COVID-19: Current Trends in Invitro Diagnostics

• Published in: Indian journal of clinical biochemistry Vol. 35; no. 3; pp. 285 - 289
• Main Authors: Arun Krishnan, R., Elizabeth Thomas, Rhema, Sukumaran, Ajaikumar, Paul, Jofy K., Vasudevan, D. M.
• Format: Journal Article
• Language: English
• Published: New Delhi Springer India 01-07-2020; Springer; Springer Nature B.V
• Subjects: Antiviral agents; Biochemistry; Biomedical and Life Sciences; Chemistry/Food Science; Coronaviridae; Coronaviruses; COVID-19; Disease transmission; Health aspects; Life Sciences; Microbiology; Nucleic acids; Pandemics; Pathology; Polymerase chain reaction; Review; Review Article; Severe acute respiratory syndrome coronavirus 2; Vaccines; Viral diseases; Virus diseases; Reverse transcriptase PCR; SARS-CoV-2; Loop mediated isothermal amplification; CLIA; Lateral flow immunoassay; ELISA
• ISSN: 0970-1915; 0974-0422
• DOI: 10.1007/s12291-020-00906-5

The novel coronavirus SARS-CoV-2 is the seventh known species of coronavirus, infectious to human beings. The pandemic COVID-19 spread all over the world with an unprecedented spreading rate after its first appearance in Wuhan, China. As a novel viral disease there in no antiviral treatment or vaccine for the COVID-19. At present, the early detection and the quarantine of infected patients are the ways to stop the spreading of the disease. This review will discuss about the current invitro diagnostic methods used worldwide for the early and accurate diagnosis of COVID-19. Currently the nucleic acid based polymerase chain reaction is used as the reliable diagnostic platform and antigen/antibody detection immunoassays are playing the role of screening tests for early detection and prognosis in COVID-19 treatment.