Reovirus as a successful ex vivo purging modality for multiple myeloma

Autologous stem cell rescue (ASCT) following high-dose myeloablative chemotherapy is considered to be a therapeutic option for many multiple myeloma (MM) patients; however relapse post ASCT presents a major challenge. The oncolytic potential of reovirus has been previously demonstrated and is curren...

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Bibliographic Details
Published in:	Bone marrow transplantation (Basingstoke) Vol. 49; no. 1; pp. 80 - 86
Main Authors:	Thirukkumaran, C M, Shi, Z Q, Luider, J, Kopciuk, K, Bahlis, N, Neri, P, Pho, M, Stewart, D, Mansoor, A, Morris, D G
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-01-2014 Nature Publishing Group
Subjects:	631/250/1854/2813 692/699/67/1990/804 692/700/565/1331 692/700/565/545/576 Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Blood Component Removal Bone marrow Bone Marrow Purging - methods Bone marrow, stem cells transplantation. Graft versus host reaction Cancer Care and treatment Cell Biology Cell Line Cell Line, Tumor Flow Cytometry Green Fluorescent Proteins - chemistry Hematologic and hematopoietic diseases Hematology Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology Internal Medicine Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Medicine Medicine & Public Health Mice Mice, Inbred NOD Mice, SCID Multiple myeloma Multiple Myeloma - therapy Oncology, Experimental Oncolytic Virotherapy original-article Public Health Recurrence Relapse Reoviridae Reovirus Reoviruses Reverse Transcriptase Polymerase Chain Reaction Stem cell transplantation Stem Cells Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Treatment Outcome multiple myeloma murine model reovirus transplantation purging Immunopathology Animal model Hematology Rodentia Malignant hemopathy Transplantation Myeloma in vivo murine model In vivo Vertebrata Mammalia Treatment Immunoglobulinopathy Ex vivo Mouse Surgery Lymphoproliferative syndrome Graft Cancer
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