Effect of isoflurane anesthesia on hemodynamics following the administration of an angiotensin-converting enzyme inhibitor in cats

• Published in: Journal of Veterinary Medical Science Vol. 69; no. 8; pp. 869 - 871
• Main Authors: Ishikawa, Y.(Ishikawa Animal Hospital, Yokosuka, Kanagawa (Japan)), Uechi, M, Ishikawa, R, Wakao, Y, Higuchi, S
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01-08-2007; Japan Science and Technology Agency
• Subjects: ANAESTHETICS; ANESTESICOS; Anesthesia - adverse effects; Anesthesia - veterinary; ANESTHESIQUE; Anesthetics, Inhalation - adverse effects; Anesthetics, Inhalation - pharmacology; ANGIOTENSIN; Angiotensin-Converting Enzyme Inhibitors - administration & dosage; Angiotensin-Converting Enzyme Inhibitors - pharmacology; ANGIOTENSINA; ANGIOTENSINE; Animals; BLOOD CIRCULATION; BLOOD PRESSURE; Blood Pressure - drug effects; CATS; CHAT; CIRCULACION SANGUINEA; CIRCULATION SANGUINE; Enalapril - administration & dosage; Enalapril - pharmacology; ENZYME INHIBITORS; feline; GATO; hemodynamics; hypotension; Hypotension - chemically induced; Hypotension - physiopathology; INHIBIDORES DE ENZIMAS; INHIBITEUR D'ENZYME; Isoflurane - adverse effects; Isoflurane - pharmacology; PRESION SANGUINEA; PRESSION SANGUINE; Time Factors
• ISSN: 0916-7250; 1347-7439
• DOI: 10.1292/jvms.69.869

The objective of this study was to evaluate the hemodynamics of the anesthetic isoflurane in healthy cats given angiotensin-converting enzyme inhibitor (ACEI). The 7 healthy young cats and 3 old cats were received placebo or enalapril 0.5 mg/kg orally. The change in systolic arterial pressure from the baseline to 30 min postanesthesia in the ACEI group was significantly higher than in the placebo group (mean+-SD:-39+-13% vs.-17+-12%, respectively). The present study indicated that general anesthesia may induce hypotension after the administration of an ACEI.