Dietary Intake of Micronutrients and Disease Severity in Patients with Amyotrophic Lateral Sclerosis

Vitamins and essential metals have been studied as potential risk and prognostic factors in amyotrophic lateral sclerosis (ALS). This study aimed to evaluate the prevalence of inadequate micronutrient intake in ALS patients, comparing subgroups according to the disease severity. Data were obtained f...

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Published in:	Metabolites Vol. 13; no. 6; p. 696
Main Authors:	Barros, Acsa Nara de Araújo Brito, Felipe, Maria Luisa do Nascimento, Barbosa, Isabelle Ribeiro, Leite-Lais, Lucia, Pedrosa, Lucia Fátima Campos
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 27-05-2023 MDPI
Subjects:	Amyotrophic lateral sclerosis Care and treatment Cross-sectional studies Diagnosis Dietary intake Disease Folic acid food intake Heavy metals Magnesium Malnutrition Medical prognosis Medical records Micronutrients Ostomy Outpatient care facilities Oxidative stress Pantothenic acid Potassium Pyridoxine Riboflavin Selenium Software Vitamin B Vitamin B12 Vitamin D Vitamin deficiency Vitamin E Womens health Brazil amyotrophic lateral sclerosis micronutrients food intake
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Abstract	Vitamins and essential metals have been studied as potential risk and prognostic factors in amyotrophic lateral sclerosis (ALS). This study aimed to evaluate the prevalence of inadequate micronutrient intake in ALS patients, comparing subgroups according to the disease severity. Data were obtained from the medical records of 69 individuals. Assessment of disease severity was determined by the revised ALS Functional Scale (ALSFRS-R), using the median as the cutoff. The prevalence of inadequate micronutrient intake was estimated using the Estimated Average Requirements (EAR) cut-point method. The prevalence of inadequate vitamin D, E, riboflavin, pyridoxine, folate, cobalamin, calcium, zinc, and magnesium intake was considered severe. Patients with lower ALSFRS-R scores had lower intakes of vitamin E ( < 0.001), niacin ( = 0.033), pantothenic acid ( = 0.037), pyridoxin ( = 0.008), folate ( = 0.009) and selenium ( = 0.001). Therefore, ALS patients should be monitored regarding dietary intake of micronutrients essential in neurological processes.
AbstractList	Vitamins and essential metals have been studied as potential risk and prognostic factors in amyotrophic lateral sclerosis (ALS). This study aimed to evaluate the prevalence of inadequate micronutrient intake in ALS patients, comparing subgroups according to the disease severity. Data were obtained from the medical records of 69 individuals. Assessment of disease severity was determined by the revised ALS Functional Scale (ALSFRS-R), using the median as the cutoff. The prevalence of inadequate micronutrient intake was estimated using the Estimated Average Requirements (EAR) cut-point method. The prevalence of inadequate vitamin D, E, riboflavin, pyridoxine, folate, cobalamin, calcium, zinc, and magnesium intake was considered severe. Patients with lower ALSFRS-R scores had lower intakes of vitamin E (p < 0.001), niacin (p = 0.033), pantothenic acid (p = 0.037), pyridoxin (p = 0.008), folate (p = 0.009) and selenium (p = 0.001). Therefore, ALS patients should be monitored regarding dietary intake of micronutrients essential in neurological processes. Vitamins and essential metals have been studied as potential risk and prognostic factors in amyotrophic lateral sclerosis (ALS). This study aimed to evaluate the prevalence of inadequate micronutrient intake in ALS patients, comparing subgroups according to the disease severity. Data were obtained from the medical records of 69 individuals. Assessment of disease severity was determined by the revised ALS Functional Scale (ALSFRS-R), using the median as the cutoff. The prevalence of inadequate micronutrient intake was estimated using the Estimated Average Requirements (EAR) cut-point method. The prevalence of inadequate vitamin D, E, riboflavin, pyridoxine, folate, cobalamin, calcium, zinc, and magnesium intake was considered severe. Patients with lower ALSFRS-R scores had lower intakes of vitamin E ( < 0.001), niacin ( = 0.033), pantothenic acid ( = 0.037), pyridoxin ( = 0.008), folate ( = 0.009) and selenium ( = 0.001). Therefore, ALS patients should be monitored regarding dietary intake of micronutrients essential in neurological processes. Vitamins and essential metals have been studied as potential risk and prognostic factors in amyotrophic lateral sclerosis (ALS). This study aimed to evaluate the prevalence of inadequate micronutrient intake in ALS patients, comparing subgroups according to the disease severity. Data were obtained from the medical records of 69 individuals. Assessment of disease severity was determined by the revised ALS Functional Scale (ALSFRS-R), using the median as the cutoff. The prevalence of inadequate micronutrient intake was estimated using the Estimated Average Requirements (EAR) cut-point method. The prevalence of inadequate vitamin D, E, riboflavin, pyridoxine, folate, cobalamin, calcium, zinc, and magnesium intake was considered severe. Patients with lower ALSFRS-R scores had lower intakes of vitamin E ( p < 0.001), niacin ( p = 0.033), pantothenic acid ( p = 0.037), pyridoxin ( p = 0.008), folate ( p = 0.009) and selenium ( p = 0.001). Therefore, ALS patients should be monitored regarding dietary intake of micronutrients essential in neurological processes.
Audience	Academic
Author	Felipe, Maria Luisa do Nascimento Leite-Lais, Lucia Pedrosa, Lucia Fátima Campos Barbosa, Isabelle Ribeiro Barros, Acsa Nara de Araújo Brito
AuthorAffiliation	3 Faculty of Health Sciences of Trairi (FACISA), Federal University of Rio Grande do Norte, Santa Cruz 59200-000, RN, Brazil; isabelleribeiro68@gmail.com 2 Postgraduate Program in Nutrition, Health Sciences Center, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil; maria.luisa.felipe.111@ufrn.edu.br 4 Department of Nutrition, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil; lucia.leite@ufrn.br 1 Postgraduate Program in Health Sciences, Health Sciences Center, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil; acsa.barros@ufrn.br
AuthorAffiliation_xml	– name: 3 Faculty of Health Sciences of Trairi (FACISA), Federal University of Rio Grande do Norte, Santa Cruz 59200-000, RN, Brazil; isabelleribeiro68@gmail.com – name: 1 Postgraduate Program in Health Sciences, Health Sciences Center, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil; acsa.barros@ufrn.br – name: 2 Postgraduate Program in Nutrition, Health Sciences Center, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil; maria.luisa.felipe.111@ufrn.edu.br – name: 4 Department of Nutrition, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil; lucia.leite@ufrn.br
Author_xml	– sequence: 1 givenname: Acsa Nara de Araújo Brito surname: Barros fullname: Barros, Acsa Nara de Araújo Brito organization: Postgraduate Program in Health Sciences, Health Sciences Center, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil – sequence: 2 givenname: Maria Luisa do Nascimento orcidid: 0009-0001-7118-8747 surname: Felipe fullname: Felipe, Maria Luisa do Nascimento organization: Postgraduate Program in Nutrition, Health Sciences Center, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil – sequence: 3 givenname: Isabelle Ribeiro surname: Barbosa fullname: Barbosa, Isabelle Ribeiro organization: Faculty of Health Sciences of Trairi (FACISA), Federal University of Rio Grande do Norte, Santa Cruz 59200-000, RN, Brazil – sequence: 4 givenname: Lucia surname: Leite-Lais fullname: Leite-Lais, Lucia organization: Department of Nutrition, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil – sequence: 5 givenname: Lucia Fátima Campos orcidid: 0000-0002-5436-5115 surname: Pedrosa fullname: Pedrosa, Lucia Fátima Campos organization: Faculty of Health Sciences of Trairi (FACISA), Federal University of Rio Grande do Norte, Santa Cruz 59200-000, RN, Brazil
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CitedBy_id	crossref_primary_10_3390_cells13110967 crossref_primary_10_17116_jnevro202412404113 crossref_primary_10_3390_nu15173706 crossref_primary_10_1515_biol_2022_0842
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SubjectTerms	Amyotrophic lateral sclerosis Care and treatment Cross-sectional studies Diagnosis Dietary intake Disease Folic acid food intake Heavy metals Magnesium Malnutrition Medical prognosis Medical records Micronutrients Ostomy Outpatient care facilities Oxidative stress Pantothenic acid Potassium Pyridoxine Riboflavin Selenium Software Vitamin B Vitamin B12 Vitamin D Vitamin deficiency Vitamin E Womens health
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Title	Dietary Intake of Micronutrients and Disease Severity in Patients with Amyotrophic Lateral Sclerosis
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