Expression of functional high affinity immunoglobulin E receptors (FcεRI) on monocytes of atopic individuals

Suggestive evidence indicates that immunoglobulin E (IgE)-dependent activation of mononuclear phagocytes plays an important pathogenic role in allergic tissue inflammation. Prevailing opinion holds that low affinity IgE receptors are the relevant IgE-binding structures on monocytes/macrophages and t...

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Bibliographic Details
Published in:	The Journal of experimental medicine Vol. 179; no. 2; pp. 745 - 750
Main Authors:	MAURER, D, FIEBIGER, E, REININGER, B, WOLFF-WINISKI, B, JOUVIN, M.-H, KILGUS, O, KINET, J.-P, STINGL, G
Format:	Journal Article
Language:	English
Published:	New York, NY Rockefeller University Press 01-02-1994 The Rockefeller University Press
Subjects:	Animals Biological and medical sciences Cell Line CHO Cells Cricetinae Flow Cytometry Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Hypersensitivity, Immediate - immunology Immediate hypersensitivity. Allergy. Anaphylaxis, etc Immunobiology Monocytes - immunology Monocytes - metabolism Reaction mechanisms, antibodies, chemical mediators Receptors, IgE - biosynthesis Human Allergy Fc-Fragment Monocyte IgE Affinity Atopy Biological receptor
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Summary:	Suggestive evidence indicates that immunoglobulin E (IgE)-dependent activation of mononuclear phagocytes plays an important pathogenic role in allergic tissue inflammation. Prevailing opinion holds that low affinity IgE receptors are the relevant IgE-binding structures on monocytes/macrophages and that functional events occurring after cross-linking of membrane-bound IgE on these cells are mediated by these receptors. Here we demonstrate that peripheral blood monocytes can bind monomeric IgE via the high affinity IgE receptor (Fc epsilon RI) and that Fc epsilon RI expression on these cells is upregulated in atopic persons. Further, we demonstrate that, upon monocyte adherence to substrate, bridging of monocyte Fc epsilon RI is followed by cell activation. We propose that direct interaction of multivalent allergen with Fc epsilon RI(+)-bound IgE on mononuclear phagocytes results in cell signaling via Fc epsilon RI and that the biological consequences of this event may critically influence the outcome of allergic reactions.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0022-1007 1540-9538
DOI:	10.1084/jem.179.2.745