Trial Readiness in Cavernous Angiomas With Symptomatic Hemorrhage (CASH)

Abstract BACKGROUND Brain cavernous angiomas with symptomatic hemorrhage (CASH) are uncommon but exact a heavy burden of neurological disability from recurrent bleeding, for which there is no proven therapy. Candidate drugs to stabilize the CASH lesion and prevent rebleeding will ultimately require...

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Bibliographic Details
Published in:	Neurosurgery Vol. 84; no. 4; pp. 954 - 964
Main Authors:	Polster, Sean P, Cao, Ying, Carroll, Timothy, Flemming, Kelly, Girard, Romuald, Hanley, Daniel, Hobson, Nicholas, Kim, Helen, Koenig, James, Koskimäki, Janne, Lane, Karen, Majersik, Jennifer J, McBee, Nichol, Morrison, Leslie, Shenkar, Robert, Stadnik, Agnieszka, Thompson, Richard E, Zabramski, Joseph, Zeineddine, Hussein A, Awad, Issam A
Format:	Journal Article
Language:	English
Published:	United States Oxford University Press 01-04-2019 Copyright by the Congress of Neurological Surgeons Wolters Kluwer Health, Inc
Subjects:	Biological markers Biomarkers Brain Central Nervous System Neoplasms Clinical trials Cohort Studies Disabilities Diseases Epidemiology Evidence-based medicine Feasibility Studies Hemangioma, Cavernous, Central Nervous System Hemorrhage Hemorrhage - etiology Humans Infrastructure (Economics) Medical research Nervous system diseases Permeability Research—Human—Study Protocols Safety regulations Time Maryland Illinois California Cerebral cavernous malformation (CCM) Biomarkers Symptomatic hemorrhage Drug development Trial readiness Cavernous angioma
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