Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy

In HIV-1-infected individuals on currently recommended antiretroviral therapy (ART), viremia is reduced to <50 copies of HIV-1 RNA per milliliter, but low-level residual viremia appears to persist over the lifetimes of most infected individuals. There is controversy over whether the residual vire...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 106; no. 23; pp. 9403 - 9408
Main Authors:	Dinoso, J.B, Kim, S.Y, Wiegand, A.M, Palmer, S.E, Gange, S.J, Cranmer, L, O'Shea, A, Callender, M, Spivak, A, Brennan, T, Kearney, M.F, Proschan, M.A, Mican, J.M, Rehm, C.A, Coffin, J.M, Mellors, J.W, Siliciano, R.F, Maldarelli, F
Format:	Journal Article
Language:	English
Published:	United States National Academy of Sciences 09-06-2009 National Acad Sciences
Subjects:	Adult Anti-HIV Agents Antiretroviral drugs Antiretroviral Therapy, Highly Active Antiretrovirals Antiviral agents Antivirals Arts Biological Sciences Drug resistance Drug therapy Drugs Efavirenz highly active antiretroviral therapy HIV HIV 1 HIV Infections - drug therapy HIV Infections - virology HIV-1 - physiology Human immunodeficiency virus Human immunodeficiency virus 1 Humans Infection Infections Lopinavir Pharmacology Prospective Studies Replication Ribonucleic acid Ritonavir RNA T lymphocytes Viremia Viremia - drug therapy Virus Replication Viruses
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