Carbazomycins C, D, E and F, minor components of the carbazomycin complex

Carbazomycins C (III), D (IV), E (V) and F (VI), the minor components of the carbazomycin complex, were isolated from the cultured broth of Streptoverticillium ehimense together with carbazomycins A (II) and B (I). Among them, III and IV were shown to be new substances and their structures were eluc...

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Bibliographic Details
Published in:	Journal of antibiotics Vol. 40; no. 2; p. 157
Main Authors:	Naid, T, Kitahara, T, Kaneda, M, Nakamura, S
Format:	Journal Article
Language:	English
Published:	Japan 1987
Subjects:	Anti-Bacterial Agents Antifungal Agents Carbazoles - isolation & purification Chemical Phenomena Chemistry, Physical Chromatography, Thin Layer Magnetic Resonance Spectroscopy Streptomyces - analysis Structure-Activity Relationship
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Summary:	Carbazomycins C (III), D (IV), E (V) and F (VI), the minor components of the carbazomycin complex, were isolated from the cultured broth of Streptoverticillium ehimense together with carbazomycins A (II) and B (I). Among them, III and IV were shown to be new substances and their structures were elucidated as 4-hydroxy-3,6-dimethoxy-1,2-dimethylcarbazole and 3,4,6-trimethoxy-12-dimethylcarbazole, respectively, by spectroscopic and chemical means. The other components, V and VI, were found to contain an aldehyde function and were identified as carbazomycinal and 6-methoxycarbazomycinal, respectively. The antimicrobial activity of III and IV are also reported.
ISSN:	0021-8820
DOI:	10.7164/antibiotics.40.157