853622 contributor: fullname: Iwamoto – volume: 91 start-page: 2752 issue: 7 year: 1994 ident: 2019111815483296500_B4 article-title: Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.91.7.2752 contributor: fullname: Charo – volume: 112 start-page: 1113 issue: 8 year: 2005 ident: 2019111815483296500_B13 article-title: CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart Study. publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.105.543579 contributor: fullname: McDermott – volume: 281 start-page: 26602 issue: 36 year: 2006 ident: 2019111815483296500_B11 article-title: Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. publication-title: J Biol Chem doi: 10.1074/jbc.M601284200 contributor: fullname: Kamei – volume: 35 start-page: 45 issue: 1 year: 2008 ident: 2019111815483296500_B16 article-title: A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with psoriasis. publication-title: Int J Immunogenet doi: 10.1111/j.1744-313X.2007.00734.x contributor: fullname: Wang – volume: 75 start-page: 1496 issue: 9 year: 2003 ident: 2019111815483296500_B31 article-title: The influence of Duffy blood group on renal allograft outcome in African Americans. publication-title: Transplantation doi: 10.1097/01.TP.0000061228.38243.26 contributor: fullname: Akalin – volume: 22 start-page: 1924 issue: 11 year: 2002 ident: 2019111815483296500_B45 article-title: Val64Ile polymorphism in the C-C chemokine receptor 2 is associated with reduced coronary artery calcification. publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/01.ATV.0000038486.48400.E7 contributor: fullname: Valdes – volume: 382 start-page: 129 issue: 1–2 year: 2007 ident: 2019111815483296500_B46 article-title: Association of CCR2 polymorphisms with the number of closed coronary artery vessels in coronary artery disease. publication-title: Clin Chim Acta doi: 10.1016/j.cca.2007.03.017 contributor: fullname: Cha – volume: 303 start-page: 137 issue: 1 year: 2003 ident: 2019111815483296500_B33 article-title: A role of the Duffy antigen for the maintenance of plasma chemokine concentrations. publication-title: Biochem Biophys Res Commun doi: 10.1016/S0006-291X(03)00293-6 contributor: fullname: Fukuma – volume: 55 start-page: 1413 issue: 5 year: 2005 ident: 2019111815483296500_B36 article-title: Sulphated tyrosines mediate association of chemokines and Plasmodium vivax Duffy binding protein with the Duffy antigen/receptor for chemokines (DARC). publication-title: Mol Microbiol doi: 10.1111/j.1365-2958.2004.04478.x contributor: fullname: Choe – volume: 39 start-page: 906 issue: 7 year: 2007 ident: 2019111815483296500_B21 article-title: A new multipoint method for genome-wide association studies by imputation of genotypes. publication-title: Nat Genet doi: 10.1038/ng2088 contributor: fullname: Marchini – volume: 22 start-page: 773 issue: 4 year: 2003 ident: 2019111815483296500_B9 article-title: Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human gastric carcinomas. publication-title: Int J Oncol contributor: fullname: Ohta – volume: 38 start-page: 904 issue: 8 year: 2006 ident: 2019111815483296500_B24 article-title: Principal components analysis corrects for stratification in genome-wide association studies. publication-title: Nat Genet doi: 10.1038/ng1847 contributor: fullname: Price – volume: 96 start-page: 1681 issue: 5 year: 2000 ident: 2019111815483296500_B32 article-title: Exaggerated response to endotoxin in mice lacking the Duffy antigen/receptor for chemokines (DARC). publication-title: Blood doi: 10.1182/blood.V96.5.1681 contributor: fullname: Dawson – volume: 1 start-page: e54 issue: 4 year: 2005 ident: 2019111815483296500_B35 article-title: Perspectives on human genetic variation from the HapMap Project. publication-title: PLoS Genet doi: 10.1371/journal.pgen.0010054 contributor: fullname: McVean – volume: 20 start-page: 59 issue: 1 year: 2006 ident: 2019111815483296500_B38 article-title: The Duffy antigen/receptor for chemokines (DARC) regulates prostate tumor growth. publication-title: FASEB J doi: 10.1096/fj.05-4764com contributor: fullname: Shen – volume: 96 start-page: 34 issue: 1 year: 2000 ident: 2019111815483296500_B6 article-title: Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression. publication-title: Blood doi: 10.1182/blood.V96.1.34.013a49_34_40 contributor: fullname: Salcedo – volume: 50 start-page: 2117 issue: 22 year: 2007 ident: 2019111815483296500_B40 article-title: Serial measurement of monocyte chemoattractant protein-1 after acute coronary syndromes: results from the A to Z trial. publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2007.06.057 contributor: fullname: de Lemos – volume: 112 start-page: 256 issue: 2 year: 2008 ident: 2019111815483296500_B43 article-title: Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues. publication-title: Blood doi: 10.1182/blood-2007-10-118497 contributor: fullname: Cardona – volume: 112 start-page: 493 issue: 3 year: 2008 ident: 2019111815483296500_B44 article-title: Regulation of D6 chemokine scavenging activity by ligand- and Rab11-dependent surface up-regulation. publication-title: Blood doi: 10.1182/blood-2007-08-108316 contributor: fullname: Bonecchi – volume: 110 start-page: 281 issue: 3 year: 1979 ident: 2019111815483296500_B19 article-title: An investigation of coronary heart disease in families. The Framingham offspring study. publication-title: Am J Epidemiol doi: 10.1093/oxfordjournals.aje.a112813 contributor: fullname: Kannel – volume: 368 start-page: 114 issue: 1–2 year: 2006 ident: 2019111815483296500_B17 article-title: The influence of HIV infection on the correlation between plasma concentrations of monocyte chemoattractant protein-1 and carotid atherosclerosis. publication-title: Clin Chim Acta doi: 10.1016/j.cca.2005.12.014 contributor: fullname: Joven – volume: 41 start-page: 998 issue: 5 year: 2009 ident: 2019111815483296500_B3 article-title: Monocyte chemoattractant protein-1: a key mediator in inflammatory processes. publication-title: Int J Biochem Cell Biol doi: 10.1016/j.biocel.2008.07.018 contributor: fullname: Melgarejo – volume: 17 start-page: 577 issue: 5 year: 2007 ident: 2019111815483296500_B34 article-title: Identification of mouse Duffy antigen receptor for chemokines (Darc) as a BMD QTL gene. publication-title: Genome Res doi: 10.1101/gr.6009507 contributor: fullname: Edderkaoui – volume: 117 start-page: 902 issue: 4 year: 2007 ident: 2019111815483296500_B42 article-title: Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites. publication-title: J Clin Invest doi: 10.1172/JCI29919 contributor: fullname: Tsou – volume: 79 start-page: 368 issue: 941 year: 2006 ident: 2019111815483296500_B22 article-title: Acute adverse reactions to magnetic resonance contrast media–gadolinium chelates. publication-title: Br J Radiol doi: 10.1259/bjr/88469693 contributor: fullname: Li |
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| Snippet | To identify the genetic basis of circulating concentrations of monocyte chemoattractant protein-1 (MCP-1), we conducted genome-wide association analyses for... |
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| SubjectTerms | Adult Biological and medical sciences Chemokine CCL2 - blood Chemokine CCL2 - genetics Chromosomes, Human, Pair 1 Cohort Studies Duffy Blood-Group System - genetics Duffy Blood-Group System - metabolism Erythrocytes - metabolism Female Genetic Loci Genome-Wide Association Study Hematologic and hematopoietic diseases Humans Inflammation Mediators - blood Male Medical sciences Middle Aged Plenary Paper Polymorphism, Single Nucleotide Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism |
| Title | Duffy antigen receptor for chemokines (Darc) polymorphism regulates circulating concentrations of monocyte chemoattractant protein-1 and other inflammatory mediators |
| URI | https://dx.doi.org/10.1182/blood-2009-05-221382 https://www.ncbi.nlm.nih.gov/pubmed/20040767 https://search.proquest.com/docview/733627774 https://pubmed.ncbi.nlm.nih.gov/PMC2902130 |
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