Structure-Based Design of Potent Small-Molecule Binders to the S-Component of the ECF Transporter for Thiamine

Energy‐coupling factor (ECF) transporters are membrane‐protein complexes that mediate vitamin uptake in prokaryotes. They bind the substrate through the action of a specific integral membrane subunit (S‐component) and power transport by hydrolysis of ATP in the three‐subunit ECF module. Here, we hav...

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Bibliographic Details
Published in:	Chembiochem : a European journal of chemical biology Vol. 16; no. 5; pp. 819 - 826
Main Authors:	Swier, Lotteke J. Y. M., Monjas, Leticia, Guskov, Albert, de Voogd, Alrik R., Erkens, Guus B., Slotboom, Dirk J., Hirsch, Anna K. H.
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 23-03-2015 WILEY‐VCH Verlag Wiley Subscription Services, Inc
Subjects:	ATP-Binding Cassette Transporters - chemistry ATP-Binding Cassette Transporters - metabolism Bacterial Proteins - chemistry Bacterial Proteins - metabolism Binding sites Biological Transport Drug Design energy-coupling factor transporter Lactococcus lactis - chemistry membrane proteins Models, Molecular molecular recognition Molecular Structure Small Molecule Libraries - chemistry Small Molecule Libraries - metabolism structure-based design Thiamine - chemical synthesis Thiamine - chemistry Thiamine - metabolism Vitamin B X-ray diffraction energy-coupling factor transporter X-ray diffraction molecular recognition membrane proteins structure-based design
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