The Effect of N -Acetylcysteine in the Nucleus Accumbens on Neurotransmission and Relapse to Cocaine

Background Relapse to cocaine seeking has been linked with low glutamate in the nucleus accumbens core (NAcore) causing potentiation of synaptic glutamate transmission from prefrontal cortex (PFC) afferents. Systemic N -acetylcysteine (NAC) has been shown to restore glutamate homeostasis, reduce rel...

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Bibliographic Details
Published in:	Biological psychiatry (1969) Vol. 71; no. 11; pp. 978 - 986
Main Authors:	Kupchik, Yonatan M, Moussawi, Khaled, Tang, Xing-Chun, Wang, Xiusong, Kalivas, Benjamin C, Kolokithas, Rosalia, Ogburn, Katelyn B, Kalivas, Peter W
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-06-2012 Elsevier
Subjects:	Acetylcysteine - pharmacology Addiction Animals Biological and medical sciences Cocaine Cystine - metabolism Drug-Seeking Behavior - drug effects Excitatory Postsynaptic Potentials - drug effects Free Radical Scavengers - pharmacology Glutamic Acid - metabolism Male Medical sciences mGluR2/3 mGluR5 N-acetylcysteine nucleus accumbens Nucleus Accumbens - drug effects Nucleus Accumbens - physiology Patch-Clamp Techniques Prefrontal Cortex - drug effects Prefrontal Cortex - physiology Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Rats Rats, Sprague-Dawley Receptors, Metabotropic Glutamate - drug effects Receptors, Metabotropic Glutamate - metabolism Recurrence Synaptic Transmission - drug effects mGluR2/3 nucleus accumbens Addiction cocaine mGluR5 N-acetylcysteine Thiol Relapse Central nervous system Acetylcysteine Basal ganglion Encephalon Nucleus accumbens Ester Mucolytic Cocaine Drug of abuse Neurotransmission
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