A central role for inducible heat-shock protein 70 in autoimmune vitiligo

Inducible heat‐shock protein 70 (HSP70i) is a protein regulated by stress that protects cells from undergoing apoptosis. Such proteins are marvellously well conserved throughout evolution, which has placed them in the spotlight for helping to understand the intriguing relationship between infection...

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Published in:	Experimental dermatology Vol. 22; no. 9; pp. 566 - 569
Main Authors:	Mosenson, Jeffrey A., Eby, Jonathan M., Hernandez, Claudia, Le Poole, I. Caroline
Format:	Journal Article
Language:	English
Published:	Denmark Blackwell Publishing Ltd 01-09-2013
Subjects:	autoimmune Autoimmune Diseases - etiology Autoimmune Diseases - immunology Autoimmune Diseases - therapy Cancer Vaccines - therapeutic use dendritic cell depigmentation heat-shock protein HSP70 Heat-Shock Proteins - immunology HSP70 Heat-Shock Proteins - metabolism Humans Melanocytes - immunology Melanoma - immunology mouse model Proteins - metabolism stress T cell Vitiligo - etiology Vitiligo - immunology Vitiligo - therapy stress autoimmune mouse model T cell depigmentation heat-shock protein dendritic cell
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Abstract	Inducible heat‐shock protein 70 (HSP70i) is a protein regulated by stress that protects cells from undergoing apoptosis. Such proteins are marvellously well conserved throughout evolution, which has placed them in the spotlight for helping to understand the intriguing relationship between infection and immunity. In the presence of stress proteins, dendritic cells (DCs) will sense this alarm signal and respond by recruiting immune cells of different plumage to fit the occasion. In times of stress, melanocytes will secrete antigen‐bound HSP70i to act as an alarm signal in activating DCs that comes equipped with an address of origin to drive the autoimmune response in vitiligo. Here we pose that if the autoimmune response is funnelled through HSP70i, then blocking the stress protein from activating DCs can lend new treatment opportunities for vitiligo.
AbstractList	Inducible heat‐shock protein 70 ( HSP 70i) is a protein regulated by stress that protects cells from undergoing apoptosis. Such proteins are marvellously well conserved throughout evolution, which has placed them in the spotlight for helping to understand the intriguing relationship between infection and immunity. In the presence of stress proteins, dendritic cells ( DC s) will sense this alarm signal and respond by recruiting immune cells of different plumage to fit the occasion. In times of stress, melanocytes will secrete antigen‐bound HSP 70i to act as an alarm signal in activating DC s that comes equipped with an address of origin to drive the autoimmune response in vitiligo. Here we pose that if the autoimmune response is funnelled through HSP 70i, then blocking the stress protein from activating DC s can lend new treatment opportunities for vitiligo. Inducible Heat Shock Protein 70 (HSP70i) is a protein regulated by stress that protects cells from undergoing apoptosis. Such proteins are marvelously well conserved throughout evolution, which has placed them in the spotlight for helping to understand the intriguing relationship between infection and immunity. In the presence of stress proteins, dendritic cells (DCs) will sense this alarm signal and respond by recruiting immune cells of different plumage to fit the occasion. In times of stress, melanocytes will secrete antigen bound HSP70i to act as an alarm signal in activating DCs, that comes equipped with an address of origin to drive the autoimmune response in vitiligo. Here we pose that if the autoimmune response is funneled through HSP70i, then blocking the stress protein from activating DCs can lend new treatment opportunities for vitiligo. Inducible heat-shock protein 70 (HSP70i) is a protein regulated by stress that protects cells from undergoing apoptosis. Such proteins are marvellously well conserved throughout evolution, which has placed them in the spotlight for helping to understand the intriguing relationship between infection and immunity. In the presence of stress proteins, dendritic cells (DCs) will sense this alarm signal and respond by recruiting immune cells of different plumage to fit the occasion. In times of stress, melanocytes will secrete antigen-bound HSP70i to act as an alarm signal in activating DCs that comes equipped with an address of origin to drive the autoimmune response in vitiligo. Here we pose that if the autoimmune response is funnelled through HSP70i, then blocking the stress protein from activating DCs can lend new treatment opportunities for vitiligo.
Author	Hernandez, Claudia Mosenson, Jeffrey A. Le Poole, I. Caroline Eby, Jonathan M.
Author_xml	– sequence: 1 givenname: Jeffrey A. surname: Mosenson fullname: Mosenson, Jeffrey A. organization: Departments of Pathology, Microbiology and Immunology/Cardinal Bernardin Cancer Center, Loyola University Chicago, IL, Maywood, USA – sequence: 2 givenname: Jonathan M. surname: Eby fullname: Eby, Jonathan M. organization: Departments of Pathology, Microbiology and Immunology/Cardinal Bernardin Cancer Center, Loyola University Chicago, IL, Maywood, USA – sequence: 3 givenname: Claudia surname: Hernandez fullname: Hernandez, Claudia organization: Department of Dermatology, University of Illinois at Chicago, IL, Chicago, USA – sequence: 4 givenname: I. Caroline surname: Le Poole fullname: Le Poole, I. Caroline email: ilepool@lumc.edu organization: Departments of Pathology, Microbiology and Immunology/Cardinal Bernardin Cancer Center, Loyola University Chicago, IL, Maywood, USA
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Snippet	Inducible heat‐shock protein 70 (HSP70i) is a protein regulated by stress that protects cells from undergoing apoptosis. Such proteins are marvellously well... Inducible heat-shock protein 70 (HSP70i) is a protein regulated by stress that protects cells from undergoing apoptosis. Such proteins are marvellously well... Inducible heat‐shock protein 70 ( HSP 70i) is a protein regulated by stress that protects cells from undergoing apoptosis. Such proteins are marvellously well... Inducible Heat Shock Protein 70 (HSP70i) is a protein regulated by stress that protects cells from undergoing apoptosis. Such proteins are marvelously well...
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SubjectTerms	autoimmune Autoimmune Diseases - etiology Autoimmune Diseases - immunology Autoimmune Diseases - therapy Cancer Vaccines - therapeutic use dendritic cell depigmentation heat-shock protein HSP70 Heat-Shock Proteins - immunology HSP70 Heat-Shock Proteins - metabolism Humans Melanocytes - immunology Melanoma - immunology mouse model Proteins - metabolism stress T cell Vitiligo - etiology Vitiligo - immunology Vitiligo - therapy
Title	A central role for inducible heat-shock protein 70 in autoimmune vitiligo
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