Higher soluble P-selectin is associated with chronic venous insufficiency: The San Diego Population Study

• Published in: Thrombosis research Vol. 130; no. 5; pp. 716 - 719
• Main Authors: Bryan, Locke J, Callas, Peter W, Criqui, Michael H, Cushman, Mary
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 01-11-2012; Elsevier
• Subjects: Biological and medical sciences; Blood and lymphatic vessels; Blood coagulation; California - epidemiology; Cardiology. Vascular system; Cardiovascular system; Case-Control Studies; Chronic venous insufficiency; Cohort Studies; Cross-Sectional Studies; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Female; Hematology, Oncology and Palliative Medicine; Humans; Male; Medical sciences; Middle Aged; P-selectin; P-Selectin - metabolism; Pharmacology. Drug treatments; Risk factor; Risk Factors; Vasodilator agents. Cerebral vasodilators; Venous Insufficiency - epidemiology; Venous Insufficiency - metabolism; California; Blood coagulation; Chronic venous insufficiency; P-selectin; CVI; Risk factor; Vascular disease; P Selectin; Chronic; Cardiovascular disease; Venous incompetence; Venous disease; Varix
• ISSN: 0049-3848; 1879-2472
• DOI: 10.1016/j.thromres.2012.07.012

Abstract Introduction P-selectin is a cell adhesion molecule shown to play a role in venous thromboembolism. We evaluated whether higher P-selectin is associated with chronic venous insufficiency (CVI). Materials and Methods In a cohort of 2408 participants, the San Diego Population Study, peripheral venous disease was established by symptoms, clinical examination, and ultrasound. We measured P-selectin in a subsample of 352 CVI cases frequency matched to controls. Cases included four hierarchical groups of increasing severity of CVI. Results The association of P-selectin with CVI considering all cases was weak, with an age, race and sex-adjusted odds ratio (OR) of 1.3 (95% CI 1.0-2.2) for values in the 3rd versus 1st tertile. The OR for cases in the two most severe groups was 2.3 (95% CI 1.2-4.2). Addition of body mass index to the model reduced this OR to 1.9 (95% CI 1.0-3.6). Conclusions Higher circulating P-selectin was associated with more severe CVI, but not CVI overall. Results support that platelet and endothelial cell activation may be involved in the pathogenesis of CVI.