Abnormal Prefrontal Development in Pediatric Posttraumatic Stress Disorder: A Longitudinal Structural and Functional Magnetic Resonance Imaging Study

• Published in: Biological psychiatry : cognitive neuroscience and neuroimaging Vol. 4; no. 2; pp. 171 - 179
• Main Authors: Heyn, Sara A., Keding, Taylor J., Ross, Marisa C., Cisler, Josh M., Mumford, Jeanette A., Herringa, Ryan J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-02-2019
• Subjects: Adolescent; Brain - physiopathology; Brain Mapping; Child; Childhood trauma; Female; Functional magnetic resonance imaging; Gray Matter - growth & development; Gray Matter - physiopathology; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Neural Pathways - growth & development; Neural Pathways - physiopathology; Neurodevelopment; Pediatric; Posttraumatic stress disorder; Prefrontal Cortex - growth & development; Prefrontal Cortex - physiopathology; Stress Disorders, Post-Traumatic - etiology; Stress Disorders, Post-Traumatic - physiopathology; Structural magnetic resonance imaging; Functional magnetic resonance imaging; Neurodevelopment; Posttraumatic stress disorder; Childhood trauma; Pediatric; Structural magnetic resonance imaging
• ISSN: 2451-9022; 2451-9030
• DOI: 10.1016/j.bpsc.2018.07.013

Prior studies of pediatric posttraumatic stress disorder (PTSD) have reported cross-sectional and age-related structural and functional brain abnormalities in networks associated with cognitive, affective, and self-referential processing. However, no reported studies have comprehensively examined longitudinal gray matter development and its intrinsic functional correlates in pediatric PTSD.
Twenty-seven youths with PTSD and 21 nontraumatized typically developing (TD) youths were assessed at baseline and 1-year follow-up. At each visit, youths underwent structural magnetic resonance imaging and resting-state functional magnetic resonance imaging. Regions with volumetric abnormalities in whole-brain structural analyses were identified and used as seeds in exploratory intrinsic connectivity analyses.
Youths with PTSD exhibited sustained reductions in gray matter volume (GMV) in right ventromedial prefrontal cortex (PFC) and bilateral ventrolateral PFC. Group-by-time analyses revealed aberrant longitudinal development in dorsolateral PFC, where typically developing youths exhibited normative decreases in GMV between baseline and follow-up, and youths with PTSD showed increases in GMV. Using these regions as seeds, patients with PTSD exhibited atypical longitudinal decreases in intrinsic PFC–amygdala and PFC–hippocampus connectivity, in contrast to increases in typically developing youths. Specifically, youths with PTSD showed decreasing ventromedial PFC–amygdala connectivity as well as decreasing ventrolateral PFC–hippocampus connectivity over time. Notably, volumetric abnormalities in ventromedial PFC and ventrolateral PFC were predictive of symptom severity.
These findings represent novel longitudinal volumetric and connectivity changes in pediatric PTSD. Atypical prefrontal GMV and prefrontal-amygdala/hippocampus development may underlie persistence of PTSD in youths and could serve as future therapeutic targets.