Ceftriaxone choledocholithiasis

• Published in: Pediatrics (Evanston) Vol. 98; no. 1; pp. 133 - 135
• Main Authors: ROBERTSON, F. M, CROMBLEHOLME, T. M, BARLOW, S. E, VERHAVE, M, BROWN, D
• Format: Journal Article
• Language: English
• Published: Elk Grove Village, IL American Academy of Pediatrics 01-07-1996
• Subjects: Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Brain Injuries - drug therapy; Causes of; Ceftriaxone; Ceftriaxone - adverse effects; Ceftriaxone sodium; Cephalosporins - adverse effects; Child; Complications and side effects; Diagnosis, Differential; Gallstones; Gallstones - chemically induced; Gallstones - diagnosis; Gallstones - diagnostic imaging; Gallstones - surgery; Humans; Male; Medical sciences; Pediatrics; Pharmacology. Drug treatments; Ultrasonography; Human; Biliary tract; Male; Biliary tract disease; Case study; Antibiotic; Chemotherapy; Cephalosporin derivatives; Choledoch; Treatment; Lithiasis; Digestive diseases; Antibacterial agent; Child
• ISSN: 0031-4005; 1098-4275
• DOI: 10.1542/peds.98.1.133

Ceftriaxone is a broad-spectrum, third-generation cephalosporin. The formation of biliary sludge and cholelithiasis after ceftriaxone administration has been reported and is thought by many to be a benign process.1-3 Despite this, cholecystectomy has been performed in symptomatic patients who have received ceftriaxone.3,4 This complication of ceftriaxone therapy is not widely appreciated in the gastroenterology and surgical literature. We report the documented case of ceftriaxone choledocholithiasis.
CASE REPORT
A 9-year-old boy who 4 weeks before admission was treated for open head trauma was referred for evaluation of abdominal pain and cholelithiasis. The patient sustained a comminuted, depressed skull fracture of the left frontal area with underlying cerebral laceration from being kicked in the head by a horse.