Porous Protein Crystals as Reaction Vessels

• Published in: Chemistry : a European journal Vol. 19; no. 28; pp. 9096 - 9102
• Main Author: Ueno, Takafumi
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 08-07-2013; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Subjects: Amino acids; Amino Acids - chemistry; bioinorganic chemistry; biominerals; Channels; Chemistry; Coordination Complexes - chemical synthesis; Coordination Complexes - chemistry; Crystal lattices; Crystallization; Crystals; Metals - chemistry; Nanostructures; Porosity; Porous materials; protein assembly; protein structures; Proteins; Proteins - chemistry; Residues; Solvents; protein structures; biominerals; porous materials; protein assembly; bioinorganic chemistry
• ISSN: 0947-6539; 1521-3765
• DOI: 10.1002/chem.201300250

Porous protein crystals have the potential to provide new porous materials due to their unique chemical environments composed of amino acid residues periodically exposed at the surface of the solvent channels in the crystal lattice. This enables accumulation of external compounds in special arrangements by metal coordination interactions or by chemical modifications. This article presents a review of advances in the recently established field of porous protein crystals.
Porous protein crystals have the potential to be new porous materials due to their ability to provide unique chemical environments with amino acid residues periodically exposed on the surface of the solvent channels in the crystal lattice (see figure). This feature enables accumulation of exogenous compounds in specific arrangements facilitated by metal coordination interactions and/or chemical modifications.