Moxifloxacin versus ethambutol in the initial treatment of tuberculosis: a double-blind, randomised, controlled phase II trial

Summary Background New treatments are needed to shorten the time required to cure tuberculosis and to treat drug-resistant strains. The fluoroquinolone moxifloxacin is a promising new agent that might have additive activity to existing antituberculosis agents. We assessed the activity and safety of...

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Bibliographic Details
Published in:	The Lancet (British edition) Vol. 373; no. 9670; pp. 1183 - 1189
Main Authors:	Conde, Marcus B, MD, Efron, Anne, MSN, Loredo, Carla, RN, De Souza, Gilvan R Muzy, MD, Graça, Nadja P, MD, Cezar, Michelle C, MD, Ram, Malathi, PhD, Chaudhary, Mohammad A, PhD, Bishai, William R, Prof, Kritski, Afranio L, MD, Chaisson, Richard E, Prof
Format:	Journal Article
Language:	English
Published:	Kidlington Elsevier Ltd 04-04-2009 Elsevier Elsevier Limited
Subjects:	Adult Antitubercular Agents - adverse effects Antitubercular Agents - therapeutic use Aza Compounds - adverse effects Aza Compounds - therapeutic use Bacterial diseases Biological and medical sciences Brazil - epidemiology Double-Blind Method Drug Administration Schedule Drug Therapy, Combination Ethambutol - adverse effects Ethambutol - therapeutic use Female Fluoroquinolones General aspects Human bacterial diseases Humans Infectious diseases Internal Medicine Isoniazid - therapeutic use Kaplan-Meier Estimate Logistic Models Male Medical sciences Multivariate Analysis Mycobacterium tuberculosis Pyrazinamide - therapeutic use Quinolines - adverse effects Quinolines - therapeutic use Rifampin - therapeutic use Sputum - microbiology Time Factors Treatment Outcome Tuberculosis Tuberculosis and atypical mycobacterial infections Tuberculosis, Pulmonary - diagnosis Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - microbiology Tuberculosis, Pulmonary - mortality Brazil Brazil, Rio de Janeiro Mycobacterial infection Moxifloxacin Infection Medicine Fluoroquinolone derivatives Treatment Tuberculosis Phase II trial Bacteriosis Clinical trial Ethambutol Antituberculous agent Antibacterial agent Quinolone derivatives Comparative study
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