Chip and Apterous Physically Interact to Form a Functional Complex during Drosophila Development
LIM homeodomain (LIM-HD) proteins play key roles in a variety of developmental processes throughout the animal kingdom. Here we show that the LIM-binding protein Chip acts as a cofactor for the Drosophila LIM-HD family member Apterous (Ap) in wing development. We define the domains of Chip required...
Saved in:
| Published in: | Molecular cell Vol. 4; no. 2; pp. 259 - 265 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Elsevier Inc
01-08-1999
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | LIM homeodomain (LIM-HD) proteins play key roles in a variety of developmental processes throughout the animal kingdom. Here we show that the LIM-binding protein Chip acts as a cofactor for the
Drosophila LIM-HD family member Apterous (Ap) in wing development. We define the domains of Chip required for LIM-HD binding and for homodimerization and show that mutant proteins deleted for these domains act in a dominant-negative fashion to disrupt Ap function. Our results support a model for multimeric complexes containing Chip and Ap in transcriptional regulation. This model is confirmed by the activity of a chimeric fusion between Chip and Ap that reconstitutes the complex and rescues the
ap mutant phenotype. |
|---|---|
| AbstractList | LIM homeodomain (LIM-HD) proteins play key roles in a variety of developmental processes throughout the animal kingdom. Here we show that the LIM-binding protein Chip acts as a cofactor for the Drosophila LIM-HD family member Apterous (Ap) in wing development. We define the domains of Chip required for LIM-HD binding and for homodimerization and show that mutant proteins deleted for these domains act in a dominant-negative fashion to disrupt Ap function. Our results support a model for multimeric complexes containing Chip and Ap in transcriptional regulation. This model is confirmed by the activity of a chimeric fusion between Chip and Ap that reconstitutes the complex and rescues the ap mutant phenotype. LIM homeodomain (LIM-HD) proteins play key roles in a variety of developmental processes throughout the animal kingdom. Here we show that the LIM-binding protein Chip acts as a cofactor for the Drosophila LIM-HD family member Apterous (Ap) in wing development. We define the domains of Chip required for LIM-HD binding and for homodimerization and show that mutant proteins deleted for these domains act in a dominant-negative fashion to disrupt Ap function. Our results support a model for multimeric complexes containing Chip and Ap in transcriptional regulation. This model is confirmed by the activity of a chimeric fusion between Chip and Ap that reconstitutes the complex and rescues the ap mutant phenotype. |
| Author | van Meyel, Donald J Jurata, Linda W Thor, Stefan Gill, Gordon N O'Keefe, David D Thomas, John B |
| Author_xml | – sequence: 1 givenname: Donald J surname: van Meyel fullname: van Meyel, Donald J organization: The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA – sequence: 2 givenname: David D surname: O'Keefe fullname: O'Keefe, David D organization: The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA – sequence: 3 givenname: Linda W surname: Jurata fullname: Jurata, Linda W organization: The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA – sequence: 4 givenname: Stefan surname: Thor fullname: Thor, Stefan organization: The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA – sequence: 5 givenname: Gordon N surname: Gill fullname: Gill, Gordon N organization: Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA – sequence: 6 givenname: John B surname: Thomas fullname: Thomas, John B email: jthomas@salk.edu organization: The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/10488341$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkUlvFDEQhS0URBb4CSCfEDk0lJdefELRhAmRIoEEnI3brmGMuu3G7o6Yf49nOXDLqUpPX1Wp3rskZyEGJOQ1g_cMWPPhGwPVVrxt6ncA1x2IVlTsGbk4yJI18uzU75FzcpnzbwAm6069IOcMZNcJyS7Iz9XWT9QER2-mGVNcMv263WVvzTDs6H0omrEznSNdxzRSQ9dLsLOPwQx0FcdpwL_ULcmHX_Q2xRynrR8MvcVHHOI0YphfkucbM2R8dapX5Mf60_fV5-rhy9396uahsnXdzpVTnTMCRC2t6EFw3vauRw5Cms5hzXnduLpomx6UahTrN4qhFEbJhisurLgib497pxT_LJhnPfpscRhMwPKVbgFkAcWTIGuFhI7zAtZH0JbHcsKNnpIfTdppBnqfgT5koPcGawB9yECzMvfmdGDpR3T_TR1NL8DHI4DFj0ePSWfrMVh0PqGdtYv-iRP_AE1Ol-o |
| CitedBy_id | crossref_primary_10_1016_j_brainres_2018_02_046 crossref_primary_10_1002_dvg_23030 crossref_primary_10_1016_j_ydbio_2010_10_037 crossref_primary_10_1523_JNEUROSCI_1882_08_2008 crossref_primary_10_1046_j_1365_2443_2002_00600_x crossref_primary_10_1146_annurev_cellbio_16_1_243 crossref_primary_10_1371_journal_pbio_3001459 crossref_primary_10_1242_dev_127_24_5309 crossref_primary_10_1006_dbio_2000_9778 crossref_primary_10_1242_dev_127_24_5391 crossref_primary_10_1016_S0925_4773_99_00314_7 crossref_primary_10_1371_journal_pgen_1005376 crossref_primary_10_1016_j_bbagen_2014_12_026 crossref_primary_10_1101_gad_239749_114 crossref_primary_10_3389_fphys_2020_00997 crossref_primary_10_1002_stem_1500 crossref_primary_10_1002_wsbm_1511 crossref_primary_10_1242_dev_129_21_4879 crossref_primary_10_1038_s41598_017_04587_8 crossref_primary_10_1074_jbc_275_18_13336 crossref_primary_10_1242_dev_127_14_3069 crossref_primary_10_1002__SICI_1521_1878_200004_22_4_311__AID_BIES1_3_0_CO_2_J crossref_primary_10_1002_1526_968X_200005_27_1_12__AID_GENE30_3_0_CO_2_X crossref_primary_10_1242_dev_187856 crossref_primary_10_1038_sj_onc_1209318 crossref_primary_10_1016_S0092_8674_02_00823_1 crossref_primary_10_1242_dev_01161 crossref_primary_10_18699_VJ18_449 crossref_primary_10_1016_j_bbrc_2008_06_027 crossref_primary_10_1016_S0166_2236_02_00029_2 crossref_primary_10_1073_pnas_212532399 crossref_primary_10_1091_mbc_11_10_3299 crossref_primary_10_1016_S0896_6273_01_00307_5 crossref_primary_10_1242_dev_00621 crossref_primary_10_1016_j_molmet_2021_101284 crossref_primary_10_1073_pnas_050586397 crossref_primary_10_1242_dev_00389 crossref_primary_10_1242_dev_01319 crossref_primary_10_1016_j_ydbio_2008_01_040 crossref_primary_10_1016_S0896_6273_01_00283_5 crossref_primary_10_1523_ENEURO_0356_18_2019 crossref_primary_10_1074_jbc_M111_248559 crossref_primary_10_1242_dev_02844 crossref_primary_10_1016_S1097_2765_05_00079_1 crossref_primary_10_1242_dev_129734 crossref_primary_10_1038_srep18937 crossref_primary_10_1242_dev_127_9_1823 crossref_primary_10_1016_j_neuropharm_2008_07_023 crossref_primary_10_4161_fly_5_3_14854 crossref_primary_10_1006_dbio_2000_9986 crossref_primary_10_1016_j_cub_2006_11_067 crossref_primary_10_1128_MCB_24_4_1439_1452_2004 crossref_primary_10_1101_gad_1528507 crossref_primary_10_1038_sj_emboj_7600376 crossref_primary_10_1111_nyas_13012 crossref_primary_10_1038_416099a crossref_primary_10_1093_cercor_bhp030 crossref_primary_10_1006_geno_2000_6311 crossref_primary_10_1242_dev_037986 crossref_primary_10_1134_S1062360415030029 crossref_primary_10_1016_S0959_4388_99_00053_7 crossref_primary_10_1242_dev_01844 crossref_primary_10_1242_dev_041244 crossref_primary_10_1038_nn750 crossref_primary_10_1016_S0896_6273_03_00296_4 crossref_primary_10_1016_j_neuron_2009_02_011 crossref_primary_10_1016_j_ydbio_2005_09_033 crossref_primary_10_1016_j_mcn_2004_06_016 crossref_primary_10_1074_jbc_M101782200 crossref_primary_10_1073_pnas_2211189119 crossref_primary_10_1128_MCB_23_21_7585_7599_2003 crossref_primary_10_1016_j_mod_2010_05_001 crossref_primary_10_1016_j_gim_2023_100839 crossref_primary_10_1016_S1097_2765_00_80374_3 crossref_primary_10_1016_S0925_4773_02_00178_8 crossref_primary_10_1242_dev_128_22_4615 crossref_primary_10_1016_S0092_8674_01_00489_5 crossref_primary_10_1371_journal_pgen_1001063 crossref_primary_10_1534_genetics_108_090076 crossref_primary_10_1016_j_ydbio_2008_12_036 crossref_primary_10_1038_nrm1499 crossref_primary_10_1038_srep37255 crossref_primary_10_1016_j_bbrc_2010_04_160 crossref_primary_10_1016_j_bbrc_2015_12_089 crossref_primary_10_1016_j_conb_2004_01_006 crossref_primary_10_1006_dbio_2000_9846 crossref_primary_10_7554_eLife_09073 crossref_primary_10_1042_BJ20091461 crossref_primary_10_1242_dev_01418 crossref_primary_10_1534_genetics_107_081869 crossref_primary_10_1007_s12038_018_9731_z crossref_primary_10_1016_j_ydbio_2003_09_002 crossref_primary_10_1128_MCB_00901_15 |
| Cites_doi | 10.1093/nar/15.4.1353 10.1242/dev.125.19.3915 10.1242/dev.124.15.2935 10.1073/pnas.91.1.316 10.1242/dev.121.6.1769 10.1016/S1097-2765(00)80374-3 10.1242/dev.118.2.401 10.1074/jbc.273.6.3152 10.1016/S0896-6273(00)81241-6 10.1073/pnas.93.21.11693 10.1101/gad.11.11.1370 10.1101/gad.10.3.289 10.1101/gad.6.5.715 10.1073/pnas.90.10.4404 10.1126/science.284.5417.1155 10.1038/374425a0 10.1038/ng0598-47 10.1016/0092-8674(94)90191-0 10.1101/gad.12.18.2912 10.1126/science.274.5285.252 10.1101/gad.11.20.2729 10.1038/16275 10.1093/genetics/150.1.283 10.1016/S0092-8674(00)80985-X 10.1016/S0896-6273(00)80944-7 10.1128/MCB.17.7.3488 10.1073/pnas.92.7.2720 10.1093/emboj/17.23.6846 10.1016/0092-8674(88)90174-2 10.1242/dev.120.7.1805 10.1016/S0092-8674(00)81704-3 10.1016/0092-8674(93)90494-B 10.1016/0378-1119(89)90358-2 10.1038/384270a0 10.1126/science.6289436 10.1038/372783a0 10.1038/ng0598-51 |
| ContentType | Journal Article |
| Copyright | 1999 Cell Press |
| Copyright_xml | – notice: 1999 Cell Press |
| DBID | 6I. AAFTH CGR CUY CVF ECM EIF NPM AAYXX CITATION 7SS 8FD FR3 P64 RC3 7X8 |
| DOI | 10.1016/S1097-2765(00)80373-1 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Entomology Abstracts (Full archive) Technology Research Database Engineering Research Database Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Entomology Abstracts Genetics Abstracts Engineering Research Database Technology Research Database Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE Entomology Abstracts |
| Database_xml | – sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1097-4164 |
| EndPage | 265 |
| ExternalDocumentID | 10_1016_S1097_2765_00_80373_1 10488341 S1097276500803731 |
| Genre | Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S Journal Article |
| GrantInformation_xml | – fundername: NIDDK NIH HHS grantid: DK13149 |
| GroupedDBID | --- --K -DZ -~X .55 .GJ 0R~ 123 1~5 29M 2WC 3O- 4.4 457 4G. 53G 5RE 5VS 62- 6I. 7-5 AACTN AAEDT AAEDW AAFTH AAIAV AAIKJ AAKRW AAKUH AALRI AAQFI AAQXK AAUCE AAVLU AAXJY AAXUO ABJNI ABMAC ABMWF ABVKL ACGFO ACGFS ACNCT ADBBV ADEZE ADJPV ADMUD AEFWE AENEX AEXQZ AFFNX AFTJW AGHFR AGKMS AHPSJ AITUG ALKID ALMA_UNASSIGNED_HOLDINGS AMRAJ ASPBG AVWKF AZFZN BAWUL CS3 DIK DU5 E3Z EBS EJD F5P FCP FDB FEDTE FGOYB FIRID HH5 HVGLF HZ~ IH2 IHE IXB J1W JIG KQ8 L7B M3Z M41 N9A NCXOZ O-L O9- OK1 OZT P2P R2- RCE RIG ROL RPZ SDG SES SSZ TR2 UHS WQ6 X7M ZA5 ZGI ZXP 0SF AAHBH AAMRU ADVLN AKAPO AKRWK CGR CUY CVF ECM EIF NPM AAYXX CITATION 7SS 8FD FR3 P64 RC3 7X8 |
| ID | FETCH-LOGICAL-c557t-d98da30354c3b03227bdbe2034a8de52256d57bdfb099691bf91e43a9462923c3 |
| ISSN | 1097-2765 |
| IngestDate | Fri Oct 25 10:40:37 EDT 2024 Thu Oct 24 23:02:37 EDT 2024 Thu Sep 26 17:39:58 EDT 2024 Sat Sep 28 07:34:39 EDT 2024 Fri Feb 23 02:17:18 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| License | http://www.elsevier.com/open-access/userlicense/1.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c557t-d98da30354c3b03227bdbe2034a8de52256d57bdfb099691bf91e43a9462923c3 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
| OpenAccessLink | https://dx.doi.org/10.1016/S1097-2765(00)80373-1 |
| PMID | 10488341 |
| PQID | 17340822 |
| PQPubID | 23462 |
| PageCount | 7 |
| ParticipantIDs | proquest_miscellaneous_70049233 proquest_miscellaneous_17340822 crossref_primary_10_1016_S1097_2765_00_80373_1 pubmed_primary_10488341 elsevier_sciencedirect_doi_10_1016_S1097_2765_00_80373_1 |
| PublicationCentury | 1900 |
| PublicationDate | 1999-08-01 |
| PublicationDateYYYYMMDD | 1999-08-01 |
| PublicationDate_xml | – month: 08 year: 1999 text: 1999-08-01 day: 01 |
| PublicationDecade | 1990 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Molecular cell |
| PublicationTitleAlternate | Mol Cell |
| PublicationYear | 1999 |
| Publisher | Elsevier Inc |
| Publisher_xml | – name: Elsevier Inc |
| References | Milán, Cohen (BIB22) 1999; 4 Shoresh, Orgad, Shmueli, Werczberger, Gelbaum, Abiri, Segal (BIB32) 1998; 150 Archer, Breton, Sanchez-Garcia, Osada, Forster, Thomson, Rabbitts (BIB3) 1994; 91 Milán, Diaz-Benjumea, Cohen (BIB23) 1998; 12 Staehling-Hampton, Hoffmann, Baylies, Rushton, Bate (BIB33) 1994; 372 Thor, Thomas (BIB34) 1997; 18 Diaz-Benjumea, Cohen (BIB12) 1993; 75 Chen, Lun, Ovchinnikov, Kokubo, Oberg, Pepicelli, Gan, Lee, Johnson (BIB10) 1998; 19 Hobert, Mori, Yamashita, Honda, Ohshima, Lui, Ruvkun (BIB16) 1997; 19 Dreyer, Zhou, Baldini, Winterpacht, Zabel, Cole, Johnson, Lee (BIB13) 1998; 19 Pfaff, Mendelsohn, Stewart, Edlund, Jessell (BIB26) 1996; 84 Bach, Carriere, Ostendorff, Andersen, Rosenfeld (BIB5) 1997; 11 Blair, Brower, Thomas, Zavortink (BIB6) 1994; 120 Porter, Drago, Xu, Cheema, Wassif, Huang, Lee, Grinberg, Massalas, Bodine (BIB27) 1997; 124 Jurata, Pfaff, Gill (BIB19) 1998; 273 Way, Chalfie (BIB36) 1988; 54 Rubin, Spradling (BIB28) 1982; 218 Lundgren, Callahan, Thor, Thomas (BIB20) 1995; 121 Sharma, Sheng, Lettieri, Li, Karavanov, Potter, Westphal, Pfaff (BIB30) 1998; 95 Bach, Rhodes, Pearse, Heinzel, Gloss, Scully, Sawchenko, Rosenfeld (BIB4) 1995; 92 Michelsen, Schmeichel, Beckerle, Winge (BIB21) 1993; 90 Schmeichel, Beckerle (BIB29) 1994; 79 Fernandez-Funez, Lu, Rincon-Limas, Garcia-Bellido, Botas (BIB14) 1998; 17 O'Keefe, Thor, Thomas (BIB25) 1998; 125 Agulnick, Taira, Breen, Tanaka, Dawid, Westphal (BIB1) 1996; 384 Arber, Caroni (BIB2) 1996; 10 Cavener (BIB9) 1987; 15 Cohen, McGuffin, Pfeifle, Segal, Cohen (BIB11) 1992; 6 Zhu, Bodem, Keppel, Paro, Royer-Pokora (BIB38) 1995; 11 Jurata, Kenny, Gill (BIB18) 1996; 93 Shawlot, Behringer (BIB31) 1995; 374 Morcillo, Rosen, Baylies, Dorsett (BIB24) 1997; 11 Brand, Perrimon (BIB7) 1993; 118 Zhao, Sheng, Amini, Grinberg, Lee, Huang, Taira, Westphal (BIB37) 1999; 284 Thor, Andersson, Tomlinson, Thomas (BIB35) 1999; 397 Calleja, Moreno, Pelaz, Morata (BIB8) 1996; 274 Ho, Hunt, Horton, Pullen, Pease (BIB15) 1989; 77 Johnson, Zhang, Rudnick, Rutter, German (BIB17) 1997; 17 Brand (10.1016/S1097-2765(00)80373-1_BIB7) 1993; 118 Cohen (10.1016/S1097-2765(00)80373-1_BIB11) 1992; 6 Thor (10.1016/S1097-2765(00)80373-1_BIB34) 1997; 18 Jurata (10.1016/S1097-2765(00)80373-1_BIB19) 1998; 273 Michelsen (10.1016/S1097-2765(00)80373-1_BIB21) 1993; 90 Shawlot (10.1016/S1097-2765(00)80373-1_BIB31) 1995; 374 Way (10.1016/S1097-2765(00)80373-1_BIB36) 1988; 54 Zhao (10.1016/S1097-2765(00)80373-1_BIB37) 1999; 284 Staehling-Hampton (10.1016/S1097-2765(00)80373-1_BIB33) 1994; 372 Johnson (10.1016/S1097-2765(00)80373-1_BIB17) 1997; 17 Rubin (10.1016/S1097-2765(00)80373-1_BIB28) 1982; 218 Lundgren (10.1016/S1097-2765(00)80373-1_BIB20) 1995; 121 Dreyer (10.1016/S1097-2765(00)80373-1_BIB13) 1998; 19 Schmeichel (10.1016/S1097-2765(00)80373-1_BIB29) 1994; 79 Agulnick (10.1016/S1097-2765(00)80373-1_BIB1) 1996; 384 Calleja (10.1016/S1097-2765(00)80373-1_BIB8) 1996; 274 Hobert (10.1016/S1097-2765(00)80373-1_BIB16) 1997; 19 Diaz-Benjumea (10.1016/S1097-2765(00)80373-1_BIB12) 1993; 75 Sharma (10.1016/S1097-2765(00)80373-1_BIB30) 1998; 95 Zhu (10.1016/S1097-2765(00)80373-1_BIB38) 1995; 11 Bach (10.1016/S1097-2765(00)80373-1_BIB5) 1997; 11 Cavener (10.1016/S1097-2765(00)80373-1_BIB9) 1987; 15 Milán (10.1016/S1097-2765(00)80373-1_BIB22) 1999; 4 Morcillo (10.1016/S1097-2765(00)80373-1_BIB24) 1997; 11 Shoresh (10.1016/S1097-2765(00)80373-1_BIB32) 1998; 150 Bach (10.1016/S1097-2765(00)80373-1_BIB4) 1995; 92 O'Keefe (10.1016/S1097-2765(00)80373-1_BIB25) 1998; 125 Jurata (10.1016/S1097-2765(00)80373-1_BIB18) 1996; 93 Milán (10.1016/S1097-2765(00)80373-1_BIB23) 1998; 12 Fernandez-Funez (10.1016/S1097-2765(00)80373-1_BIB14) 1998; 17 Arber (10.1016/S1097-2765(00)80373-1_BIB2) 1996; 10 Chen (10.1016/S1097-2765(00)80373-1_BIB10) 1998; 19 Pfaff (10.1016/S1097-2765(00)80373-1_BIB26) 1996; 84 Blair (10.1016/S1097-2765(00)80373-1_BIB6) 1994; 120 Ho (10.1016/S1097-2765(00)80373-1_BIB15) 1989; 77 Porter (10.1016/S1097-2765(00)80373-1_BIB27) 1997; 124 Thor (10.1016/S1097-2765(00)80373-1_BIB35) 1999; 397 Archer (10.1016/S1097-2765(00)80373-1_BIB3) 1994; 91 |
| References_xml | – volume: 91 start-page: 316 year: 1994 end-page: 320 ident: BIB3 article-title: Cysteine-rich LIM domains of LIM-homeodomain and LIM-only proteins contain zinc but not iron publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Rabbitts – volume: 4 start-page: 267 year: 1999 end-page: 273 ident: BIB22 article-title: Regulation of LIM homeodomain activity in vivo publication-title: Mol. Cell contributor: fullname: Cohen – volume: 75 start-page: 741 year: 1993 end-page: 752 ident: BIB12 article-title: Interaction between dorsal and ventral cells in the imaginal disc directs wing development in Drosophila publication-title: Cell contributor: fullname: Cohen – volume: 54 start-page: 5 year: 1988 end-page: 16 ident: BIB36 article-title: publication-title: Cell contributor: fullname: Chalfie – volume: 11 start-page: 1370 year: 1997 end-page: 1380 ident: BIB5 article-title: A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins publication-title: Genes Dev. contributor: fullname: Rosenfeld – volume: 125 start-page: 3915 year: 1998 end-page: 3923 ident: BIB25 article-title: Function and specificity of LIM domains in publication-title: Development contributor: fullname: Thomas – volume: 284 start-page: 115 year: 1999 end-page: 118 ident: BIB37 article-title: Control of hippocampal morphogenesis and neuronal differentiation by the LIM homeobox gene Lhx5 publication-title: Science contributor: fullname: Westphal – volume: 12 start-page: 2912 year: 1998 end-page: 2920 ident: BIB23 article-title: Beadex encodes an LMO protein that regulates Apterous LIM-homeodomain activity in publication-title: Genes Dev. contributor: fullname: Cohen – volume: 10 start-page: 289 year: 1996 end-page: 300 ident: BIB2 article-title: Specificity of single LIM motifs in targeting and LIM/LIM interactions in situ publication-title: Genes Dev. contributor: fullname: Caroni – volume: 95 start-page: 817 year: 1998 end-page: 828 ident: BIB30 article-title: LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons publication-title: Cell contributor: fullname: Pfaff – volume: 90 start-page: 4404 year: 1993 end-page: 4408 ident: BIB21 article-title: The LIM motif defines a specific zinc-binding protein domain publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Winge – volume: 11 start-page: 2729 year: 1997 end-page: 2740 ident: BIB24 article-title: Chip, a widely expressed chromosomal protein required for segmentation and activity of a remote wing margin enhancer in publication-title: Genes Dev. contributor: fullname: Dorsett – volume: 84 start-page: 309 year: 1996 end-page: 320 ident: BIB26 article-title: Requirement for LIM homeobox gene publication-title: Cell contributor: fullname: Jessell – volume: 18 start-page: 397 year: 1997 end-page: 409 ident: BIB34 article-title: The Drosophila publication-title: Neuron contributor: fullname: Thomas – volume: 120 start-page: 1805 year: 1994 end-page: 1815 ident: BIB6 article-title: The role of publication-title: Development contributor: fullname: Zavortink – volume: 374 start-page: 425 year: 1995 end-page: 430 ident: BIB31 article-title: Requirement for Lim1 in head-organizer function publication-title: Nature contributor: fullname: Behringer – volume: 397 start-page: 76 year: 1999 end-page: 80 ident: BIB35 article-title: A LIM-homeodomain combinatorial code for motor-neuron pathway selection publication-title: Nature contributor: fullname: Thomas – volume: 19 start-page: 51 year: 1998 end-page: 55 ident: BIB10 article-title: Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome publication-title: Nat. Genet. contributor: fullname: Johnson – volume: 6 start-page: 715 year: 1992 end-page: 729 ident: BIB11 article-title: apterous, a gene required for imaginal disc development in publication-title: Genes Dev. contributor: fullname: Cohen – volume: 218 start-page: 348 year: 1982 end-page: 353 ident: BIB28 article-title: Genetic transformation of publication-title: Science contributor: fullname: Spradling – volume: 17 start-page: 3488 year: 1997 end-page: 3496 ident: BIB17 article-title: Transcriptional synergy between LIM-homeodomain proteins and basic helix-loop-helix proteins publication-title: Mol. Cell. Biol. contributor: fullname: German – volume: 150 start-page: 283 year: 1998 end-page: 299 ident: BIB32 article-title: Overexpression Beadex mutations and loss-of-function heldup-a mutations in publication-title: Genetics contributor: fullname: Segal – volume: 77 start-page: 51 year: 1989 end-page: 59 ident: BIB15 article-title: Site-directed mutagenesis by overlap extension using the polymerase chain reaction publication-title: Gene contributor: fullname: Pease – volume: 274 start-page: 252 year: 1996 end-page: 255 ident: BIB8 article-title: Visualization of gene expression in living adult publication-title: Science contributor: fullname: Morata – volume: 11 start-page: 1283 year: 1995 end-page: 1290 ident: BIB38 article-title: A single ancestral gene of the human LIM domain oncogene family LMO in publication-title: Oncogene contributor: fullname: Royer-Pokora – volume: 19 start-page: 345 year: 1997 end-page: 357 ident: BIB16 article-title: Regulation of interneuron function in the C. elegans thermoregulatory pathway by the publication-title: Neuron contributor: fullname: Ruvkun – volume: 93 start-page: 11693 year: 1996 end-page: 11698 ident: BIB18 article-title: Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Gill – volume: 121 start-page: 1769 year: 1995 end-page: 1773 ident: BIB20 article-title: Control of neuronal pathway selection by the publication-title: Development contributor: fullname: Thomas – volume: 17 start-page: 6846 year: 1998 end-page: 6853 ident: BIB14 article-title: The relative expression amounts of apterous and its co-factor dLdb/Chip are critical for dorso-ventral compartmentalization in the publication-title: EMBO J. contributor: fullname: Botas – volume: 118 start-page: 401 year: 1993 end-page: 415 ident: BIB7 article-title: Targeted gene expression as a means of altering cell fates and generating dominant phenotypes publication-title: Development contributor: fullname: Perrimon – volume: 372 start-page: 783 year: 1994 end-page: 786 ident: BIB33 article-title: dpp induces mesodermal gene expression in publication-title: Nature contributor: fullname: Bate – volume: 92 start-page: 2720 year: 1995 end-page: 2724 ident: BIB4 article-title: P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1 publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Rosenfeld – volume: 19 start-page: 47 year: 1998 end-page: 50 ident: BIB13 article-title: Mutations in LMX1B cause abnormal skeletal patterning and renal dysplasia in nail patella syndrome publication-title: Nat. Genet. contributor: fullname: Lee – volume: 273 start-page: 3152 year: 1998 end-page: 3157 ident: BIB19 article-title: The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors publication-title: J. Biol. Chem. contributor: fullname: Gill – volume: 79 start-page: 211 year: 1994 end-page: 219 ident: BIB29 article-title: The LIM domain is a modular protein-binding interface publication-title: Cell contributor: fullname: Beckerle – volume: 384 start-page: 270 year: 1996 end-page: 272 ident: BIB1 article-title: Interactions of the LIM-domain-binding factor Lbd1 with LIM homeodomain proteins publication-title: Nature contributor: fullname: Westphal – volume: 15 start-page: 1353 year: 1987 end-page: 1361 ident: BIB9 article-title: Comparison of consensus flanking translational start sites in publication-title: Nucleic Acids Res. contributor: fullname: Cavener – volume: 124 start-page: 2935 year: 1997 end-page: 2944 ident: BIB27 article-title: publication-title: Development contributor: fullname: Bodine – volume: 15 start-page: 1353 year: 1987 ident: 10.1016/S1097-2765(00)80373-1_BIB9 article-title: Comparison of consensus flanking translational start sites in Drosophila and vertebrates publication-title: Nucleic Acids Res. doi: 10.1093/nar/15.4.1353 contributor: fullname: Cavener – volume: 125 start-page: 3915 year: 1998 ident: 10.1016/S1097-2765(00)80373-1_BIB25 article-title: Function and specificity of LIM domains in Drosophila nervous system and wing development publication-title: Development doi: 10.1242/dev.125.19.3915 contributor: fullname: O'Keefe – volume: 11 start-page: 1283 year: 1995 ident: 10.1016/S1097-2765(00)80373-1_BIB38 article-title: A single ancestral gene of the human LIM domain oncogene family LMO in Drosophila publication-title: Oncogene contributor: fullname: Zhu – volume: 124 start-page: 2935 year: 1997 ident: 10.1016/S1097-2765(00)80373-1_BIB27 article-title: Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development publication-title: Development doi: 10.1242/dev.124.15.2935 contributor: fullname: Porter – volume: 91 start-page: 316 year: 1994 ident: 10.1016/S1097-2765(00)80373-1_BIB3 article-title: Cysteine-rich LIM domains of LIM-homeodomain and LIM-only proteins contain zinc but not iron publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.91.1.316 contributor: fullname: Archer – volume: 121 start-page: 1769 year: 1995 ident: 10.1016/S1097-2765(00)80373-1_BIB20 article-title: Control of neuronal pathway selection by the Drosophila LIM homeodomain gene apterous publication-title: Development doi: 10.1242/dev.121.6.1769 contributor: fullname: Lundgren – volume: 4 start-page: 267 year: 1999 ident: 10.1016/S1097-2765(00)80373-1_BIB22 article-title: Regulation of LIM homeodomain activity in vivo publication-title: Mol. Cell doi: 10.1016/S1097-2765(00)80374-3 contributor: fullname: Milán – volume: 118 start-page: 401 year: 1993 ident: 10.1016/S1097-2765(00)80373-1_BIB7 article-title: Targeted gene expression as a means of altering cell fates and generating dominant phenotypes publication-title: Development doi: 10.1242/dev.118.2.401 contributor: fullname: Brand – volume: 273 start-page: 3152 year: 1998 ident: 10.1016/S1097-2765(00)80373-1_BIB19 article-title: The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors publication-title: J. Biol. Chem. doi: 10.1074/jbc.273.6.3152 contributor: fullname: Jurata – volume: 18 start-page: 397 year: 1997 ident: 10.1016/S1097-2765(00)80373-1_BIB34 article-title: The Drosophila islet gene governs axon pathfinding and neurotransmitter identity publication-title: Neuron doi: 10.1016/S0896-6273(00)81241-6 contributor: fullname: Thor – volume: 93 start-page: 11693 year: 1996 ident: 10.1016/S1097-2765(00)80373-1_BIB18 article-title: Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.93.21.11693 contributor: fullname: Jurata – volume: 11 start-page: 1370 year: 1997 ident: 10.1016/S1097-2765(00)80373-1_BIB5 article-title: A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins publication-title: Genes Dev. doi: 10.1101/gad.11.11.1370 contributor: fullname: Bach – volume: 10 start-page: 289 year: 1996 ident: 10.1016/S1097-2765(00)80373-1_BIB2 article-title: Specificity of single LIM motifs in targeting and LIM/LIM interactions in situ publication-title: Genes Dev. doi: 10.1101/gad.10.3.289 contributor: fullname: Arber – volume: 6 start-page: 715 year: 1992 ident: 10.1016/S1097-2765(00)80373-1_BIB11 article-title: apterous, a gene required for imaginal disc development in Drosophila encodes a member of the LIM family of developmental regulatory proteins publication-title: Genes Dev. doi: 10.1101/gad.6.5.715 contributor: fullname: Cohen – volume: 90 start-page: 4404 year: 1993 ident: 10.1016/S1097-2765(00)80373-1_BIB21 article-title: The LIM motif defines a specific zinc-binding protein domain publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.90.10.4404 contributor: fullname: Michelsen – volume: 284 start-page: 115 year: 1999 ident: 10.1016/S1097-2765(00)80373-1_BIB37 article-title: Control of hippocampal morphogenesis and neuronal differentiation by the LIM homeobox gene Lhx5 publication-title: Science doi: 10.1126/science.284.5417.1155 contributor: fullname: Zhao – volume: 374 start-page: 425 year: 1995 ident: 10.1016/S1097-2765(00)80373-1_BIB31 article-title: Requirement for Lim1 in head-organizer function publication-title: Nature doi: 10.1038/374425a0 contributor: fullname: Shawlot – volume: 19 start-page: 47 year: 1998 ident: 10.1016/S1097-2765(00)80373-1_BIB13 article-title: Mutations in LMX1B cause abnormal skeletal patterning and renal dysplasia in nail patella syndrome publication-title: Nat. Genet. doi: 10.1038/ng0598-47 contributor: fullname: Dreyer – volume: 79 start-page: 211 year: 1994 ident: 10.1016/S1097-2765(00)80373-1_BIB29 article-title: The LIM domain is a modular protein-binding interface publication-title: Cell doi: 10.1016/0092-8674(94)90191-0 contributor: fullname: Schmeichel – volume: 12 start-page: 2912 year: 1998 ident: 10.1016/S1097-2765(00)80373-1_BIB23 article-title: Beadex encodes an LMO protein that regulates Apterous LIM-homeodomain activity in Drosophila wing development publication-title: Genes Dev. doi: 10.1101/gad.12.18.2912 contributor: fullname: Milán – volume: 274 start-page: 252 year: 1996 ident: 10.1016/S1097-2765(00)80373-1_BIB8 article-title: Visualization of gene expression in living adult Drosophila publication-title: Science doi: 10.1126/science.274.5285.252 contributor: fullname: Calleja – volume: 11 start-page: 2729 year: 1997 ident: 10.1016/S1097-2765(00)80373-1_BIB24 article-title: Chip, a widely expressed chromosomal protein required for segmentation and activity of a remote wing margin enhancer in Drosophila publication-title: Genes Dev. doi: 10.1101/gad.11.20.2729 contributor: fullname: Morcillo – volume: 397 start-page: 76 year: 1999 ident: 10.1016/S1097-2765(00)80373-1_BIB35 article-title: A LIM-homeodomain combinatorial code for motor-neuron pathway selection publication-title: Nature doi: 10.1038/16275 contributor: fullname: Thor – volume: 150 start-page: 283 year: 1998 ident: 10.1016/S1097-2765(00)80373-1_BIB32 article-title: Overexpression Beadex mutations and loss-of-function heldup-a mutations in Drosophila affect the 3′ regulatory and coding components, respectively, of the Dlmo gene publication-title: Genetics doi: 10.1093/genetics/150.1.283 contributor: fullname: Shoresh – volume: 84 start-page: 309 year: 1996 ident: 10.1016/S1097-2765(00)80373-1_BIB26 article-title: Requirement for LIM homeobox gene Isl-1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation publication-title: Cell doi: 10.1016/S0092-8674(00)80985-X contributor: fullname: Pfaff – volume: 19 start-page: 345 year: 1997 ident: 10.1016/S1097-2765(00)80373-1_BIB16 article-title: Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene publication-title: Neuron doi: 10.1016/S0896-6273(00)80944-7 contributor: fullname: Hobert – volume: 17 start-page: 3488 year: 1997 ident: 10.1016/S1097-2765(00)80373-1_BIB17 article-title: Transcriptional synergy between LIM-homeodomain proteins and basic helix-loop-helix proteins publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.17.7.3488 contributor: fullname: Johnson – volume: 92 start-page: 2720 year: 1995 ident: 10.1016/S1097-2765(00)80373-1_BIB4 article-title: P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.92.7.2720 contributor: fullname: Bach – volume: 17 start-page: 6846 year: 1998 ident: 10.1016/S1097-2765(00)80373-1_BIB14 article-title: The relative expression amounts of apterous and its co-factor dLdb/Chip are critical for dorso-ventral compartmentalization in the Drosophila wing publication-title: EMBO J. doi: 10.1093/emboj/17.23.6846 contributor: fullname: Fernandez-Funez – volume: 54 start-page: 5 year: 1988 ident: 10.1016/S1097-2765(00)80373-1_BIB36 article-title: mec-3, a homeobox-containing gene that specifies differentiation of the touch receptor neurons in C. elegans publication-title: Cell doi: 10.1016/0092-8674(88)90174-2 contributor: fullname: Way – volume: 120 start-page: 1805 year: 1994 ident: 10.1016/S1097-2765(00)80373-1_BIB6 article-title: The role of apterous in the control of dorsoventral compartmentalization and PS integrin gene expression in the developing wing of Drosophila publication-title: Development doi: 10.1242/dev.120.7.1805 contributor: fullname: Blair – volume: 95 start-page: 817 year: 1998 ident: 10.1016/S1097-2765(00)80373-1_BIB30 article-title: LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons publication-title: Cell doi: 10.1016/S0092-8674(00)81704-3 contributor: fullname: Sharma – volume: 75 start-page: 741 year: 1993 ident: 10.1016/S1097-2765(00)80373-1_BIB12 article-title: Interaction between dorsal and ventral cells in the imaginal disc directs wing development in Drosophila publication-title: Cell doi: 10.1016/0092-8674(93)90494-B contributor: fullname: Diaz-Benjumea – volume: 77 start-page: 51 year: 1989 ident: 10.1016/S1097-2765(00)80373-1_BIB15 article-title: Site-directed mutagenesis by overlap extension using the polymerase chain reaction publication-title: Gene doi: 10.1016/0378-1119(89)90358-2 contributor: fullname: Ho – volume: 384 start-page: 270 year: 1996 ident: 10.1016/S1097-2765(00)80373-1_BIB1 article-title: Interactions of the LIM-domain-binding factor Lbd1 with LIM homeodomain proteins publication-title: Nature doi: 10.1038/384270a0 contributor: fullname: Agulnick – volume: 218 start-page: 348 year: 1982 ident: 10.1016/S1097-2765(00)80373-1_BIB28 article-title: Genetic transformation of Drosophila with transposable element vectors publication-title: Science doi: 10.1126/science.6289436 contributor: fullname: Rubin – volume: 372 start-page: 783 year: 1994 ident: 10.1016/S1097-2765(00)80373-1_BIB33 article-title: dpp induces mesodermal gene expression in Drosophila publication-title: Nature doi: 10.1038/372783a0 contributor: fullname: Staehling-Hampton – volume: 19 start-page: 51 year: 1998 ident: 10.1016/S1097-2765(00)80373-1_BIB10 article-title: Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome publication-title: Nat. Genet. doi: 10.1038/ng0598-51 contributor: fullname: Chen |
| SSID | ssj0014589 |
| Score | 1.990033 |
| Snippet | LIM homeodomain (LIM-HD) proteins play key roles in a variety of developmental processes throughout the animal kingdom. Here we show that the LIM-binding... |
| SourceID | proquest crossref pubmed elsevier |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 259 |
| SubjectTerms | Animals Animals, Genetically Modified Dimerization Drosophila Drosophila - genetics Drosophila - growth & development Drosophila - physiology Drosophila Proteins Gene Expression Regulation, Developmental Genes, Reporter Homeodomain Proteins Insect Proteins - metabolism LIM-Homeodomain Proteins Nuclear Proteins - genetics Nuclear Proteins - metabolism Recombinant Proteins - metabolism Transcription Factors - genetics Transcription Factors - metabolism Wings, Animal - abnormalities Wings, Animal - growth & development |
| Title | Chip and Apterous Physically Interact to Form a Functional Complex during Drosophila Development |
| URI | https://dx.doi.org/10.1016/S1097-2765(00)80373-1 https://www.ncbi.nlm.nih.gov/pubmed/10488341 https://search.proquest.com/docview/17340822 https://search.proquest.com/docview/70049233 |
| Volume | 4 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Li9swEBbplkIvpe-mTx16aAne2pZsWcdlk7Dt0lJICr25kiXTQsgu22TZ_PvOWJLlUkIf0IsJQpFszWfNN6MZDyEvhbWi1FYkuU6bhFeGJ4plOmGagX5PleYSc4dPFuLD52o647PRKNQNi23_VdLQBrLGzNm_kHY_KDTAb5A5XEHqcP0juR9j9BV6w4_OYckwwPWjF8Vq5_x_mBUJjHMObHWiJnNQbN4fiHvDyl6F1MXpRVfj4NtKDUOLhmz2faitO0H_f5DdZXf-s3PH_873HA-fMLjm1NrW9gH1Meb43RbgqHpPwaR3_yy_OqfCYmNbj2bjM_dkHybnvWchg-anAE88AE9y4epFHNrYBkSRD3dpPgBjPtxx_QfFnfLO3UC_6AXnolj0swF7xyLYskqZYEkWlWEfotj1xa7IqaETWNjXc9jMMGx0-va0P6niRVdmsR85Zom9idO9StPXfqp9_GeffdPxnOVtcssbKPTIIesOGdn1XXLDlSzd3SNfEF8U8EUDvmjEFw34opsziviiikZ8UY8v6vBFI77oAF_3yaf5bHl8kvgqHUlTFGKTGFkZBUSo4A3TKegHoY22ecq4qowFel-UpoC2VoMxUspMtzKznCnJyxysi4Y9IAfrs7V9RKjRrdBg4IJJLbk1TcVKaWRZNJli1pR2TA7D2tXn7mMsdR-l2IVS4GLXaVp3i11nY1KFFa49o3RMsQZg_O6vL4JEathx8TVSawurWmeCYZX2fH8PLBkBj8bG5KET5eBuQWECcXz87zf2hNyMb9dTcrC52Npn5Np3s33eIfMHmomx2A |
| link.rule.ids | 315,782,786,27935,27936 |
| linkProvider | Flying Publisher |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Chip+and+Apterous+Physically+Interact+to+Form+a+Functional+Complex+during+Drosophila+Development&rft.jtitle=Molecular+cell&rft.au=van+Meyel%2C+Donald+J&rft.au=O%27Keefe%2C+David+D&rft.au=Jurata%2C+Linda+W&rft.au=Thor%2C+Stefan&rft.date=1999-08-01&rft.pub=Elsevier+Inc&rft.issn=1097-2765&rft.eissn=1097-4164&rft.volume=4&rft.issue=2&rft.spage=259&rft.epage=265&rft_id=info:doi/10.1016%2FS1097-2765%2800%2980373-1&rft.externalDocID=S1097276500803731 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1097-2765&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1097-2765&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1097-2765&client=summon |