Competing dopamine neurons drive oviposition choice for ethanol in Drosophila

The neural circuits that mediate behavioral choice evaluate and integrate information from the environment with internal demands and then initiate a behavioral response. Even circuits that support simple decisions remain poorly understood. In Drosophila melanogaster , oviposition on a substrate cont...

Full description

Saved in:

Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 110; no. 52; pp. 21153 - 21158
Main Authors:	Azanchi, Reza, Kaun, Karla R., Heberlein, Ulrike
Format:	Journal Article
Language:	English
Published:	Washington, DC National Academy of Sciences 24-12-2013 NATIONAL ACADEMY OF SCIENCES National Acad Sciences
Subjects:	Analysis of Variance Animal behavior Animals Biological and medical sciences Biological Sciences Brain Choice Behavior - physiology Dopamine Dopaminergic neurons Dopaminergic Neurons - metabolism Dopaminergic Neurons - physiology Drosophila Drosophila melanogaster Drosophila melanogaster - physiology Eggs Ethanol Ethanol - metabolism Female Fermentation Fruit - metabolism Fundamental and applied biological sciences. Psychology Innervation Insects Memory Mushroom Bodies - physiology Neurons Neurotransmission Oviposition Oviposition - physiology Vertebrates: nervous system and sense organs Ethanol Dopaminergic neuron
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The neural circuits that mediate behavioral choice evaluate and integrate information from the environment with internal demands and then initiate a behavioral response. Even circuits that support simple decisions remain poorly understood. In Drosophila melanogaster , oviposition on a substrate containing ethanol enhances fitness; however, little is known about the neural mechanisms mediating this important choice behavior. Here, we characterize the neural modulation of this simple choice and show that distinct subsets of dopaminergic neurons compete to either enhance or inhibit egg-laying preference for ethanol-containing food. Moreover, activity in α′β′ neurons of the mushroom body and a subset of ellipsoid body ring neurons (R2) is required for this choice. We propose a model where competing dopaminergic systems modulate oviposition preference to adjust to changes in natural oviposition substrates.
Bibliography:	http://dx.doi.org/10.1073/pnas.1320208110 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Author contributions: R.A., K.R.K., and U.H. designed research; R.A. and K.R.K. performed research; R.A., K.R.K., and U.H. analyzed data; and K.R.K. and U.H. wrote the paper. 1R.A. and K.R.K. contributed equally to this work. 2Present address: Department of Neuroscience, Brown University, Providence, RI 02912. Contributed by Ulrike Heberlein, November 6, 2013 (sent for review April 4, 2013)
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.1320208110