Molecular Analysis of Human, Porcine, and Poultry Enterococcus faecium Isolates and Their erm(B) Genes

Fifty-nine erm(B)-positive Enterococcus faecium strains isolated from pigs, broilers, and humans were typed using multilocus sequence typing (MLST), and the coding sequence of the erm(B) gene was determined. Identical erm(B) gene sequences were detected in genetically unrelated isolates. Furthermore...

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Bibliographic Details
Published in:	Applied and Environmental Microbiology Vol. 71; no. 5; pp. 2766 - 2770
Main Authors:	De Leener, E, Martel, A, De Graef, E. M, Top, J, Butaye, P, Haesebrouck, F, Willems, R, Decostere, A
Format:	Journal Article
Language:	English
Published:	Washington, DC American Society for Microbiology 01-05-2005
Subjects:	alleles Animals antibiotic resistance Bacteria bacterial infections Bacteriology Base Sequence Biological and medical sciences broiler chickens chickens Drug Resistance, Bacterial - genetics Enterococcus faecium Enterococcus faecium - drug effects Enterococcus faecium - genetics erm(B) gene Fundamental and applied biological sciences. Psychology Gene loci genes Genes, Bacterial human diseases Humans isolation macrolide antibiotics Microbiology Molecular Sequence Data Molecular structure nucleotide sequences Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Poultry - microbiology poultry diseases Public health Public Health Microbiology strains swine Swine - microbiology swine diseases Human Typing Poultry Pig Streptococcaceae Enterococcus faecium Vertebrata Mammalia Bacteria Micrococcales Isolate Artiodactyla Ungulata
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Summary:	Fifty-nine erm(B)-positive Enterococcus faecium strains isolated from pigs, broilers, and humans were typed using multilocus sequence typing (MLST), and the coding sequence of the erm(B) gene was determined. Identical erm(B) gene sequences were detected in genetically unrelated isolates. Furthermore, genetically indistinguishable strains were found to contain different erm(B) alleles. This may suggest that horizontal exchange of the erm(B) gene between animal and human E. faecium strains or the existence of a common reservoir of erm(B) genes might be more important than direct transmission of resistant strains.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Corresponding author. Mailing address: Department of Pathology, Bacteriology and Poultry Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium. Phone: 32-9-2647376. Fax: 32-9-2647494. E-mail: ellen.deleener@UGent.be.
ISSN:	0099-2240 1098-5336
DOI:	10.1128/AEM.71.5.2766-2770.2005