A single cell transcriptional roadmap of human pacemaker cell differentiation

Each heartbeat is triggered by the sinoatrial node (SAN), the primary pacemaker of the heart. Studies in animal models have revealed that pacemaker cells share a common progenitor with the (pro)epicardium, and that the pacemaker cardiomyocytes further diversify into ‘transitional’, ‘tail’, and ‘head...

Full description

Saved in:

Bibliographic Details
Published in:	eLife Vol. 11
Main Authors:	Wiesinger, Alexandra, Li, Jiuru, Fokkert, Lianne, Bakker, Priscilla, Verkerk, Arie O, Christoffels, Vincent M, Boink, Gerard JJ, Devalla, Harsha D
Format:	Journal Article
Language:	English
Published:	Cambridge eLife Science Publications, Ltd 11-10-2022 eLife Sciences Publications Ltd eLife Sciences Publications, Ltd
Subjects:	Analysis Animal models cardiac differentiation Cardiomyocytes Cell differentiation Cell therapy Developmental Biology Flow cytometry Gene expression Genetic aspects Genetic transcription Heart iPSC Ivabradine Mann-Whitney U test Molecular modelling Ontogeny pacemaker cell Pacemakers Pluripotency RNA sequencing scRNA-seq sinoatrial node Stem cell transplantation Stem cells Stem Cells and Regenerative Medicine trajectory inference Transcription factors Transforming growth factors Wnt protein
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!