Acute myeloid leukaemia cells secrete a soluble factor that inhibits T and NK cell proliferation but not cytolytic function – implications for the adoptive immunotherapy of leukaemia

Evidence of an immune mediated graft‐versus‐leukaemia effect has led to the belief that T and NK cell based adoptive immunotherapy can constitute effective treatment for relapsed leukaemias. However, work on solid tumours has shown this strategy may be hampered, by an immune escape mechanism in whic...

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Bibliographic Details
Published in:	Clinical and experimental immunology Vol. 126; no. 3; pp. 403 - 411
Main Authors:	Orleans‐Lindsay, J. K., Barber, L. D., Prentice, H. G., Lowdell, M. W.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Science Ltd 01-12-2001 Blackwell Oxford University Press Blackwell Science Inc
Subjects:	adoptive immunotherapy Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Applied cell therapy and gene therapy Biological and medical sciences Cancer Immunology Cell Division Cytotoxicity, Immunologic Graft vs Leukemia Effect - immunology graft‐versus‐leukaemia HL-60 Cells Humans Immunotherapy, Adoptive Interleukin-15 - pharmacology Interleukin-2 - pharmacology Isoantigens - administration & dosage K562 Cells Killer Cells, Natural - immunology Killer Cells, Natural - pathology Leukemia, Myeloid, Acute - immunology Leukemia, Myeloid, Acute - pathology Leukemia, Myeloid, Acute - therapy Lymphocyte Activation Medical sciences Mitogens - pharmacology Suppressor Factors, Immunologic - metabolism T-Lymphocytes - immunology T-Lymphocytes - pathology Transfusions. Complications. Transfusion reactions. Cell and gene therapy Tumor Cells, Cultured tumour induced immunosuppression Human Graft versus leukemia reaction Immune response Cell therapy Acute Stem cell Hematopoietic cell Homograft Cytotoxicity Malignant hemopathy Adoptive transfer Natural killer cell Immunosuppression Treatment Immunotherapy T-Lymphocyte Graft Tumor cell Acute myelocytic leukemia
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