Delivery of immunostimulatory monoclonal antibodies by encapsulated hybridoma cells

Immunostimulatory monoclonal antibodies are immunoglobulins directed toward surface proteins of immune system cells that augment the immune response against cancer in a novel therapeutic fashion. Exogenous administration of the recombinant humanized immunoglobulins is being tested in clinical trials...

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Bibliographic Details
Published in:	Cancer Immunology, Immunotherapy Vol. 59; no. 11; pp. 1621 - 1631
Main Authors:	Dubrot, Juan, Portero, Aitziber, Orive, Gorka, Hernández, Rosa María, Palazón, Asis, Rouzaut, Ana, Perez-Gracia, Jose L, Hervás-Stubbs, Sandra, Pedraz, Jose Luis, Melero, Ignacio
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01-11-2010 Springer-Verlag Springer Springer Nature B.V
Subjects:	Animals Antibodies, Monoclonal - therapeutic use Antineoplastic agents Biocompatible Materials Biological and medical sciences Cancer Research Cancer therapies Capsules - administration & dosage CD137 CD40 Antigens Clinical trials Colonic Neoplasms - immunology Colonic Neoplasms - pathology Colonic Neoplasms - therapy Dendritic Cells - immunology Disease Models, Animal Encapsulated cell therapy Female Homeodomain Proteins - physiology Hybridomas - immunology Immune system Immunization Immunology Immunotherapy Laboratories Medical sciences Medicine Medicine & Public Health Mice Mice, Inbred BALB C Mice, Nude Monoclonal antibodies Oncology Original Original Article OX40 Pharmacology. Drug treatments Pharmacy Proteins Rats Survival Rate T-Lymphocytes, Cytotoxic - immunology Tumor Burden Tumor Cells, Cultured Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology Tumors OX40 Encapsulated cell therapy CD137 Performance evaluation Immunostimulation Cell therapy QX40 Hybridoma Monoclonal antibody Route of administration In vitro Costimulatory molecule Immunostimulant agent Treatment Immunotherapy Costimulatory receptor 4-1BB Technique Cell
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