Chemotherapy Alters Monocyte Differentiation to Favor Generation of Cancer-Supporting M2 Macrophages in the Tumor Microenvironment

Current therapy of gynecologic malignancies consists of platinum-containing chemotherapy. Resistance to therapy is associated with increased levels of interleukin (IL)-6 and prostaglandin E2 (PGE(2)), 2 inflammatory mediators known to skew differentiation of monocytes to tumor-promoting M2 macrophag...

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Bibliographic Details
Published in:	Cancer research (Chicago, Ill.) Vol. 73; no. 8; pp. 2480 - 2492
Main Authors:	DIJKGRAAF, Eveline M, HEUSINKVELD, Moniek, TUMMERS, Bart, VOGELPOEL, LisaT. C, GOEDEMANS, Renske, JHA, Veena, NORTIER, Johan W. R, WELTERS, Marij J. P, KROEP, Judith R, VAN DER BURG, Sjoerd H
Format:	Journal Article
Language:	English
Published:	Philadelphia, PA American Association for Cancer Research 15-04-2013
Subjects:	Antigen-Presenting Cells - cytology Antigen-Presenting Cells - drug effects Antigen-Presenting Cells - immunology Antineoplastic agents Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biological and medical sciences Carboplatin - pharmacology Carboplatin - therapeutic use Cell Differentiation - drug effects Cell Line, Tumor Cell Survival - drug effects Cisplatin - pharmacology Cisplatin - therapeutic use Culture Media, Conditioned - pharmacology Dendritic Cells - cytology Dendritic Cells - drug effects Dendritic Cells - immunology Dinoprostone - biosynthesis DNA Damage Female Humans Interleukin-6 - biosynthesis Macrophages - cytology Macrophages - drug effects Macrophages - immunology Medical sciences Monocytes - cytology Monocytes - drug effects Monocytes - immunology Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasms - drug therapy Neoplasms - immunology NF-kappa B - metabolism Ovarian Neoplasms - drug therapy Ovarian Neoplasms - immunology Ovarian Neoplasms - metabolism Pharmacology. Drug treatments Receptors, Interleukin-6 - antagonists & inhibitors Receptors, Interleukin-6 - metabolism Signal Transduction - drug effects STAT Transcription Factors - metabolism Tumor Microenvironment - immunology Tumors Uterine Cervical Neoplasms - drug therapy Uterine Cervical Neoplasms - immunology Uterine Cervical Neoplasms - metabolism Chemotherapy M2 macrophage Treatment Monocyte Cell microenvironment Malignant tumor Cell differentiation Differentiation Cancer
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