Studying auditory verbal hallucinations using the RDoC framework

• Published in: Psychophysiology Vol. 53; no. 3; pp. 298 - 304
• Main Author: Ford, Judith M.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01-03-2016
• Subjects: Acoustic Stimulation; Agency; Auditory Cortex - physiopathology; Auditory verbal hallucinations; Brain - physiopathology; Cortical Synchronization; EEG; Electroencephalography; ERP; Evoked Potentials, Auditory; Frontal Lobe - physiopathology; Hallucinations; Hallucinations - physiopathology; Humans; Mental disorders; Neural Pathways - physiopathology; Neuropsychology; Primates; Psychomotor Performance; Psychopathology; Psychopathology - methods; RDoC; Research Design; Schizophrenia - physiopathology; Schizophrenic Psychology; Self Efficacy; Speech; Speech Perception; RDoC; ERP; Agency; N1; EEG; Auditory verbal hallucinations
• ISSN: 0048-5772; 1469-8986; 1540-5958
• DOI: 10.1111/psyp.12457

In this paper, I explain why I adopted a Research Domain Criteria (RDoC) approach to study the neurobiology of auditory verbal hallucinations (AVH), or voices. I explain that the RDoC construct of “agency” fits well with AVH phenomenology. To the extent that voices sound nonself, voice hearers lack a sense of agency over the voices. Using a vocalization paradigm like those used with nonhuman primates to study mechanisms subserving the sense of agency, we find that the auditory N1 ERP is suppressed during vocalization, that EEG synchrony preceding speech onset is related to N1 suppression, and that both are reduced in patients with schizophrenia. Reduced cortical suppression is also seen across multiple psychotic disorders and in clinically high‐risk youth, but it is not related to AVH. The motor activity preceding talking and connectivity between frontal and temporal lobes during talking have both proved sensitive to AVH, suggesting neural activity and connectivity associated with intentions to act may be a better way to study agency and predictions based on agency.